Evaluation and Management of Penicillin Allergy: A Review

IMPORTANCE: β-Lactam antibiotics are among the safest and most effective antibiotics. Many patients report allergies to these drugs that limit their use, resulting in the use of broad-spectrum antibiotics that increase the risk for antimicrobial resistance and adverse events. OBSERVATIONS: Approxima...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 2019-01, Vol.321 (2), p.188-199
Hauptverfasser:	Shenoy, Erica S, Macy, Eric, Rowe, Theresa, Blumenthal, Kimberly G
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergies Amides Amoxicillin Amoxicillin - adverse effects Amoxicillin - therapeutic use Anaphylaxis Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - immunology Anti-Bacterial Agents - therapeutic use Antibiotic resistance Antibiotics Antiinfectives and antibacterials Antimicrobial agents Antimicrobial resistance beta-Lactams - adverse effects beta-Lactams - immunology Cephalosporins Clinical significance Cross-reactivity Desensitization, Immunologic Drug Hypersensitivity - diagnosis Drug Hypersensitivity - immunology Drug Hypersensitivity - therapy Drug resistance Drugs Evaluation Female Gastrointestinal symptoms Genetics Humans Hypersensitivity Identification methods Immunoglobulin E Immunologic Tests Lymphocytes T Methicillin Patient Acuity Patients Penicillin Penicillins - adverse effects Penicillins - immunology Penicillins - therapeutic use Pregnancy Pruritus Risk Skin tests Urticaria Vancomycin β-Lactam antibiotics
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