Efficacy and Feasibility of Cisplatin-Based Concurrent Chemoradiotherapy for Nasopharyngeal Carcinoma
Objective: To investigate the efficacy and feasibility of a cisplatin-based concurrent chemoradiotherapy (CRT) protocol based on Intergroup Study 0099 for nasopharyngeal carcinoma (NPC). Methods: Sixteen patients with stage II–IVB NPC were treated with a protocol of cisplatin-based concurrent CRT an...
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| Veröffentlicht in: | Japanese journal of clinical oncology 2006-10, Vol.36 (10), p.620-625 |
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| creator | Demizu, Yusuke Sasaki, Ryohei Soejima, Toshinori Maruta, Tsutomu Okamoto, Yoshiaki Yamada, Kazunari Yoden, Eisaku Ejima, Yasuo Ota, Yosuke Ishida, Haruhiko Nibu, Kenichi Sugimura, Kazuro |
| description | Objective: To investigate the efficacy and feasibility of a cisplatin-based concurrent chemoradiotherapy (CRT) protocol based on Intergroup Study 0099 for nasopharyngeal carcinoma (NPC). Methods: Sixteen patients with stage II–IVB NPC were treated with a protocol of cisplatin-based concurrent CRT and adjuvant chemotherapy from 1998 to 2002. Three courses of cisplatin (80 mg/m2) were scheduled during 70 Gy of radiotherapy (RT), and two agents of adjuvant chemotherapy (FP regimen: cisplatin 80 mg/m2 and 5-fluorouracil 800 mg/m2/day by 4-day continuous infusion) were challenged. Overall survival (OS) and relapse-free survival (RFS) rates were calculated by the Kaplan–Meier method. Results: Median follow-up duration was 45 months. Both 3-year OS and RFS rates were 81%. Proportions of patients who tolerated each scheduled treatment were 94% for RT, 63% for concurrent chemotherapy and 38% for adjuvant chemotherapy. Conclusions: Our protocol of the cisplatin-based concurrent CRT followed by adjuvant chemotherapy consisting of FP regimen was effective for Japanese patients with NPC. However, the doses and numbers of cycle of chemotherapy need to be modified because of the low compliance rate. Larger numbers of data accumulation and/or multi-institutional trials may be warranted to confirm the efficacy of this protocol. |
| doi_str_mv | 10.1093/jjco/hyl083 |
| format | Article |
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Methods: Sixteen patients with stage II–IVB NPC were treated with a protocol of cisplatin-based concurrent CRT and adjuvant chemotherapy from 1998 to 2002. Three courses of cisplatin (80 mg/m2) were scheduled during 70 Gy of radiotherapy (RT), and two agents of adjuvant chemotherapy (FP regimen: cisplatin 80 mg/m2 and 5-fluorouracil 800 mg/m2/day by 4-day continuous infusion) were challenged. Overall survival (OS) and relapse-free survival (RFS) rates were calculated by the Kaplan–Meier method. Results: Median follow-up duration was 45 months. Both 3-year OS and RFS rates were 81%. Proportions of patients who tolerated each scheduled treatment were 94% for RT, 63% for concurrent chemotherapy and 38% for adjuvant chemotherapy. Conclusions: Our protocol of the cisplatin-based concurrent CRT followed by adjuvant chemotherapy consisting of FP regimen was effective for Japanese patients with NPC. However, the doses and numbers of cycle of chemotherapy need to be modified because of the low compliance rate. Larger numbers of data accumulation and/or multi-institutional trials may be warranted to confirm the efficacy of this protocol.</description><identifier>ISSN: 0368-2811</identifier><identifier>EISSN: 1465-3621</identifier><identifier>DOI: 10.1093/jjco/hyl083</identifier><identifier>PMID: 16905756</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adolescent ; Adult ; Aged ; Anemia - chemically induced ; Antineoplastic Combined Chemotherapy Protocols - administration & dosage ; Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Chemotherapy, Adjuvant ; cisplatin ; Cisplatin - administration & dosage ; Cisplatin - adverse effects ; concurrent chemoradiotherapy ; Deglutition Disorders ; Drug Administration Schedule ; Feasibility Studies ; Female ; Fluorouracil - administration & dosage ; Fluorouracil - adverse effects ; Humans ; Intergroup Study 0099 ; Male ; Middle Aged ; nasopharyngeal carcinoma ; Nasopharyngeal Neoplasms - drug therapy ; Nasopharyngeal Neoplasms - pathology ; Nasopharyngeal Neoplasms - radiotherapy ; Neoadjuvant Therapy ; Neoplasm Staging ; Neutropenia - chemically induced ; radiotherapy ; Radiotherapy Dosage ; Survival Rate</subject><ispartof>Japanese journal of clinical oncology, 2006-10, Vol.36 (10), p.620-625</ispartof><rights>Copyright Oxford University Press(England) Oct 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-4d18fbb7756bc9992d16343d41663a5f2f826f99f9102c35246199b3df5324293</citedby><cites>FETCH-LOGICAL-c479t-4d18fbb7756bc9992d16343d41663a5f2f826f99f9102c35246199b3df5324293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16905756$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Demizu, Yusuke</creatorcontrib><creatorcontrib>Sasaki, Ryohei</creatorcontrib><creatorcontrib>Soejima, Toshinori</creatorcontrib><creatorcontrib>Maruta, Tsutomu</creatorcontrib><creatorcontrib>Okamoto, Yoshiaki</creatorcontrib><creatorcontrib>Yamada, Kazunari</creatorcontrib><creatorcontrib>Yoden, Eisaku</creatorcontrib><creatorcontrib>Ejima, Yasuo</creatorcontrib><creatorcontrib>Ota, Yosuke</creatorcontrib><creatorcontrib>Ishida, Haruhiko</creatorcontrib><creatorcontrib>Nibu, Kenichi</creatorcontrib><creatorcontrib>Sugimura, Kazuro</creatorcontrib><title>Efficacy and Feasibility of Cisplatin-Based Concurrent Chemoradiotherapy for Nasopharyngeal Carcinoma</title><title>Japanese journal of clinical oncology</title><addtitle>JJCO</addtitle><description>Objective: To investigate the efficacy and feasibility of a cisplatin-based concurrent chemoradiotherapy (CRT) protocol based on Intergroup Study 0099 for nasopharyngeal carcinoma (NPC). Methods: Sixteen patients with stage II–IVB NPC were treated with a protocol of cisplatin-based concurrent CRT and adjuvant chemotherapy from 1998 to 2002. Three courses of cisplatin (80 mg/m2) were scheduled during 70 Gy of radiotherapy (RT), and two agents of adjuvant chemotherapy (FP regimen: cisplatin 80 mg/m2 and 5-fluorouracil 800 mg/m2/day by 4-day continuous infusion) were challenged. Overall survival (OS) and relapse-free survival (RFS) rates were calculated by the Kaplan–Meier method. Results: Median follow-up duration was 45 months. Both 3-year OS and RFS rates were 81%. Proportions of patients who tolerated each scheduled treatment were 94% for RT, 63% for concurrent chemotherapy and 38% for adjuvant chemotherapy. Conclusions: Our protocol of the cisplatin-based concurrent CRT followed by adjuvant chemotherapy consisting of FP regimen was effective for Japanese patients with NPC. However, the doses and numbers of cycle of chemotherapy need to be modified because of the low compliance rate. Larger numbers of data accumulation and/or multi-institutional trials may be warranted to confirm the efficacy of this protocol.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anemia - chemically induced</subject><subject>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</subject><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Chemotherapy, Adjuvant</subject><subject>cisplatin</subject><subject>Cisplatin - administration & dosage</subject><subject>Cisplatin - adverse effects</subject><subject>concurrent chemoradiotherapy</subject><subject>Deglutition Disorders</subject><subject>Drug Administration Schedule</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Fluorouracil - administration & dosage</subject><subject>Fluorouracil - adverse effects</subject><subject>Humans</subject><subject>Intergroup Study 0099</subject><subject>Male</subject><subject>Middle Aged</subject><subject>nasopharyngeal carcinoma</subject><subject>Nasopharyngeal Neoplasms - drug therapy</subject><subject>Nasopharyngeal Neoplasms - pathology</subject><subject>Nasopharyngeal Neoplasms - radiotherapy</subject><subject>Neoadjuvant Therapy</subject><subject>Neoplasm Staging</subject><subject>Neutropenia - chemically induced</subject><subject>radiotherapy</subject><subject>Radiotherapy Dosage</subject><subject>Survival Rate</subject><issn>0368-2811</issn><issn>1465-3621</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLxDAUhYMoOj5W7iW4lTp5t1lqGR8gI8II4iakaeJk7DQ16YD991Zm0NVd3I9zDh8A5xhdYyTpdLUyYbocGlTQPTDBTPCMCoL3wQRRUWSkwPgIHKe0QgjxguWH4AgLiXjOxQTYmXPeaDNA3dbwzurkK9_4foDBwdKnrtG9b7NbnWwNy9CaTYy27WG5tOsQde1Dv7RRdwN0IcK5TqFb6ji0H1Y3sNTR-Das9Sk4cLpJ9mx3T8Dr3WxRPmRPz_eP5c1TZlgu-4zVuHBVlY_LKiOlJDUWlNGaYSGo5o64gggnpZMYEUM5YQJLWdHacUoYkfQEXG5zuxi-Njb1ahU2sR0rFcE5RmNYPkJXW8jEkFK0TnXRr8fRCiP1a1T9GlVboyN9sYvcVGtb_7M7hSOQbQGfevv999fxU4mc5lw9vL0rzF8Em78s1IL-AJfmgfY</recordid><startdate>20061001</startdate><enddate>20061001</enddate><creator>Demizu, Yusuke</creator><creator>Sasaki, Ryohei</creator><creator>Soejima, Toshinori</creator><creator>Maruta, Tsutomu</creator><creator>Okamoto, Yoshiaki</creator><creator>Yamada, Kazunari</creator><creator>Yoden, Eisaku</creator><creator>Ejima, Yasuo</creator><creator>Ota, Yosuke</creator><creator>Ishida, Haruhiko</creator><creator>Nibu, Kenichi</creator><creator>Sugimura, Kazuro</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope></search><sort><creationdate>20061001</creationdate><title>Efficacy and Feasibility of Cisplatin-Based Concurrent Chemoradiotherapy for Nasopharyngeal Carcinoma</title><author>Demizu, Yusuke ; Sasaki, Ryohei ; Soejima, Toshinori ; Maruta, Tsutomu ; Okamoto, Yoshiaki ; Yamada, Kazunari ; Yoden, Eisaku ; Ejima, Yasuo ; Ota, Yosuke ; Ishida, Haruhiko ; Nibu, Kenichi ; Sugimura, Kazuro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-4d18fbb7756bc9992d16343d41663a5f2f826f99f9102c35246199b3df5324293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anemia - chemically induced</topic><topic>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</topic><topic>Antineoplastic Combined Chemotherapy Protocols - adverse effects</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Chemotherapy, Adjuvant</topic><topic>cisplatin</topic><topic>Cisplatin - administration & dosage</topic><topic>Cisplatin - adverse effects</topic><topic>concurrent chemoradiotherapy</topic><topic>Deglutition Disorders</topic><topic>Drug Administration Schedule</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Fluorouracil - administration & dosage</topic><topic>Fluorouracil - adverse effects</topic><topic>Humans</topic><topic>Intergroup Study 0099</topic><topic>Male</topic><topic>Middle Aged</topic><topic>nasopharyngeal carcinoma</topic><topic>Nasopharyngeal Neoplasms - drug therapy</topic><topic>Nasopharyngeal Neoplasms - pathology</topic><topic>Nasopharyngeal Neoplasms - radiotherapy</topic><topic>Neoadjuvant Therapy</topic><topic>Neoplasm Staging</topic><topic>Neutropenia - chemically induced</topic><topic>radiotherapy</topic><topic>Radiotherapy Dosage</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Demizu, Yusuke</creatorcontrib><creatorcontrib>Sasaki, Ryohei</creatorcontrib><creatorcontrib>Soejima, Toshinori</creatorcontrib><creatorcontrib>Maruta, Tsutomu</creatorcontrib><creatorcontrib>Okamoto, Yoshiaki</creatorcontrib><creatorcontrib>Yamada, Kazunari</creatorcontrib><creatorcontrib>Yoden, Eisaku</creatorcontrib><creatorcontrib>Ejima, Yasuo</creatorcontrib><creatorcontrib>Ota, Yosuke</creatorcontrib><creatorcontrib>Ishida, Haruhiko</creatorcontrib><creatorcontrib>Nibu, Kenichi</creatorcontrib><creatorcontrib>Sugimura, Kazuro</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Japanese journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Demizu, Yusuke</au><au>Sasaki, Ryohei</au><au>Soejima, Toshinori</au><au>Maruta, Tsutomu</au><au>Okamoto, Yoshiaki</au><au>Yamada, Kazunari</au><au>Yoden, Eisaku</au><au>Ejima, Yasuo</au><au>Ota, Yosuke</au><au>Ishida, Haruhiko</au><au>Nibu, Kenichi</au><au>Sugimura, Kazuro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy and Feasibility of Cisplatin-Based Concurrent Chemoradiotherapy for Nasopharyngeal Carcinoma</atitle><jtitle>Japanese journal of clinical oncology</jtitle><addtitle>JJCO</addtitle><date>2006-10-01</date><risdate>2006</risdate><volume>36</volume><issue>10</issue><spage>620</spage><epage>625</epage><pages>620-625</pages><issn>0368-2811</issn><eissn>1465-3621</eissn><abstract>Objective: To investigate the efficacy and feasibility of a cisplatin-based concurrent chemoradiotherapy (CRT) protocol based on Intergroup Study 0099 for nasopharyngeal carcinoma (NPC). Methods: Sixteen patients with stage II–IVB NPC were treated with a protocol of cisplatin-based concurrent CRT and adjuvant chemotherapy from 1998 to 2002. Three courses of cisplatin (80 mg/m2) were scheduled during 70 Gy of radiotherapy (RT), and two agents of adjuvant chemotherapy (FP regimen: cisplatin 80 mg/m2 and 5-fluorouracil 800 mg/m2/day by 4-day continuous infusion) were challenged. Overall survival (OS) and relapse-free survival (RFS) rates were calculated by the Kaplan–Meier method. Results: Median follow-up duration was 45 months. Both 3-year OS and RFS rates were 81%. Proportions of patients who tolerated each scheduled treatment were 94% for RT, 63% for concurrent chemotherapy and 38% for adjuvant chemotherapy. Conclusions: Our protocol of the cisplatin-based concurrent CRT followed by adjuvant chemotherapy consisting of FP regimen was effective for Japanese patients with NPC. However, the doses and numbers of cycle of chemotherapy need to be modified because of the low compliance rate. Larger numbers of data accumulation and/or multi-institutional trials may be warranted to confirm the efficacy of this protocol.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>16905756</pmid><doi>10.1093/jjco/hyl083</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Anemia - chemically induced Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Chemotherapy, Adjuvant cisplatin Cisplatin - administration & dosage Cisplatin - adverse effects concurrent chemoradiotherapy Deglutition Disorders Drug Administration Schedule Feasibility Studies Female Fluorouracil - administration & dosage Fluorouracil - adverse effects Humans Intergroup Study 0099 Male Middle Aged nasopharyngeal carcinoma Nasopharyngeal Neoplasms - drug therapy Nasopharyngeal Neoplasms - pathology Nasopharyngeal Neoplasms - radiotherapy Neoadjuvant Therapy Neoplasm Staging Neutropenia - chemically induced radiotherapy Radiotherapy Dosage Survival Rate |
| title | Efficacy and Feasibility of Cisplatin-Based Concurrent Chemoradiotherapy for Nasopharyngeal Carcinoma |
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