A synthetic approach to 'click' neoglycoprotein analogues of EPO employing one-pot native chemical ligation and CuAAC chemistry

The clinical significance of batch-wise variability on the pharmacokinetics and potency of commercial erythropoietin (EPO), prepared recombinantly as a heterogeneous mixture of glycoforms, necessitates the development of synthetic strategies to afford homogenous EPO formulations. Herein we present a...

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Veröffentlicht in:	Chemical science (Cambridge) 2019-01, Vol.10 (3), p.815-828
Hauptverfasser:	Lee, D J, Cameron, A J, Wright, T H, Harris, P W R, Brimble, M A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes Cycloaddition Formulations Monosaccharides Oligosaccharides Organic chemistry Peptides Pharmacology
Online-Zugang:	Volltext
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