Snake venoms promote stress‐induced senescence in human fibroblasts

Snake venoms are widely studied in terms of their systemic toxicity and proteolytic, hemotoxic, neurotoxic, and cytotoxic activities. However, little is known about snake‐venom‐mediated effects when used at low, noncytotoxic concentrations. In the current study, two human fibroblast cell lines of di...

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Veröffentlicht in:	Journal of cellular physiology 2019-05, Vol.234 (5), p.6147-6160
Hauptverfasser:	Lewinska, Anna, Bocian, Aleksandra, Petrilla, Vladimir, Adamczyk‐Grochala, Jagoda, Szymura, Karolina, Hendzel, Wiktoria, Kaleniuk, Edyta, Hus, Konrad K., Petrillova, Monika, Wnuk, Maciej
Format:	Artikel
Sprache:	eng
Schlagworte:	Agkistrodon contortrix Animals Cell cycle Cell lines Cell migration Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects cellular senescence Cellular Senescence - drug effects Cytotoxicity Dendroaspis viridis Deoxyribonucleic acid DNA DNA damage DNA Damage - drug effects Fetuses Fibroblasts Fibroblasts - drug effects FOXO3 protein Gene Expression Regulation - drug effects Humans Lungs mRNA Naja melanoleuca Naja siamensis Neurotoxicity Oxidative stress Oxidative Stress - drug effects oxidative stress and DNA damage response (DDR) proliferation Proteins Proteolysis Regulators Ribonucleic acid RNA Senescence snake venoms Snake Venoms - pharmacology Snakes Toxicity Venom Venom toxins
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