Magnetic resonance imaging findings in a case of cytarabine-induced myelopathy
A 44-year-old white male with an isolated central nervous system relapse of acute lymphoblastic leukemia was treated with intrathecal cytarabine. He developed Staphylococcus epidermidis meningitis, which was treated successfully with intrathecal vancomycin. Four weeks after the initiation of intrath...
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| Veröffentlicht in: | Military medicine 2002-02, Vol.167 (2), p.157-160 |
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| creator | SHERMAN, Paul M BELDEN, Clifford J NELSON, Douglas A |
| description | A 44-year-old white male with an isolated central nervous system relapse of acute lymphoblastic leukemia was treated with intrathecal cytarabine. He developed Staphylococcus epidermidis meningitis, which was treated successfully with intrathecal vancomycin. Four weeks after the initiation of intrathecal cytarabine, the patient developed progressive ascending paralysis to the upper cervical level. Initial magnetic resonance imaging of the brain and spine were normal, and cerebrospinal fluid evaluation showed no evidence of ongoing infection and clearance of lymphoblasts. Three weeks later, magnetic resonance imaging demonstrated marked edema and peripheral enhancement of the spinal cord, consistent with cytarabine toxicity. |
| doi_str_mv | 10.1093/milmed/167.2.157 |
| format | Article |
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He developed Staphylococcus epidermidis meningitis, which was treated successfully with intrathecal vancomycin. Four weeks after the initiation of intrathecal cytarabine, the patient developed progressive ascending paralysis to the upper cervical level. Initial magnetic resonance imaging of the brain and spine were normal, and cerebrospinal fluid evaluation showed no evidence of ongoing infection and clearance of lymphoblasts. Three weeks later, magnetic resonance imaging demonstrated marked edema and peripheral enhancement of the spinal cord, consistent with cytarabine toxicity.</description><identifier>ISSN: 0026-4075</identifier><identifier>EISSN: 1930-613X</identifier><identifier>DOI: 10.1093/milmed/167.2.157</identifier><identifier>PMID: 11873541</identifier><identifier>CODEN: MMEDA9</identifier><language>eng</language><publisher>Bethesda, MD: Association of Military Surgeons</publisher><subject>Adult ; Biological and medical sciences ; Cytarabine - adverse effects ; Humans ; Immunosuppressive Agents - adverse effects ; Injections, Spinal ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Military Personnel ; Nervous system ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy ; Quadriplegia - chemically induced ; Quadriplegia - diagnosis ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Spinal Cord Diseases - chemically induced ; Spinal Cord Diseases - diagnosis</subject><ispartof>Military medicine, 2002-02, Vol.167 (2), p.157-160</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright Association of Military Surgeons of the United States Feb 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-754de3385a2b9a947d2a3dd895c1d21b95cfcfa0798f19316e73dd8ba7b7f5543</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13518762$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11873541$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SHERMAN, Paul M</creatorcontrib><creatorcontrib>BELDEN, Clifford J</creatorcontrib><creatorcontrib>NELSON, Douglas A</creatorcontrib><title>Magnetic resonance imaging findings in a case of cytarabine-induced myelopathy</title><title>Military medicine</title><addtitle>Mil Med</addtitle><description>A 44-year-old white male with an isolated central nervous system relapse of acute lymphoblastic leukemia was treated with intrathecal cytarabine. He developed Staphylococcus epidermidis meningitis, which was treated successfully with intrathecal vancomycin. Four weeks after the initiation of intrathecal cytarabine, the patient developed progressive ascending paralysis to the upper cervical level. Initial magnetic resonance imaging of the brain and spine were normal, and cerebrospinal fluid evaluation showed no evidence of ongoing infection and clearance of lymphoblasts. Three weeks later, magnetic resonance imaging demonstrated marked edema and peripheral enhancement of the spinal cord, consistent with cytarabine toxicity.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cytarabine - adverse effects</subject><subject>Humans</subject><subject>Immunosuppressive Agents - adverse effects</subject><subject>Injections, Spinal</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Military Personnel</subject><subject>Nervous system</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy</subject><subject>Quadriplegia - chemically induced</subject><subject>Quadriplegia - diagnosis</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Spinal Cord Diseases - chemically induced</subject><subject>Spinal Cord Diseases - diagnosis</subject><issn>0026-4075</issn><issn>1930-613X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpFkDtPwzAURi0EoqWwMyELiTGtH3Ecj6jiJRVYQGKzHMcurhKn2MmQf4-rRjB9w3fuvboHgGuMlhgJumpd05p6hQu-JEvM-AmYY0FRVmD6dQrmCJEiyxFnM3AR4w4hnIsSn4MZxiWnLMdz8Paqtt70TsNgYueV1wa6Vm2d30LrfJ0yQuehglpFAzsL9diroCrnTZb6QZsatqNpur3qv8dLcGZVE83VlAvw-fjwsX7ONu9PL-v7TaapyPuMs7w2lJZMkUookfOaKFrXpWAa1wRXKa22CnFR2vQQLgw_1JXiFbeM5XQBbo9796H7GUzs5a4bgk8nJcEcsZJwniB0hHToYgzGyn1Iv4VRYiQP_uTRn0z-JJHJXxq5mfYO1aH5G5iEJeBuAlTUqrEhGXPxn6MskQWhv-d8eho</recordid><startdate>20020201</startdate><enddate>20020201</enddate><creator>SHERMAN, Paul M</creator><creator>BELDEN, Clifford J</creator><creator>NELSON, Douglas A</creator><general>Association of Military Surgeons</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88F</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M1Q</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope></search><sort><creationdate>20020201</creationdate><title>Magnetic resonance imaging findings in a case of cytarabine-induced myelopathy</title><author>SHERMAN, Paul M ; BELDEN, Clifford J ; NELSON, Douglas A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-754de3385a2b9a947d2a3dd895c1d21b95cfcfa0798f19316e73dd8ba7b7f5543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cytarabine - adverse effects</topic><topic>Humans</topic><topic>Immunosuppressive Agents - adverse effects</topic><topic>Injections, Spinal</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Military Personnel</topic><topic>Nervous system</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy</topic><topic>Quadriplegia - chemically induced</topic><topic>Quadriplegia - diagnosis</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Spinal Cord Diseases - chemically induced</topic><topic>Spinal Cord Diseases - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SHERMAN, Paul M</creatorcontrib><creatorcontrib>BELDEN, Clifford J</creatorcontrib><creatorcontrib>NELSON, Douglas A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Military Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Military Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><jtitle>Military medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHERMAN, Paul M</au><au>BELDEN, Clifford J</au><au>NELSON, Douglas A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic resonance imaging findings in a case of cytarabine-induced myelopathy</atitle><jtitle>Military medicine</jtitle><addtitle>Mil Med</addtitle><date>2002-02-01</date><risdate>2002</risdate><volume>167</volume><issue>2</issue><spage>157</spage><epage>160</epage><pages>157-160</pages><issn>0026-4075</issn><eissn>1930-613X</eissn><coden>MMEDA9</coden><abstract>A 44-year-old white male with an isolated central nervous system relapse of acute lymphoblastic leukemia was treated with intrathecal cytarabine. 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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Biological and medical sciences Cytarabine - adverse effects Humans Immunosuppressive Agents - adverse effects Injections, Spinal Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Male Medical sciences Military Personnel Nervous system Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Quadriplegia - chemically induced Quadriplegia - diagnosis Radiodiagnosis. Nmr imagery. Nmr spectrometry Spinal Cord Diseases - chemically induced Spinal Cord Diseases - diagnosis |
| title | Magnetic resonance imaging findings in a case of cytarabine-induced myelopathy |
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