Molecular analysis of the [beta]-catenin gene in patients with the Mayer-Rokitansky-Küster-Hauser syndrome

To study the β-catenin gene in a group of Mayer-Rokitansky-Küster-Hauser patients. Twelve patients with the Mayer-Rokitansky-Küster-Hauser syndrome were included in this study. DNA was extracted from peripheral blood and the region codifying β-catenin GSK-3β phosphorylation sites on exon 3 was amplified. PCR products were purified and directly sequenced. No mutations were found in the GSK-3β phosphorylation sites on exon 3 of β-catenin gene in this group of patients with the MRKH syndrome. β-catenin gene mutations are an unlikely cause of the MRKH syndrome. [PUBLICATION ABSTRACT]