Characterization of the metal status of natively purified alpha-synuclein from human blood, brain tissue, or recombinant sources using size exclusion ICP-MS reveals no significant binding of Cu, Fe or Zn

Abnormal protein structure and function have been implicated as the toxic species in many diseases including neurodegenerative diseases, such as Parkinson's. One key pathological hallmark in Parkinson's disease is the formation of Lewy bodies, of which alpha-synuclein is the major componen...

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Veröffentlicht in:	Metallomics 2019-01, Vol.11 (1), p.128-140
Hauptverfasser:	Lothian, Amber, Lago, Larissa, Mukherjee, Soumya, Connor, Andrea R, Fowler, Chris, McLean, Catriona A, Horne, Malcolm, Masters, Colin L, Cappai, Roberto, Roberts, Blaine R
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - chemistry alpha-Synuclein - metabolism Binding Binding Sites Brain Brain - metabolism Brain Chemistry Copper Copper - analysis Copper - metabolism Crosslinking Dopamine Erythrocytes Erythrocytes - chemistry Erythrocytes - metabolism Humans Hydrogen peroxide Inductively coupled plasma mass spectrometry Iron Iron - analysis Iron - metabolism Lewy bodies Lipid peroxidation Lipids Mass spectrometry Mass Spectrometry - methods Mass spectroscopy Metals Movement disorders Mutants Neurodegenerative diseases Neurological diseases Neurotoxicity Oligomerization Oligomers Oxidative stress Parkinson's disease Protein Binding Protein Multimerization Protein structure Proteins Recombinant Proteins - chemistry Recombinant Proteins - metabolism Size exclusion chromatography Structure-function relationships Synuclein Tissues Toxic diseases Zinc Zinc - analysis Zinc - metabolism
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