Effect of Roux-en-Y gastric surgery on ciprofloxacin pharmacokinetics: an obvious effect?
Purpose To evaluate pharmacokinetic parameters of ciprofloxacin in patients undergoing Roux-en-Y gastric surgery (RYGS). Methods Controlled, single-dose, open-label study in patients undergoing RYGS. Healthy overweight/obese patients 18–60 years old were included. The assessment was performed once i...
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| Veröffentlicht in: | European journal of clinical pharmacology 2019-05, Vol.75 (5), p.647-654 |
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| creator | Rivas, Ana Belén Lopez-Picado, Amanda Salas-Butrón, María del Rosario Terleira, Ana Sanchez Pernaute, Andres Torres Garcia, Antonio José Moreno Lopera, Carmen Chicharro, Luis Miguel Bandrés, Fernando Rubio Herrera, Miguel Angel Portolés, Antonio Vargas, Emilio |
| description | Purpose
To evaluate pharmacokinetic parameters of ciprofloxacin in patients undergoing Roux-en-Y gastric surgery (RYGS).
Methods
Controlled, single-dose, open-label study in patients undergoing RYGS. Healthy overweight/obese patients 18–60 years old were included. The assessment was performed once in control patients and three times in case patients (before surgery and 1 and 6 months after surgery). In each visit, the subjects received a single oral dose of ciprofloxacin 500 mg. Venous blood samples were obtained at baseline and 0.5, 1, 1.25, 1.5, 1.75, 2, 2.5, 3, 4, 8 and 14 h after ciprofloxacin intake. Pre- and post-surgery variables were compared using paired ANOVA or the Wilcoxon tests and control vs cases using ANOVA or Mann Whitney. Given the post-surgery change in body weight, the parameters were corrected by dose (mg)/body weight (kg). The analysis was performed using SPSS.
Results
Ciprofloxacin
C
max
was significantly reduced 1 month after surgery (1840.9 ± 485.2 vs 1589.6 ± 321.8 ng/ml;
p
= 0.032) but not 6 months after.
C
max
on the sixth month was lower than
C
max
in control group (2160.4 ± 408.6 vs 1589.6 ± 321.8 ng/ml;
p
|
| doi_str_mv | 10.1007/s00228-018-02623-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2167526132</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2167526132</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-84137dcc367393798a22139f235a8be8e9c6bd7a36eeafcecca03d764fbe40253</originalsourceid><addsrcrecordid>eNp9kEtLxDAQx4Mo7vr4Ah4k4Dk6ybRJ60Vk8QWCIHrwFNJsotXdZk1aWb-90fVx8zDMYf6P4UfIHodDDqCOEoAQFQOeR0iBrFojY16gYBwKvk7GAMiZrBWMyFZKzwC8rAE3yQhBFrUEMSYPZ94729Pg6W0Ylsx17IE-mtTH1tI0xEcX32noqG0XMfhZWBrbdnTxZOLc2PDSdq5vbTqmpqOheWvDkKj7SjzZIRvezJLb_d7b5P787G5yya5vLq4mp9fMoip7VhUc1dRalAprVHVlhOBYe4GlqRpXudrKZqoMSueMt85aAzhVsvCNK0CUuE0OVrn5wdfBpV4_hyF2uVILLlUpJEeRVWKlsjGkFJ3Xi9jOTXzXHPQnTb2iqTNN_UVTV9m0_x09NHM3_bX84MsCXAlSPnWZ1V_3P7EfecJ__w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2167526132</pqid></control><display><type>article</type><title>Effect of Roux-en-Y gastric surgery on ciprofloxacin pharmacokinetics: an obvious effect?</title><source>SpringerNature Complete Journals</source><creator>Rivas, Ana Belén ; Lopez-Picado, Amanda ; Salas-Butrón, María del Rosario ; Terleira, Ana ; Sanchez Pernaute, Andres ; Torres Garcia, Antonio José ; Moreno Lopera, Carmen ; Chicharro, Luis Miguel ; Bandrés, Fernando ; Rubio Herrera, Miguel Angel ; Portolés, Antonio ; Vargas, Emilio</creator><creatorcontrib>Rivas, Ana Belén ; Lopez-Picado, Amanda ; Salas-Butrón, María del Rosario ; Terleira, Ana ; Sanchez Pernaute, Andres ; Torres Garcia, Antonio José ; Moreno Lopera, Carmen ; Chicharro, Luis Miguel ; Bandrés, Fernando ; Rubio Herrera, Miguel Angel ; Portolés, Antonio ; Vargas, Emilio</creatorcontrib><description>Purpose
To evaluate pharmacokinetic parameters of ciprofloxacin in patients undergoing Roux-en-Y gastric surgery (RYGS).
Methods
Controlled, single-dose, open-label study in patients undergoing RYGS. Healthy overweight/obese patients 18–60 years old were included. The assessment was performed once in control patients and three times in case patients (before surgery and 1 and 6 months after surgery). In each visit, the subjects received a single oral dose of ciprofloxacin 500 mg. Venous blood samples were obtained at baseline and 0.5, 1, 1.25, 1.5, 1.75, 2, 2.5, 3, 4, 8 and 14 h after ciprofloxacin intake. Pre- and post-surgery variables were compared using paired ANOVA or the Wilcoxon tests and control vs cases using ANOVA or Mann Whitney. Given the post-surgery change in body weight, the parameters were corrected by dose (mg)/body weight (kg). The analysis was performed using SPSS.
Results
Ciprofloxacin
C
max
was significantly reduced 1 month after surgery (1840.9 ± 485.2 vs 1589.6 ± 321.8 ng/ml;
p
= 0.032) but not 6 months after.
C
max
on the sixth month was lower than
C
max
in control group (2160.4 ± 408.6 vs 1589.6 ± 321.8 ng/ml;
p
< 0.001). After correcting by the dose (mg)/patient’s body weight, both
C
max
and AUClast showed significant decrease 1 and 6 months after surgery:
C
max
, 289.1 ± 65.3 and 263.5 ± 52.1 (ng/ml)/(dose (mg)/weight (kg)) respectively vs 429.3 ± 127.6 (ng/ml)/(dose (mg)/weight (kg)) at baseline; AUC, 1340.6 ± 243.0 and 1299.2 ± 415.4 (h
×
ng/ml)/(dose (mg)/weight (kg)) respectively vs 1896.7 ± 396.8 (h
×
ng/ml)/(dose (mg)/weight (kg)) at baseline.
C
max
1 month post-surgery showed lower values than the control group (375.4 ± 77.4 vs 263.5 ± 52.1 ng/ml;
p
< 0.001).
Conclusion
Ciprofloxacin absorption is impaired 1 month and 6 months after RYGS. The effect on
C
max
and AUClast faded on the sixth month due to weight loss. It is no necessary to modify the doses of ciprofloxacin in these patients.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/s00228-018-02623-8</identifier><identifier>PMID: 30649602</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Antibiotics ; Biomedical and Life Sciences ; Biomedicine ; Body weight ; Body weight loss ; Ciprofloxacin ; Obesity ; Overweight ; Pharmacodynamics ; Pharmacokinetics ; Pharmacology/Toxicology ; Surgery ; Variance analysis ; Weight loss</subject><ispartof>European journal of clinical pharmacology, 2019-05, Vol.75 (5), p.647-654</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>European Journal of Clinical Pharmacology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-84137dcc367393798a22139f235a8be8e9c6bd7a36eeafcecca03d764fbe40253</citedby><cites>FETCH-LOGICAL-c375t-84137dcc367393798a22139f235a8be8e9c6bd7a36eeafcecca03d764fbe40253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00228-018-02623-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00228-018-02623-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30649602$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rivas, Ana Belén</creatorcontrib><creatorcontrib>Lopez-Picado, Amanda</creatorcontrib><creatorcontrib>Salas-Butrón, María del Rosario</creatorcontrib><creatorcontrib>Terleira, Ana</creatorcontrib><creatorcontrib>Sanchez Pernaute, Andres</creatorcontrib><creatorcontrib>Torres Garcia, Antonio José</creatorcontrib><creatorcontrib>Moreno Lopera, Carmen</creatorcontrib><creatorcontrib>Chicharro, Luis Miguel</creatorcontrib><creatorcontrib>Bandrés, Fernando</creatorcontrib><creatorcontrib>Rubio Herrera, Miguel Angel</creatorcontrib><creatorcontrib>Portolés, Antonio</creatorcontrib><creatorcontrib>Vargas, Emilio</creatorcontrib><title>Effect of Roux-en-Y gastric surgery on ciprofloxacin pharmacokinetics: an obvious effect?</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><addtitle>Eur J Clin Pharmacol</addtitle><description>Purpose
To evaluate pharmacokinetic parameters of ciprofloxacin in patients undergoing Roux-en-Y gastric surgery (RYGS).
Methods
Controlled, single-dose, open-label study in patients undergoing RYGS. Healthy overweight/obese patients 18–60 years old were included. The assessment was performed once in control patients and three times in case patients (before surgery and 1 and 6 months after surgery). In each visit, the subjects received a single oral dose of ciprofloxacin 500 mg. Venous blood samples were obtained at baseline and 0.5, 1, 1.25, 1.5, 1.75, 2, 2.5, 3, 4, 8 and 14 h after ciprofloxacin intake. Pre- and post-surgery variables were compared using paired ANOVA or the Wilcoxon tests and control vs cases using ANOVA or Mann Whitney. Given the post-surgery change in body weight, the parameters were corrected by dose (mg)/body weight (kg). The analysis was performed using SPSS.
Results
Ciprofloxacin
C
max
was significantly reduced 1 month after surgery (1840.9 ± 485.2 vs 1589.6 ± 321.8 ng/ml;
p
= 0.032) but not 6 months after.
C
max
on the sixth month was lower than
C
max
in control group (2160.4 ± 408.6 vs 1589.6 ± 321.8 ng/ml;
p
< 0.001). After correcting by the dose (mg)/patient’s body weight, both
C
max
and AUClast showed significant decrease 1 and 6 months after surgery:
C
max
, 289.1 ± 65.3 and 263.5 ± 52.1 (ng/ml)/(dose (mg)/weight (kg)) respectively vs 429.3 ± 127.6 (ng/ml)/(dose (mg)/weight (kg)) at baseline; AUC, 1340.6 ± 243.0 and 1299.2 ± 415.4 (h
×
ng/ml)/(dose (mg)/weight (kg)) respectively vs 1896.7 ± 396.8 (h
×
ng/ml)/(dose (mg)/weight (kg)) at baseline.
C
max
1 month post-surgery showed lower values than the control group (375.4 ± 77.4 vs 263.5 ± 52.1 ng/ml;
p
< 0.001).
Conclusion
Ciprofloxacin absorption is impaired 1 month and 6 months after RYGS. The effect on
C
max
and AUClast faded on the sixth month due to weight loss. It is no necessary to modify the doses of ciprofloxacin in these patients.</description><subject>Antibiotics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Body weight</subject><subject>Body weight loss</subject><subject>Ciprofloxacin</subject><subject>Obesity</subject><subject>Overweight</subject><subject>Pharmacodynamics</subject><subject>Pharmacokinetics</subject><subject>Pharmacology/Toxicology</subject><subject>Surgery</subject><subject>Variance analysis</subject><subject>Weight loss</subject><issn>0031-6970</issn><issn>1432-1041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kEtLxDAQx4Mo7vr4Ah4k4Dk6ybRJ60Vk8QWCIHrwFNJsotXdZk1aWb-90fVx8zDMYf6P4UfIHodDDqCOEoAQFQOeR0iBrFojY16gYBwKvk7GAMiZrBWMyFZKzwC8rAE3yQhBFrUEMSYPZ94729Pg6W0Ylsx17IE-mtTH1tI0xEcX32noqG0XMfhZWBrbdnTxZOLc2PDSdq5vbTqmpqOheWvDkKj7SjzZIRvezJLb_d7b5P787G5yya5vLq4mp9fMoip7VhUc1dRalAprVHVlhOBYe4GlqRpXudrKZqoMSueMt85aAzhVsvCNK0CUuE0OVrn5wdfBpV4_hyF2uVILLlUpJEeRVWKlsjGkFJ3Xi9jOTXzXHPQnTb2iqTNN_UVTV9m0_x09NHM3_bX84MsCXAlSPnWZ1V_3P7EfecJ__w</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Rivas, Ana Belén</creator><creator>Lopez-Picado, Amanda</creator><creator>Salas-Butrón, María del Rosario</creator><creator>Terleira, Ana</creator><creator>Sanchez Pernaute, Andres</creator><creator>Torres Garcia, Antonio José</creator><creator>Moreno Lopera, Carmen</creator><creator>Chicharro, Luis Miguel</creator><creator>Bandrés, Fernando</creator><creator>Rubio Herrera, Miguel Angel</creator><creator>Portolés, Antonio</creator><creator>Vargas, Emilio</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20190501</creationdate><title>Effect of Roux-en-Y gastric surgery on ciprofloxacin pharmacokinetics: an obvious effect?</title><author>Rivas, Ana Belén ; Lopez-Picado, Amanda ; Salas-Butrón, María del Rosario ; Terleira, Ana ; Sanchez Pernaute, Andres ; Torres Garcia, Antonio José ; Moreno Lopera, Carmen ; Chicharro, Luis Miguel ; Bandrés, Fernando ; Rubio Herrera, Miguel Angel ; Portolés, Antonio ; Vargas, Emilio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-84137dcc367393798a22139f235a8be8e9c6bd7a36eeafcecca03d764fbe40253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Antibiotics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Body weight</topic><topic>Body weight loss</topic><topic>Ciprofloxacin</topic><topic>Obesity</topic><topic>Overweight</topic><topic>Pharmacodynamics</topic><topic>Pharmacokinetics</topic><topic>Pharmacology/Toxicology</topic><topic>Surgery</topic><topic>Variance analysis</topic><topic>Weight loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rivas, Ana Belén</creatorcontrib><creatorcontrib>Lopez-Picado, Amanda</creatorcontrib><creatorcontrib>Salas-Butrón, María del Rosario</creatorcontrib><creatorcontrib>Terleira, Ana</creatorcontrib><creatorcontrib>Sanchez Pernaute, Andres</creatorcontrib><creatorcontrib>Torres Garcia, Antonio José</creatorcontrib><creatorcontrib>Moreno Lopera, Carmen</creatorcontrib><creatorcontrib>Chicharro, Luis Miguel</creatorcontrib><creatorcontrib>Bandrés, Fernando</creatorcontrib><creatorcontrib>Rubio Herrera, Miguel Angel</creatorcontrib><creatorcontrib>Portolés, Antonio</creatorcontrib><creatorcontrib>Vargas, Emilio</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rivas, Ana Belén</au><au>Lopez-Picado, Amanda</au><au>Salas-Butrón, María del Rosario</au><au>Terleira, Ana</au><au>Sanchez Pernaute, Andres</au><au>Torres Garcia, Antonio José</au><au>Moreno Lopera, Carmen</au><au>Chicharro, Luis Miguel</au><au>Bandrés, Fernando</au><au>Rubio Herrera, Miguel Angel</au><au>Portolés, Antonio</au><au>Vargas, Emilio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Roux-en-Y gastric surgery on ciprofloxacin pharmacokinetics: an obvious effect?</atitle><jtitle>European journal of clinical pharmacology</jtitle><stitle>Eur J Clin Pharmacol</stitle><addtitle>Eur J Clin Pharmacol</addtitle><date>2019-05-01</date><risdate>2019</risdate><volume>75</volume><issue>5</issue><spage>647</spage><epage>654</epage><pages>647-654</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>Purpose
To evaluate pharmacokinetic parameters of ciprofloxacin in patients undergoing Roux-en-Y gastric surgery (RYGS).
Methods
Controlled, single-dose, open-label study in patients undergoing RYGS. Healthy overweight/obese patients 18–60 years old were included. The assessment was performed once in control patients and three times in case patients (before surgery and 1 and 6 months after surgery). In each visit, the subjects received a single oral dose of ciprofloxacin 500 mg. Venous blood samples were obtained at baseline and 0.5, 1, 1.25, 1.5, 1.75, 2, 2.5, 3, 4, 8 and 14 h after ciprofloxacin intake. Pre- and post-surgery variables were compared using paired ANOVA or the Wilcoxon tests and control vs cases using ANOVA or Mann Whitney. Given the post-surgery change in body weight, the parameters were corrected by dose (mg)/body weight (kg). The analysis was performed using SPSS.
Results
Ciprofloxacin
C
max
was significantly reduced 1 month after surgery (1840.9 ± 485.2 vs 1589.6 ± 321.8 ng/ml;
p
= 0.032) but not 6 months after.
C
max
on the sixth month was lower than
C
max
in control group (2160.4 ± 408.6 vs 1589.6 ± 321.8 ng/ml;
p
< 0.001). After correcting by the dose (mg)/patient’s body weight, both
C
max
and AUClast showed significant decrease 1 and 6 months after surgery:
C
max
, 289.1 ± 65.3 and 263.5 ± 52.1 (ng/ml)/(dose (mg)/weight (kg)) respectively vs 429.3 ± 127.6 (ng/ml)/(dose (mg)/weight (kg)) at baseline; AUC, 1340.6 ± 243.0 and 1299.2 ± 415.4 (h
×
ng/ml)/(dose (mg)/weight (kg)) respectively vs 1896.7 ± 396.8 (h
×
ng/ml)/(dose (mg)/weight (kg)) at baseline.
C
max
1 month post-surgery showed lower values than the control group (375.4 ± 77.4 vs 263.5 ± 52.1 ng/ml;
p
< 0.001).
Conclusion
Ciprofloxacin absorption is impaired 1 month and 6 months after RYGS. The effect on
C
max
and AUClast faded on the sixth month due to weight loss. It is no necessary to modify the doses of ciprofloxacin in these patients.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30649602</pmid><doi>10.1007/s00228-018-02623-8</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-6970 |
| ispartof | European journal of clinical pharmacology, 2019-05, Vol.75 (5), p.647-654 |
| issn | 0031-6970 1432-1041 |
| language | eng |
| recordid | cdi_proquest_journals_2167526132 |
| source | SpringerNature Complete Journals |
| subjects | Antibiotics Biomedical and Life Sciences Biomedicine Body weight Body weight loss Ciprofloxacin Obesity Overweight Pharmacodynamics Pharmacokinetics Pharmacology/Toxicology Surgery Variance analysis Weight loss |
| title | Effect of Roux-en-Y gastric surgery on ciprofloxacin pharmacokinetics: an obvious effect? |
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