Gabexate mesilate, a synthetic protease inhibitor, attenuates carbon tetrachloride-induced liver injury in rats

Gabexate mesilate, a synthetic protease inhibitor, is used to treat acute pancreatitis and disseminated intravascular coagulation because it inhibits various serine proteases; however, whether gabexate mesilate prevents acute liver failure has not yet been studied. The aim of the present study was t...

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Veröffentlicht in:	Journal of gastroenterology 2005-03, Vol.40 (3), p.260-265
Hauptverfasser:	Mikami, Ken-ichiro, Goto, Takashi, Miura, Kouichi, Ohshima, Shigetoshi, Yoneyama, Kazuo, Lin, Jiun-Guey, Watanabe, Daisuke, Segawa, Daisuke, Kataoka, Ei, Shibuya, Tomomi, Watanabe, Sumio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbon Tetrachloride - administration & dosage Carbon Tetrachloride - toxicity Chemical and Drug Induced Liver Injury Disease Models, Animal Disease Progression Enzyme-Linked Immunosorbent Assay Gabexate - therapeutic use Interleukin-1 - blood Lethal Dose 50 Liver - drug effects Liver - pathology Liver Diseases - blood Liver Diseases - drug therapy Male Rats Rats, Sprague-Dawley Serine Proteinase Inhibitors - therapeutic use Transaminases - blood Tumor Necrosis Factor-alpha - metabolism
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