The “Aspirin” of the New Millennium: Cyclooxygenase-2 Inhibitors

Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit prostaglandin synthesis via the cyclooxygenase (COX) enzyme, the key to both therapeutic benefits and toxicity. COX enzyme exists in 2 isoforms, COX-1 and COX-2. COX-1 enzyme is thought to mediate “housekeeping” or homeostatic functions, and COX-...

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Veröffentlicht in:	Mayo Clinic proceedings 2000-10, Vol.75 (10), p.1027-1038
Hauptverfasser:	Buttar, Navtej S., Wang, Kenneth K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Analgesics - therapeutic use Anti-Inflammatory Agents - therapeutic use Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Cyclooxygenase 1 Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - therapeutic use Homeostasis - physiology Humans Inflammation - prevention & control Isoenzymes - antagonists & inhibitors Isoenzymes - physiology Medical sciences Membrane Proteins Neuropharmacology Pain - prevention & control Peroxidases - antagonists & inhibitors Pharmacology. Drug treatments Prostaglandin-Endoperoxide Synthases - physiology
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