BRCA1/BRCA2 germline mutations and chemotherapy-related hematological toxicity in breast cancer patients

Purpose BRCA1 and BRCA2 proteins are central to DNA repair process through homologous recombination. We hypothesize that BRCA1 / BRCA2 mutation carriers may exhibit increased hematological toxicity when receiving genotoxic chemotherapy. Methods We included women with primary breast cancers screened...

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Veröffentlicht in:	Breast cancer research and treatment 2019-04, Vol.174 (3), p.775-783
Hauptverfasser:	Friedlaender, Alex, Vuilleumier, Aurélie, Viassolo, Valeria, Ayme, Aurélie, De Talhouet, Solène, Combes, Jean-Damien, Peron, Julien, Bodmer, Alexandre, Giraud, Sophie, Buisson, Adrien, Bonadona, Valerie, Gauchat-Bouchardy, Isabelle, Tredan, Olivier, Chappuis, Pierre O., Labidi-Galy, S. Intidhar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant chemotherapy Adult Analysis Biotechnology BRCA1 protein BRCA1 Protein - genetics BRCA2 protein BRCA2 Protein - genetics Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Cancer patients Cancer research Cancer treatment Care and treatment Cerebrospinal fluid Chemotherapy Chemotherapy, Adjuvant - adverse effects Cohort Studies Complications and side effects DNA DNA repair Epidemiology Febrile Neutropenia - chemically induced Febrile Neutropenia - epidemiology Female France Gene mutation Genetic aspects Genotoxicity Germ-Line Mutation Granulocyte colony-stimulating factor Granulocyte Colony-Stimulating Factor - administration & dosage Hematology Homologous recombination Hospitalization - statistics & numerical data Humans Medical research Medicine Medicine & Public Health Middle Aged Mutation Neuropathy Neutropenia Oncology Prophylaxis Proteins Switzerland Toxicity
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