High-throughput screening of toxic substances by extractive electrospray ionization mass spectrometry and their identification via databank construction
More than 200 toxic substances (including narcotic drugs, psychotropic drugs, organic phosphorus compounds, carbamates, pyrethroids and other pesticides, veterinary drugs, rodenticides, natural toxins, and other drugs) were identified and quantified using an ion-trap mass spectrometer. The advantage...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2019-07, Vol.411 (18), p.4049-4054 |
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| creator | Wang, Shuanglong Li, Faliang Liu, YongZi Zhao, Huian Chen, Huanwen |
| description | More than 200 toxic substances (including narcotic drugs, psychotropic drugs, organic phosphorus compounds, carbamates, pyrethroids and other pesticides, veterinary drugs, rodenticides, natural toxins, and other drugs) were identified and quantified using an ion-trap mass spectrometer. The advantages of this technique—its selectivity, accuracy, precision, utilization of only small amounts of the sample, and short analysis time for a single sample (less than 30s)—render it a rapid and accurate methodology for toxin screening. Subsequently, an extractive electrospray ionization (EESI) mass spectrometry database was established by combining the Xcalibur data processing system with NIST database software. This allowed unknown toxicants in urine and blood samples, stomach contents, and liver samples, as provided by the Jiangxi Provincial Public Security Department, to be analyzed and identified. This EESI methodology and databank has the potential for widespread application to the large-scale analysis of practical samples.
Graphical abstract
ᅟ |
| doi_str_mv | 10.1007/s00216-018-1520-x |
| format | Article |
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Graphical abstract
ᅟ</description><identifier>ISSN: 1618-2642</identifier><identifier>EISSN: 1618-2650</identifier><identifier>DOI: 10.1007/s00216-018-1520-x</identifier><identifier>PMID: 30635664</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analysis ; Analytical Chemistry ; Biochemistry ; Carbamate pesticides ; Carbamates ; Carbamates (tradename) ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Data banks ; Data processing ; Database management systems ; Databases, Factual ; Drugs ; Electrospraying ; Food Science ; Forensic Toxicology ; Gastrointestinal Contents - chemistry ; Hazardous materials ; Hazardous Substances - analysis ; Hazardous Substances - blood ; Hazardous Substances - urine ; High-throughput screening ; High-Throughput Screening Assays - methods ; Humans ; Ionization ; Ions ; Laboratory Medicine ; Limit of Detection ; Liver ; Liver - chemistry ; Mass spectrometry ; Mass spectroscopy ; Monitoring/Environmental Analysis ; New Insights into Analytical Science in China ; Organic phosphorus ; Organophosphorus compounds ; Paper in Forefront ; Pesticides ; Phosphorus ; Phosphorus compounds ; Psychotropic drugs ; Pyrethroids ; Reproducibility of Results ; Rodenticides ; Scientific imaging ; Screening ; Selectivity ; Spectrometry, Mass, Electrospray Ionization - methods ; Spectroscopy ; Stomach ; Toxic substances ; Toxicants ; Toxins ; Urine ; Veterinary medicine</subject><ispartof>Analytical and bioanalytical chemistry, 2019-07, Vol.411 (18), p.4049-4054</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Analytical and Bioanalytical Chemistry is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-5875919b8c95272aa2d49c67933f55389ae247362f1fdbd90f917a5616c6daee3</citedby><cites>FETCH-LOGICAL-c476t-5875919b8c95272aa2d49c67933f55389ae247362f1fdbd90f917a5616c6daee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00216-018-1520-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00216-018-1520-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30635664$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Shuanglong</creatorcontrib><creatorcontrib>Li, Faliang</creatorcontrib><creatorcontrib>Liu, YongZi</creatorcontrib><creatorcontrib>Zhao, Huian</creatorcontrib><creatorcontrib>Chen, Huanwen</creatorcontrib><title>High-throughput screening of toxic substances by extractive electrospray ionization mass spectrometry and their identification via databank construction</title><title>Analytical and bioanalytical chemistry</title><addtitle>Anal Bioanal Chem</addtitle><addtitle>Anal Bioanal Chem</addtitle><description>More than 200 toxic substances (including narcotic drugs, psychotropic drugs, organic phosphorus compounds, carbamates, pyrethroids and other pesticides, veterinary drugs, rodenticides, natural toxins, and other drugs) were identified and quantified using an ion-trap mass spectrometer. The advantages of this technique—its selectivity, accuracy, precision, utilization of only small amounts of the sample, and short analysis time for a single sample (less than 30s)—render it a rapid and accurate methodology for toxin screening. Subsequently, an extractive electrospray ionization (EESI) mass spectrometry database was established by combining the Xcalibur data processing system with NIST database software. This allowed unknown toxicants in urine and blood samples, stomach contents, and liver samples, as provided by the Jiangxi Provincial Public Security Department, to be analyzed and identified. This EESI methodology and databank has the potential for widespread application to the large-scale analysis of practical samples.
Graphical abstract
ᅟ</description><subject>Analysis</subject><subject>Analytical Chemistry</subject><subject>Biochemistry</subject><subject>Carbamate pesticides</subject><subject>Carbamates</subject><subject>Carbamates (tradename)</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Data banks</subject><subject>Data processing</subject><subject>Database management systems</subject><subject>Databases, Factual</subject><subject>Drugs</subject><subject>Electrospraying</subject><subject>Food Science</subject><subject>Forensic Toxicology</subject><subject>Gastrointestinal Contents - chemistry</subject><subject>Hazardous materials</subject><subject>Hazardous Substances - analysis</subject><subject>Hazardous Substances - blood</subject><subject>Hazardous Substances - urine</subject><subject>High-throughput screening</subject><subject>High-Throughput Screening Assays - methods</subject><subject>Humans</subject><subject>Ionization</subject><subject>Ions</subject><subject>Laboratory Medicine</subject><subject>Limit of Detection</subject><subject>Liver</subject><subject>Liver - chemistry</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Monitoring/Environmental Analysis</subject><subject>New Insights into Analytical Science in China</subject><subject>Organic phosphorus</subject><subject>Organophosphorus compounds</subject><subject>Paper in Forefront</subject><subject>Pesticides</subject><subject>Phosphorus</subject><subject>Phosphorus compounds</subject><subject>Psychotropic drugs</subject><subject>Pyrethroids</subject><subject>Reproducibility of Results</subject><subject>Rodenticides</subject><subject>Scientific imaging</subject><subject>Screening</subject><subject>Selectivity</subject><subject>Spectrometry, Mass, Electrospray Ionization - 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screening of toxic substances by extractive electrospray ionization mass spectrometry and their identification via databank construction</title><author>Wang, Shuanglong ; Li, Faliang ; Liu, YongZi ; Zhao, Huian ; Chen, Huanwen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-5875919b8c95272aa2d49c67933f55389ae247362f1fdbd90f917a5616c6daee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Analysis</topic><topic>Analytical Chemistry</topic><topic>Biochemistry</topic><topic>Carbamate pesticides</topic><topic>Carbamates</topic><topic>Carbamates (tradename)</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Data banks</topic><topic>Data processing</topic><topic>Database management systems</topic><topic>Databases, 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Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Analytical and bioanalytical chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Shuanglong</au><au>Li, Faliang</au><au>Liu, YongZi</au><au>Zhao, Huian</au><au>Chen, Huanwen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-throughput screening of toxic substances by extractive electrospray ionization mass spectrometry and their identification via databank construction</atitle><jtitle>Analytical and bioanalytical chemistry</jtitle><stitle>Anal Bioanal Chem</stitle><addtitle>Anal Bioanal Chem</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>411</volume><issue>18</issue><spage>4049</spage><epage>4054</epage><pages>4049-4054</pages><issn>1618-2642</issn><eissn>1618-2650</eissn><abstract>More than 200 toxic substances (including narcotic drugs, psychotropic drugs, organic phosphorus compounds, carbamates, pyrethroids and other pesticides, veterinary drugs, rodenticides, natural toxins, and other drugs) were identified and quantified using an ion-trap mass spectrometer. The advantages of this technique—its selectivity, accuracy, precision, utilization of only small amounts of the sample, and short analysis time for a single sample (less than 30s)—render it a rapid and accurate methodology for toxin screening. Subsequently, an extractive electrospray ionization (EESI) mass spectrometry database was established by combining the Xcalibur data processing system with NIST database software. This allowed unknown toxicants in urine and blood samples, stomach contents, and liver samples, as provided by the Jiangxi Provincial Public Security Department, to be analyzed and identified. This EESI methodology and databank has the potential for widespread application to the large-scale analysis of practical samples.
Graphical abstract
ᅟ</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30635664</pmid><doi>10.1007/s00216-018-1520-x</doi><tpages>6</tpages></addata></record> |
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| subjects | Analysis Analytical Chemistry Biochemistry Carbamate pesticides Carbamates Carbamates (tradename) Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Data banks Data processing Database management systems Databases, Factual Drugs Electrospraying Food Science Forensic Toxicology Gastrointestinal Contents - chemistry Hazardous materials Hazardous Substances - analysis Hazardous Substances - blood Hazardous Substances - urine High-throughput screening High-Throughput Screening Assays - methods Humans Ionization Ions Laboratory Medicine Limit of Detection Liver Liver - chemistry Mass spectrometry Mass spectroscopy Monitoring/Environmental Analysis New Insights into Analytical Science in China Organic phosphorus Organophosphorus compounds Paper in Forefront Pesticides Phosphorus Phosphorus compounds Psychotropic drugs Pyrethroids Reproducibility of Results Rodenticides Scientific imaging Screening Selectivity Spectrometry, Mass, Electrospray Ionization - methods Spectroscopy Stomach Toxic substances Toxicants Toxins Urine Veterinary medicine |
| title | High-throughput screening of toxic substances by extractive electrospray ionization mass spectrometry and their identification via databank construction |
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