Ganoderma lucidum polysaccharide inhibits UVB‐induced melanogenesis by antagonizing cAMP/PKA and ROS/MAPK signaling pathways
Ultraviolet (UV)‐induced pigmentation is very common in clinical practice, but the current treatments are rarely effective, accompanied by some side effects. Ganoderma lucidum polysaccharide (GLP) is a natural antioxidant with no toxic side effects, which can antagonize UVB‐induced fibroblast photo...
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| Veröffentlicht in: | Journal of cellular physiology 2019-05, Vol.234 (5), p.7330-7340 |
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| creator | Hu, Shuanghai Huang, Jinhua Pei, Shiyao Ouyang, Yujie Ding, Yufang Jiang, Ling Lu, Jianyun Kang, Liyang Huang, Lihua Xiang, Hong Xiao, Rong Zeng, Qinghai Chen, Jing |
| description | Ultraviolet (UV)‐induced pigmentation is very common in clinical practice, but the current treatments are rarely effective, accompanied by some side effects. Ganoderma lucidum polysaccharide (GLP) is a natural antioxidant with no toxic side effects, which can antagonize UVB‐induced fibroblast photo aging. The study aims to explore the role of GLP in inhibiting UVB‐induced melanogenesis and its possible mechanism. The expression of melanogenesis genes such as microphthalmia‐associated transcription factor (MITF), tyrosine (TYR), tyrosinase related protein 1 (TYRP1), tyrosinase related protein 2 (TYRP2), ras‐related protein Rab‐27A (Rab27A), and Myosin shows an upward trend after exposure of B16F10 and PIG1 cells to UVB irradiation, but GLP can downregulate the expression of genes related to UVB‐induced melanogenesis. GLP can inhibit UVB‐activated protein kinase A (PKA) and mitogen‐activated protein kinase (MAPK) signaling pathways. Besides, GLP protects mitochondria from UVB damage and inhibits reactive oxygen species (ROS) production. Also, UVB‐induced cyclic adenosine monophosphate (cAMP) can be inhibited. It has been found in the experiments of UVB‐induced skin pigmentation in zebrafish that GLP is capable of inhibiting UVB‐induced skin pigmentation. Meanwhile, it can greatly relieve erythema reaction in guinea pig skin caused by high‐dosage UVB irradiation. In conclusion, this study shows that GLP can inhibit UVB‐induced melanogenesis by antagonizing cAMP/PKA and ROS/MAPK signaling pathways and is a potential natural safe whitening sunscreen additive.
This study is the first to explore the role of Ganoderma lucidum polysaccharide (GLP) in inhibiting Ultraviolet B (UVB)‐induced melanogenesis and its possible mechanism. we found that GLP could inhibit UVB‐induced melanogenesis by antagonizing cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) and reactive oxygen species/mitogen‐activated protein kinase (ROS/MAPK) signaling pathways and is a potential natural safe whitening sunscreen additive |
| doi_str_mv | 10.1002/jcp.27492 |
| format | Article |
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This study is the first to explore the role of Ganoderma lucidum polysaccharide (GLP) in inhibiting Ultraviolet B (UVB)‐induced melanogenesis and its possible mechanism. we found that GLP could inhibit UVB‐induced melanogenesis by antagonizing cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) and reactive oxygen species/mitogen‐activated protein kinase (ROS/MAPK) signaling pathways and is a potential natural safe whitening sunscreen additive</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.27492</identifier><identifier>PMID: 30362532</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adenosine monophosphate ; Aging ; Aging (natural) ; Animals ; Antioxidants ; Cell Line, Tumor ; Cyclic AMP ; Cyclic AMP - metabolism ; Cyclic AMP-Dependent Protein Kinases - metabolism ; Erythema ; Ganoderma lucidum ; Ganoderma lucidum polysaccharide (GLP) ; Gene expression ; Genes ; Guinea pigs ; Humans ; Irradiation ; Kinases ; MAP kinase ; Melanins - biosynthesis ; Melanocytes - drug effects ; Melanocytes - enzymology ; Melanocytes - radiation effects ; melanogenesis ; Melanoma, Experimental ; Mice ; Microphthalmia-associated transcription factor ; Mitochondria ; Mitogen-Activated Protein Kinases - metabolism ; mitogen‐activated protein kinase signaling pathway (MAPK) ; Mushrooms ; Myosin ; Pigmentation ; Pigskins ; Polysaccharides ; Polysaccharides - isolation & purification ; Polysaccharides - pharmacology ; Protein kinase A ; protein kinase A (PKA) signaling pathway ; Proteins ; Radiation dosage ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; Reishi - chemistry ; Side effects ; Signal Transduction ; Signaling ; Skin ; Skin Lightening Preparations - isolation & purification ; Skin Lightening Preparations - pharmacology ; Skin pigmentation ; Skin Pigmentation - drug effects ; Skin Pigmentation - radiation effects ; Sun screens ; Sunscreening Agents - isolation & purification ; Sunscreening Agents - pharmacology ; Tyrosinase ; Tyrosine ; ultraviolet B (UVB) ; Ultraviolet radiation ; Ultraviolet Rays ; Zebrafish</subject><ispartof>Journal of cellular physiology, 2019-05, Vol.234 (5), p.7330-7340</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3532-6ac733ff2dc1650ca568b30730db4689a248affd22ca1f01a2cd4e8a78c7fc713</citedby><cites>FETCH-LOGICAL-c3532-6ac733ff2dc1650ca568b30730db4689a248affd22ca1f01a2cd4e8a78c7fc713</cites><orcidid>0000-0002-6747-1486</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.27492$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.27492$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30362532$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Shuanghai</creatorcontrib><creatorcontrib>Huang, Jinhua</creatorcontrib><creatorcontrib>Pei, Shiyao</creatorcontrib><creatorcontrib>Ouyang, Yujie</creatorcontrib><creatorcontrib>Ding, Yufang</creatorcontrib><creatorcontrib>Jiang, Ling</creatorcontrib><creatorcontrib>Lu, Jianyun</creatorcontrib><creatorcontrib>Kang, Liyang</creatorcontrib><creatorcontrib>Huang, Lihua</creatorcontrib><creatorcontrib>Xiang, Hong</creatorcontrib><creatorcontrib>Xiao, Rong</creatorcontrib><creatorcontrib>Zeng, Qinghai</creatorcontrib><creatorcontrib>Chen, Jing</creatorcontrib><title>Ganoderma lucidum polysaccharide inhibits UVB‐induced melanogenesis by antagonizing cAMP/PKA and ROS/MAPK signaling pathways</title><title>Journal of cellular physiology</title><addtitle>J Cell Physiol</addtitle><description>Ultraviolet (UV)‐induced pigmentation is very common in clinical practice, but the current treatments are rarely effective, accompanied by some side effects. Ganoderma lucidum polysaccharide (GLP) is a natural antioxidant with no toxic side effects, which can antagonize UVB‐induced fibroblast photo aging. The study aims to explore the role of GLP in inhibiting UVB‐induced melanogenesis and its possible mechanism. The expression of melanogenesis genes such as microphthalmia‐associated transcription factor (MITF), tyrosine (TYR), tyrosinase related protein 1 (TYRP1), tyrosinase related protein 2 (TYRP2), ras‐related protein Rab‐27A (Rab27A), and Myosin shows an upward trend after exposure of B16F10 and PIG1 cells to UVB irradiation, but GLP can downregulate the expression of genes related to UVB‐induced melanogenesis. GLP can inhibit UVB‐activated protein kinase A (PKA) and mitogen‐activated protein kinase (MAPK) signaling pathways. Besides, GLP protects mitochondria from UVB damage and inhibits reactive oxygen species (ROS) production. Also, UVB‐induced cyclic adenosine monophosphate (cAMP) can be inhibited. It has been found in the experiments of UVB‐induced skin pigmentation in zebrafish that GLP is capable of inhibiting UVB‐induced skin pigmentation. Meanwhile, it can greatly relieve erythema reaction in guinea pig skin caused by high‐dosage UVB irradiation. In conclusion, this study shows that GLP can inhibit UVB‐induced melanogenesis by antagonizing cAMP/PKA and ROS/MAPK signaling pathways and is a potential natural safe whitening sunscreen additive.
This study is the first to explore the role of Ganoderma lucidum polysaccharide (GLP) in inhibiting Ultraviolet B (UVB)‐induced melanogenesis and its possible mechanism. we found that GLP could inhibit UVB‐induced melanogenesis by antagonizing cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) and reactive oxygen species/mitogen‐activated protein kinase (ROS/MAPK) signaling pathways and is a potential natural safe whitening sunscreen additive</description><subject>Adenosine monophosphate</subject><subject>Aging</subject><subject>Aging (natural)</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Cell Line, Tumor</subject><subject>Cyclic AMP</subject><subject>Cyclic AMP - metabolism</subject><subject>Cyclic AMP-Dependent Protein Kinases - metabolism</subject><subject>Erythema</subject><subject>Ganoderma lucidum</subject><subject>Ganoderma lucidum polysaccharide (GLP)</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Guinea pigs</subject><subject>Humans</subject><subject>Irradiation</subject><subject>Kinases</subject><subject>MAP kinase</subject><subject>Melanins - biosynthesis</subject><subject>Melanocytes - drug effects</subject><subject>Melanocytes - enzymology</subject><subject>Melanocytes - radiation effects</subject><subject>melanogenesis</subject><subject>Melanoma, Experimental</subject><subject>Mice</subject><subject>Microphthalmia-associated transcription factor</subject><subject>Mitochondria</subject><subject>Mitogen-Activated Protein Kinases - metabolism</subject><subject>mitogen‐activated protein kinase signaling pathway (MAPK)</subject><subject>Mushrooms</subject><subject>Myosin</subject><subject>Pigmentation</subject><subject>Pigskins</subject><subject>Polysaccharides</subject><subject>Polysaccharides - isolation & purification</subject><subject>Polysaccharides - pharmacology</subject><subject>Protein kinase A</subject><subject>protein kinase A (PKA) signaling pathway</subject><subject>Proteins</subject><subject>Radiation dosage</subject><subject>Reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Reishi - chemistry</subject><subject>Side effects</subject><subject>Signal Transduction</subject><subject>Signaling</subject><subject>Skin</subject><subject>Skin Lightening Preparations - isolation & purification</subject><subject>Skin Lightening Preparations - pharmacology</subject><subject>Skin pigmentation</subject><subject>Skin Pigmentation - drug effects</subject><subject>Skin Pigmentation - radiation effects</subject><subject>Sun screens</subject><subject>Sunscreening Agents - isolation & purification</subject><subject>Sunscreening Agents - pharmacology</subject><subject>Tyrosinase</subject><subject>Tyrosine</subject><subject>ultraviolet B (UVB)</subject><subject>Ultraviolet radiation</subject><subject>Ultraviolet Rays</subject><subject>Zebrafish</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMlOwzAQhi0EgrIceAFkiROHUC9Zj6VibSsitms0sZ3WVTbiRigcEI_AM_IkuAS4cRpp_m9-jT6EDik5pYSw4VLUpyxwI7aBBpREgeP6HttEA5tRJ_JcuoN2jVkSQqKI8220wwn3mcfZAL1dQllJ1RSA81Zo2Ra4rvLOgBALaLRUWJcLneqVwY9PZ5_vH7qUrVASFyq3l3NVKqMNTjsM5QrmValfdTnHYjSLh_FkZLcS393eD2ejeIKNnpeQr_MaVosX6Mw-2sogN-rgZ-6hx4vzh_GVM729vB6Ppo7g9k3HBxFwnmVMCup7RIDnhyknAScydf0wAuaGkGWSMQE0IxSYkK4KIQhFkImA8j103PfWTfXcKrNKllXb2GdMwqgfMT8kXmSpk54STWVMo7KkbnQBTZdQkqxNJ9Z08m3askc_jW1aKPlH_qq1wLAHXnSuuv-bkptx3Fd-Ac1MiaQ</recordid><startdate>201905</startdate><enddate>201905</enddate><creator>Hu, Shuanghai</creator><creator>Huang, Jinhua</creator><creator>Pei, Shiyao</creator><creator>Ouyang, Yujie</creator><creator>Ding, Yufang</creator><creator>Jiang, Ling</creator><creator>Lu, Jianyun</creator><creator>Kang, Liyang</creator><creator>Huang, Lihua</creator><creator>Xiang, Hong</creator><creator>Xiao, Rong</creator><creator>Zeng, Qinghai</creator><creator>Chen, Jing</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0002-6747-1486</orcidid></search><sort><creationdate>201905</creationdate><title>Ganoderma lucidum polysaccharide inhibits UVB‐induced melanogenesis by antagonizing cAMP/PKA and ROS/MAPK signaling pathways</title><author>Hu, Shuanghai ; Huang, Jinhua ; Pei, Shiyao ; Ouyang, Yujie ; Ding, Yufang ; Jiang, Ling ; Lu, Jianyun ; Kang, Liyang ; Huang, Lihua ; Xiang, Hong ; Xiao, Rong ; Zeng, Qinghai ; Chen, Jing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-6ac733ff2dc1650ca568b30730db4689a248affd22ca1f01a2cd4e8a78c7fc713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adenosine monophosphate</topic><topic>Aging</topic><topic>Aging (natural)</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Cell Line, Tumor</topic><topic>Cyclic AMP</topic><topic>Cyclic AMP - metabolism</topic><topic>Cyclic AMP-Dependent Protein Kinases - metabolism</topic><topic>Erythema</topic><topic>Ganoderma lucidum</topic><topic>Ganoderma lucidum polysaccharide (GLP)</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Guinea pigs</topic><topic>Humans</topic><topic>Irradiation</topic><topic>Kinases</topic><topic>MAP kinase</topic><topic>Melanins - biosynthesis</topic><topic>Melanocytes - drug effects</topic><topic>Melanocytes - enzymology</topic><topic>Melanocytes - radiation effects</topic><topic>melanogenesis</topic><topic>Melanoma, Experimental</topic><topic>Mice</topic><topic>Microphthalmia-associated transcription factor</topic><topic>Mitochondria</topic><topic>Mitogen-Activated Protein Kinases - metabolism</topic><topic>mitogen‐activated protein kinase signaling pathway (MAPK)</topic><topic>Mushrooms</topic><topic>Myosin</topic><topic>Pigmentation</topic><topic>Pigskins</topic><topic>Polysaccharides</topic><topic>Polysaccharides - isolation & purification</topic><topic>Polysaccharides - pharmacology</topic><topic>Protein kinase A</topic><topic>protein kinase A (PKA) signaling pathway</topic><topic>Proteins</topic><topic>Radiation dosage</topic><topic>Reactive oxygen species</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Reishi - chemistry</topic><topic>Side effects</topic><topic>Signal Transduction</topic><topic>Signaling</topic><topic>Skin</topic><topic>Skin Lightening Preparations - isolation & purification</topic><topic>Skin Lightening Preparations - pharmacology</topic><topic>Skin pigmentation</topic><topic>Skin Pigmentation - drug effects</topic><topic>Skin Pigmentation - radiation effects</topic><topic>Sun screens</topic><topic>Sunscreening Agents - isolation & purification</topic><topic>Sunscreening Agents - pharmacology</topic><topic>Tyrosinase</topic><topic>Tyrosine</topic><topic>ultraviolet B (UVB)</topic><topic>Ultraviolet radiation</topic><topic>Ultraviolet Rays</topic><topic>Zebrafish</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Shuanghai</creatorcontrib><creatorcontrib>Huang, Jinhua</creatorcontrib><creatorcontrib>Pei, Shiyao</creatorcontrib><creatorcontrib>Ouyang, Yujie</creatorcontrib><creatorcontrib>Ding, Yufang</creatorcontrib><creatorcontrib>Jiang, Ling</creatorcontrib><creatorcontrib>Lu, Jianyun</creatorcontrib><creatorcontrib>Kang, Liyang</creatorcontrib><creatorcontrib>Huang, Lihua</creatorcontrib><creatorcontrib>Xiang, Hong</creatorcontrib><creatorcontrib>Xiao, Rong</creatorcontrib><creatorcontrib>Zeng, Qinghai</creatorcontrib><creatorcontrib>Chen, Jing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Shuanghai</au><au>Huang, Jinhua</au><au>Pei, Shiyao</au><au>Ouyang, Yujie</au><au>Ding, Yufang</au><au>Jiang, Ling</au><au>Lu, Jianyun</au><au>Kang, Liyang</au><au>Huang, Lihua</au><au>Xiang, Hong</au><au>Xiao, Rong</au><au>Zeng, Qinghai</au><au>Chen, Jing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ganoderma lucidum polysaccharide inhibits UVB‐induced melanogenesis by antagonizing cAMP/PKA and ROS/MAPK signaling pathways</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J Cell Physiol</addtitle><date>2019-05</date><risdate>2019</risdate><volume>234</volume><issue>5</issue><spage>7330</spage><epage>7340</epage><pages>7330-7340</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><abstract>Ultraviolet (UV)‐induced pigmentation is very common in clinical practice, but the current treatments are rarely effective, accompanied by some side effects. Ganoderma lucidum polysaccharide (GLP) is a natural antioxidant with no toxic side effects, which can antagonize UVB‐induced fibroblast photo aging. The study aims to explore the role of GLP in inhibiting UVB‐induced melanogenesis and its possible mechanism. The expression of melanogenesis genes such as microphthalmia‐associated transcription factor (MITF), tyrosine (TYR), tyrosinase related protein 1 (TYRP1), tyrosinase related protein 2 (TYRP2), ras‐related protein Rab‐27A (Rab27A), and Myosin shows an upward trend after exposure of B16F10 and PIG1 cells to UVB irradiation, but GLP can downregulate the expression of genes related to UVB‐induced melanogenesis. GLP can inhibit UVB‐activated protein kinase A (PKA) and mitogen‐activated protein kinase (MAPK) signaling pathways. Besides, GLP protects mitochondria from UVB damage and inhibits reactive oxygen species (ROS) production. Also, UVB‐induced cyclic adenosine monophosphate (cAMP) can be inhibited. It has been found in the experiments of UVB‐induced skin pigmentation in zebrafish that GLP is capable of inhibiting UVB‐induced skin pigmentation. Meanwhile, it can greatly relieve erythema reaction in guinea pig skin caused by high‐dosage UVB irradiation. In conclusion, this study shows that GLP can inhibit UVB‐induced melanogenesis by antagonizing cAMP/PKA and ROS/MAPK signaling pathways and is a potential natural safe whitening sunscreen additive.
This study is the first to explore the role of Ganoderma lucidum polysaccharide (GLP) in inhibiting Ultraviolet B (UVB)‐induced melanogenesis and its possible mechanism. we found that GLP could inhibit UVB‐induced melanogenesis by antagonizing cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) and reactive oxygen species/mitogen‐activated protein kinase (ROS/MAPK) signaling pathways and is a potential natural safe whitening sunscreen additive</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30362532</pmid><doi>10.1002/jcp.27492</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-6747-1486</orcidid></addata></record> |
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| subjects | Adenosine monophosphate Aging Aging (natural) Animals Antioxidants Cell Line, Tumor Cyclic AMP Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Erythema Ganoderma lucidum Ganoderma lucidum polysaccharide (GLP) Gene expression Genes Guinea pigs Humans Irradiation Kinases MAP kinase Melanins - biosynthesis Melanocytes - drug effects Melanocytes - enzymology Melanocytes - radiation effects melanogenesis Melanoma, Experimental Mice Microphthalmia-associated transcription factor Mitochondria Mitogen-Activated Protein Kinases - metabolism mitogen‐activated protein kinase signaling pathway (MAPK) Mushrooms Myosin Pigmentation Pigskins Polysaccharides Polysaccharides - isolation & purification Polysaccharides - pharmacology Protein kinase A protein kinase A (PKA) signaling pathway Proteins Radiation dosage Reactive oxygen species Reactive Oxygen Species - metabolism Reishi - chemistry Side effects Signal Transduction Signaling Skin Skin Lightening Preparations - isolation & purification Skin Lightening Preparations - pharmacology Skin pigmentation Skin Pigmentation - drug effects Skin Pigmentation - radiation effects Sun screens Sunscreening Agents - isolation & purification Sunscreening Agents - pharmacology Tyrosinase Tyrosine ultraviolet B (UVB) Ultraviolet radiation Ultraviolet Rays Zebrafish |
| title | Ganoderma lucidum polysaccharide inhibits UVB‐induced melanogenesis by antagonizing cAMP/PKA and ROS/MAPK signaling pathways |
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