Neuroprotective effect of agmatine (decarboxylated l-arginine) against oxidative stress and neuroinflammation in rotenone model of Parkinson’s disease

Parkinson’s disease (PD) is the second most common age-related neurodegenerative disease after Alzheimer’s disease, characterized by loss of dopaminergic neurons in substantia nigra pars compacta, accompanied by motor and nonmotor symptoms. The neuropathological hallmarks of PD are well reported, bu...

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Veröffentlicht in:	Human & experimental toxicology 2019-02, Vol.38 (2), p.173-184
Hauptverfasser:	El-Sayed, EK, Ahmed, AAE, Morsy, EM El, Nofal, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Agmatine Agmatine - pharmacology Agmatine - therapeutic use Animals Antioxidants Arginine Body weight Cylinders Cytokines Cytokines - metabolism Disease Models, Animal Dopamine receptors Etiology Glial fibrillary acidic protein Glial Fibrillary Acidic Protein - metabolism Glutathione - metabolism Hydroxylase Inflammation Interleukins Lipid peroxidation Lipids Male Malondialdehyde Malondialdehyde - metabolism Mesencephalon Mesencephalon - drug effects Mesencephalon - metabolism Mitochondria Movement disorders Neurodegenerative diseases Neurological diseases Neurons Neuroprotection Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Oxidative stress Oxidative Stress - drug effects Parkinson Disease, Secondary - chemically induced Parkinson Disease, Secondary - drug therapy Parkinson Disease, Secondary - metabolism Parkinson's disease Peroxidation Proteins Rats, Sprague-Dawley Rot Rotenone Substantia nigra Tumor necrosis factor-α Tyrosine Tyrosine 3-Monooxygenase - metabolism
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