DOES PLACEBO LOWER BLOOD-PRESSURE?
The effect of placebo on blood-pressure levels in 20 hypertensive patients was examined as part of a double-blind randomised controlled trial with indoramin. Blood-pressure was measured by both standard sphygmomanometry and ambulant intra-arterial monitoring. Blood-pressure reduction during the plac...
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| Veröffentlicht in: | The Lancet (British edition) 1981-12, Vol.318 (8260-8261), p.1377-1381 |
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| container_issue | 8260-8261 |
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| container_title | The Lancet (British edition) |
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| creator | Gould, BrianA Davies, AnthonyB Mann, Stewart Altman, DouglasG Raftery, EdwardB |
| description | The effect of placebo on blood-pressure levels in 20 hypertensive patients was examined as part of a double-blind randomised controlled trial with indoramin. Blood-pressure was measured by both standard sphygmomanometry and ambulant intra-arterial monitoring. Blood-pressure reduction during the placebo phase, as measured by sphygmomanometry in the outpatient clinic, was highly significant for both systolic and diastolic pressures. In the same subjects, concomitant assessment by ambulatory monitoring showed no significant effect of placebo on intra-arterial pressure. After indoramin treatment blood-pressures measured in the clinic showed a mean reduction of 6/8 mm Hg whereas intra-arterial monitoring showed mean reductions of 18/13 mm Hg. The placebo response, therefore, appears to be an artifact of clinic blood-pressure measurement and its use as a control value in pharmacological trials may lead to serious underestimation of the efficacy of the active drug. |
| doi_str_mv | 10.1016/S0140-6736(81)92799-9 |
| format | Article |
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Blood-pressure was measured by both standard sphygmomanometry and ambulant intra-arterial monitoring. Blood-pressure reduction during the placebo phase, as measured by sphygmomanometry in the outpatient clinic, was highly significant for both systolic and diastolic pressures. In the same subjects, concomitant assessment by ambulatory monitoring showed no significant effect of placebo on intra-arterial pressure. After indoramin treatment blood-pressures measured in the clinic showed a mean reduction of 6/8 mm Hg whereas intra-arterial monitoring showed mean reductions of 18/13 mm Hg. The placebo response, therefore, appears to be an artifact of clinic blood-pressure measurement and its use as a control value in pharmacological trials may lead to serious underestimation of the efficacy of the active drug.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(81)92799-9</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Antigens ; Blood ; Blood pressure ; Clinical trials ; Immunology ; Infections ; Leprosy ; Lymphocytes ; Monitoring ; Monoclonal antibodies ; Patients ; Pharmacology ; Pressure effects ; Pressure measurement ; Pressure reduction</subject><ispartof>The Lancet (British edition), 1981-12, Vol.318 (8260-8261), p.1377-1381</ispartof><rights>1981</rights><rights>Copyright Elsevier Limited Dec 26, 1981</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c250t-add0a4200119f7c78f834dd5af21028ea8064b09cfbc39d577530f2625ebc3453</citedby><cites>FETCH-LOGICAL-c250t-add0a4200119f7c78f834dd5af21028ea8064b09cfbc39d577530f2625ebc3453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0140-6736(81)92799-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Gould, BrianA</creatorcontrib><creatorcontrib>Davies, AnthonyB</creatorcontrib><creatorcontrib>Mann, Stewart</creatorcontrib><creatorcontrib>Altman, DouglasG</creatorcontrib><creatorcontrib>Raftery, EdwardB</creatorcontrib><title>DOES PLACEBO LOWER BLOOD-PRESSURE?</title><title>The Lancet (British edition)</title><description>The effect of placebo on blood-pressure levels in 20 hypertensive patients was examined as part of a double-blind randomised controlled trial with indoramin. 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The placebo response, therefore, appears to be an artifact of clinic blood-pressure measurement and its use as a control value in pharmacological trials may lead to serious underestimation of the efficacy of the active drug.</description><subject>Antigens</subject><subject>Blood</subject><subject>Blood pressure</subject><subject>Clinical trials</subject><subject>Immunology</subject><subject>Infections</subject><subject>Leprosy</subject><subject>Lymphocytes</subject><subject>Monitoring</subject><subject>Monoclonal antibodies</subject><subject>Patients</subject><subject>Pharmacology</subject><subject>Pressure effects</subject><subject>Pressure measurement</subject><subject>Pressure reduction</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><recordid>eNqFkEtLw0AUhQdRsFZ_glB0o4vRO5N5ZFalTeMDAimNRXdDOg9I0abOtIL_3rQVt64uHL5zLucgdEngjgAR9xUQBljIRNyk5FZRqRRWR6hHmGSYM_l2jHp_yCk6i3EJAEwA76GrSZlXg2kxyvJxOSjK13w2GBdlOcHTWV5V81k-PEcnvn6P7uL39tH8IX_JnnBRPj5nowIbymGDa2uhZhSAEOWlkalPE2Ytrz0lQFNXpyDYApTxC5Moy6XkCXgqKHedwHjSR9eH3HVoP7cubvSy3YZV91JTIpQkCVWqo_iBMqGNMTiv16H5qMO3JqB3c-j9HHrXVadE7-fQO9_w4HNdha_GBR1N41bG2SY4s9G2bf5J-AHwQmGa</recordid><startdate>19811226</startdate><enddate>19811226</enddate><creator>Gould, BrianA</creator><creator>Davies, AnthonyB</creator><creator>Mann, Stewart</creator><creator>Altman, DouglasG</creator><creator>Raftery, EdwardB</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>ASE</scope><scope>C1K</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>KB~</scope><scope>M7N</scope><scope>NAPCQ</scope></search><sort><creationdate>19811226</creationdate><title>DOES PLACEBO LOWER BLOOD-PRESSURE?</title><author>Gould, BrianA ; Davies, AnthonyB ; Mann, Stewart ; Altman, DouglasG ; Raftery, EdwardB</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c250t-add0a4200119f7c78f834dd5af21028ea8064b09cfbc39d577530f2625ebc3453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Antigens</topic><topic>Blood</topic><topic>Blood pressure</topic><topic>Clinical trials</topic><topic>Immunology</topic><topic>Infections</topic><topic>Leprosy</topic><topic>Lymphocytes</topic><topic>Monitoring</topic><topic>Monoclonal antibodies</topic><topic>Patients</topic><topic>Pharmacology</topic><topic>Pressure effects</topic><topic>Pressure measurement</topic><topic>Pressure reduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gould, BrianA</creatorcontrib><creatorcontrib>Davies, AnthonyB</creatorcontrib><creatorcontrib>Mann, Stewart</creatorcontrib><creatorcontrib>Altman, DouglasG</creatorcontrib><creatorcontrib>Raftery, EdwardB</creatorcontrib><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>Environmental Sciences and Pollution Management</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Newsstand Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gould, BrianA</au><au>Davies, AnthonyB</au><au>Mann, Stewart</au><au>Altman, DouglasG</au><au>Raftery, EdwardB</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DOES PLACEBO LOWER BLOOD-PRESSURE?</atitle><jtitle>The Lancet (British edition)</jtitle><date>1981-12-26</date><risdate>1981</risdate><volume>318</volume><issue>8260-8261</issue><spage>1377</spage><epage>1381</epage><pages>1377-1381</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><abstract>The effect of placebo on blood-pressure levels in 20 hypertensive patients was examined as part of a double-blind randomised controlled trial with indoramin. 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| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 1981-12, Vol.318 (8260-8261), p.1377-1381 |
| issn | 0140-6736 1474-547X |
| language | eng |
| recordid | cdi_proquest_journals_2169713299 |
| source | Elsevier ScienceDirect Journals Complete |
| subjects | Antigens Blood Blood pressure Clinical trials Immunology Infections Leprosy Lymphocytes Monitoring Monoclonal antibodies Patients Pharmacology Pressure effects Pressure measurement Pressure reduction |
| title | DOES PLACEBO LOWER BLOOD-PRESSURE? |
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