The Tissue Plasminogen Activator (tPA)/Plasmin Extracellular Proteolytic System Regulates Seizure-Induced Hippocampal Mossy Fiber Outgrowth through a Proteoglycan Substrate

Short seizure episodes are associated with remodeling of neuronal connections. One region where such reorganization occurs is the hippocampus, and in particular, the mossy fiber pathway. Using genetic and pharmacological approaches, we show here a critical role in vivo for tissue plasminogen activat...

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Veröffentlicht in:	The Journal of cell biology 2000-03, Vol.148 (6), p.1295-1304
Hauptverfasser:	Wu, Yan Ping, Siao, Chia-Jen, Lu, Weiquan, Sung, Tsung-Chang, Frohman, Michael A., Milev, Peter, Bugge, Thomas H., Degen, Jay L., Levine, Joel M., Margolis, Richard U., Tsirka, Stella E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala Amygdala - drug effects Amygdala - physiology Amygdala - physiopathology Animals Axons Cellular biology Chondroitin Sulfate Proteoglycans - physiology Convulsions & seizures Enzymes Fibrinolysin - metabolism Genetics Hippocampus Hippocampus - physiology Hippocampus - physiopathology Hippocampus - ultrastructure Kainic Acid - pharmacology Mice Mice, Inbred C57BL Mice, Knockout Nerve Fibers - drug effects Nerve Fibers - physiology Nerve Fibers - ultrastructure Neural cell adhesion molecules Neurites Neurites - drug effects Neurites - physiology Neurites - ultrastructure Neurons Neuroscience Pharmacology Plasminogen - deficiency Plasminogen - genetics Plasminogen - metabolism Plasminogen activators Proteoglycans Receptor-Like Protein Tyrosine Phosphatases, Class 5 Seizures - chemically induced Seizures - physiopathology Sprouting Tissue Plasminogen Activator - deficiency Tissue Plasminogen Activator - genetics Tissue Plasminogen Activator - metabolism
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