Successful Pregnancy and Delivery in a Patient with Chronic Myelogenous Leukemia (CML), and Management of CML with Leukapheresis during Pregnancy: a Case Report and Review of the Literature
Although infrequently seen, the management of cancer during pregnancy can be difficult for patients, their families and physicians. The concomitant occurrence of pregnancy and chronic myelogenous leukemia is uncommon. We describe the successful management of a 26-year-old woman in the first trimeste...
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| Veröffentlicht in: | Japanese journal of clinical oncology 2004-04, Vol.34 (4), p.215-217 |
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| container_title | Japanese journal of clinical oncology |
| container_volume | 34 |
| creator | Ali, Ridvan Özkalemkas, Fahir Özkocaman, Vildan Özçelik, Tülay Ozan, Ülkü Kimya, Yalçin Tunali, Ahmet |
| description | Although infrequently seen, the management of cancer during pregnancy can be difficult for patients, their families and physicians. The concomitant occurrence of pregnancy and chronic myelogenous leukemia is uncommon. We describe the successful management of a 26-year-old woman in the first trimester of her pregnancy with chronic myelogenous leukemia (CML) in chronic phase by using only leukapheresis. She was treated with leukapheresis until her delivery at 36 weeks of gestation. The procedure was without significant adverse effects on the patient or fetus. We applied a total of 15 leukapheresis treatments throughout the pregnancy. The patient gave birth vaginally to a healthy 2800 g boy at 36 weeks of gestation. We conclude that leukapheresis may provide an alternative treatment to chemotherapy, α-interferon or imatinib in pregnant patients with CML, particularly with concern over their potential teratogenic and other adverse effects. |
| doi_str_mv | 10.1093/jjco/hyh038 |
| format | Article |
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The concomitant occurrence of pregnancy and chronic myelogenous leukemia is uncommon. We describe the successful management of a 26-year-old woman in the first trimester of her pregnancy with chronic myelogenous leukemia (CML) in chronic phase by using only leukapheresis. She was treated with leukapheresis until her delivery at 36 weeks of gestation. The procedure was without significant adverse effects on the patient or fetus. We applied a total of 15 leukapheresis treatments throughout the pregnancy. The patient gave birth vaginally to a healthy 2800 g boy at 36 weeks of gestation. We conclude that leukapheresis may provide an alternative treatment to chemotherapy, α-interferon or imatinib in pregnant patients with CML, particularly with concern over their potential teratogenic and other adverse effects.</description><identifier>ISSN: 0368-2811</identifier><identifier>ISSN: 1465-3621</identifier><identifier>EISSN: 1465-3621</identifier><identifier>DOI: 10.1093/jjco/hyh038</identifier><identifier>PMID: 15121759</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adult ; Delivery, Obstetric ; Female ; Humans ; Key words: chronic myelogenous leukemia – pregnancy – leukapheresis ; Leukapheresis - methods ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - therapy ; Pregnancy ; Pregnancy Complications, Neoplastic - therapy</subject><ispartof>Japanese journal of clinical oncology, 2004-04, Vol.34 (4), p.215-217</ispartof><rights>Copyright Oxford University Press(England) Apr 01, 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3268-b14141fea7447dd124051936802e193b431e4eaf55a89a77bd09b4b313b26433</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15121759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ali, Ridvan</creatorcontrib><creatorcontrib>Özkalemkas, Fahir</creatorcontrib><creatorcontrib>Özkocaman, Vildan</creatorcontrib><creatorcontrib>Özçelik, Tülay</creatorcontrib><creatorcontrib>Ozan, Ülkü</creatorcontrib><creatorcontrib>Kimya, Yalçin</creatorcontrib><creatorcontrib>Tunali, Ahmet</creatorcontrib><title>Successful Pregnancy and Delivery in a Patient with Chronic Myelogenous Leukemia (CML), and Management of CML with Leukapheresis during Pregnancy: a Case Report and Review of the Literature</title><title>Japanese journal of clinical oncology</title><addtitle>JJCO</addtitle><description>Although infrequently seen, the management of cancer during pregnancy can be difficult for patients, their families and physicians. 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We conclude that leukapheresis may provide an alternative treatment to chemotherapy, α-interferon or imatinib in pregnant patients with CML, particularly with concern over their potential teratogenic and other adverse effects.</description><subject>Adult</subject><subject>Delivery, Obstetric</subject><subject>Female</subject><subject>Humans</subject><subject>Key words: chronic myelogenous leukemia – pregnancy – leukapheresis</subject><subject>Leukapheresis - methods</subject><subject>Leukemia, Myelogenous, Chronic, BCR-ABL Positive - therapy</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Neoplastic - therapy</subject><issn>0368-2811</issn><issn>1465-3621</issn><issn>1465-3621</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUFv1DAQhS0EokvhxB1ZnEAQasdOnHBDgdJWWVFtK4S4WE4y2Xi7ay920pIf1_-G06yofBjJ88170nsIvabkEyU5O9lsanvSjR1h2RO0oDxNIpbG9ClaEJZmUZxReoReeL8hhCQZF8_REU1oTEWSL9D91VDX4H07bPGlg7VRph6xMg3-Clt9C27E2mCFL1WvwfT4TvcdLjpnja7xcoStXYOxg8clDDew0wq_K5bl-48PEktl1Bp2051tcfifzydU7Ttw4LXHzeC0WT-afw5uhfKAV7C3rn8QWsGthrtJpO8Al7oHp_rBwUv0rFVbD68O8xhdn367Ls6i8sf38-JLGdUsDhFUlIfXghKci6ahMScJzUM4JIYwK84ocFBtkqgsV0JUDckrXjHKqjjljB2jt7Ps3tk_A_hebuzgTHCUIUZKSUg1QB9mqHbWewet3Du9U26UlMipKDkVJeeiAv3mIDlUO2ge2UMzAYhmQPse_v7fK3cjU8FEIs9-_ZY_r-KLZboSMmX_ACj4n7A</recordid><startdate>20040401</startdate><enddate>20040401</enddate><creator>Ali, Ridvan</creator><creator>Özkalemkas, Fahir</creator><creator>Özkocaman, Vildan</creator><creator>Özçelik, Tülay</creator><creator>Ozan, Ülkü</creator><creator>Kimya, Yalçin</creator><creator>Tunali, Ahmet</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope></search><sort><creationdate>20040401</creationdate><title>Successful Pregnancy and Delivery in a Patient with Chronic Myelogenous Leukemia (CML), and Management of CML with Leukapheresis during Pregnancy: a Case Report and Review of the Literature</title><author>Ali, Ridvan ; 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| fulltext | fulltext |
| identifier | ISSN: 0368-2811 |
| ispartof | Japanese journal of clinical oncology, 2004-04, Vol.34 (4), p.215-217 |
| issn | 0368-2811 1465-3621 1465-3621 |
| language | eng |
| recordid | cdi_proquest_journals_217110847 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Freely Accessible Japanese Titles; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Delivery, Obstetric Female Humans Key words: chronic myelogenous leukemia – pregnancy – leukapheresis Leukapheresis - methods Leukemia, Myelogenous, Chronic, BCR-ABL Positive - therapy Pregnancy Pregnancy Complications, Neoplastic - therapy |
| title | Successful Pregnancy and Delivery in a Patient with Chronic Myelogenous Leukemia (CML), and Management of CML with Leukapheresis during Pregnancy: a Case Report and Review of the Literature |
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