Evidence that the anti-spasmogenic effect of the [beta]-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cyclic AMP-dependent protein kinase

1. The spasmolytic and anti-spasmogenic activity of beta-adrenoceptor agonists on airways smooth muscle is thought to involve activation of the cyclic AMP/cyclic AMP-dependent protein kinase (PKA) cascade. Here we have tested the hypothesis that PKA mediates the anti-spasmogenic activity of isoprena...

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Veröffentlicht in:	British journal of pharmacology 2001-08, Vol.133 (8), p.1201
Hauptverfasser:	Spicuzza, Lucia, Belvisi, Maria G, Birrell, Mark A, Barnes, Peter J, Hele, David J, Giembycz, Mark A
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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