Functional analysis of recombinant pancreatic secretory trypsin inhibitor protein with amino-acid substitution

We hypothesized that mutation of the pancreatic secretory trypsin inhibitor ( PSTI) gene may promote a predisposition to pancreatitis, possibly by reducing the inhibition of trypsin activity. Based on this hypothesis, we performed a biochemical analysis of recombinant PSTI protein. The trypsin inhib...

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Veröffentlicht in:	Journal of gastroenterology 2002-11, Vol.37 (11), p.928-934
Hauptverfasser:	Kuwata, Kinuko, Hirota, Masahiko, Shimizu, Hiroyuki, Nakae, Masanori, Nishihara, Shoji, Takimoto, Akio, Mitsushima, Kenji, Kikuchi, Norihisa, Endo, Kazuaki, Inoue, Masayasu, Ogawa, Michio
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution - genetics Animals Carrier Proteins Cattle Disease Models, Animal Gene Expression - genetics Genetic Predisposition to Disease Growth Substances - genetics Humans In Vitro Techniques Intercellular Signaling Peptides and Proteins - genetics Mutagenesis, Site-Directed - genetics Mutation - genetics Pancreatitis - genetics Recombinant Proteins - genetics Time Factors Trypsin Inhibitor, Kazal Pancreatic - genetics
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