Complete Atrioventricular Block Associated With Concomitant Use of Metoprolol and Paroxetine

A 63-year-old woman, who had been treated with 20 mg of paroxetine and 0.5 mg of alprazolam daily for 1 year and with 50 mg of metoprolol daily for 15 days, presented to a facility elsewhere with presyncope and complete atrioventricular block. Three days after her initial presentation and cessation...

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Veröffentlicht in:	Mayo Clinic proceedings 2008-05, Vol.83 (5), p.595-599
Hauptverfasser:	Onalan, Orhan, Cumurcu, Birgul Elbozan, Bekar, Lutfu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - administration & dosage Adrenergic beta-Antagonists - adverse effects Adrenergic beta-Antagonists - metabolism Antihypertensive Agents - administration & dosage Antihypertensive Agents - adverse effects Antihypertensive Agents - metabolism Atrioventricular Block - chemically induced Atrioventricular Node - drug effects Biological and medical sciences Bradycardia - chemically induced Cardiac dysrhythmias Cardiology. Vascular system Case studies Causes of Complications and side effects Cytochrome P-450 CYP2D6 - metabolism Dosage and administration Drug Synergism Drug therapy, Combination Electrocardiography, Ambulatory Female General aspects Heart Heart block Humans Liver - metabolism Medical sciences Metoprolol Metoprolol - administration & dosage Metoprolol - adverse effects Metoprolol - metabolism Middle Aged Paroxetine Paroxetine - administration & dosage Paroxetine - adverse effects Serotonin Uptake Inhibitors - administration & dosage Serotonin Uptake Inhibitors - adverse effects
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