Ropivacaine myotoxicity after single intramuscular injection in rats

Summary Background and objective: We conducted this study in order to evaluate the potential myotoxic effects of ropivacaine after single injection in rats and the time-course of the possible damage. Methods: One hundred and twenty-eight male Wistar rats were allocated to four different groups. The...

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Veröffentlicht in:	European journal of anaesthesiology 2006-02, Vol.23 (2), p.130-135
Hauptverfasser:	Amaniti, E., Drampa, F., Kouzi-Koliakos, K., Kapoukranidou, D., Pourzitaki, C., Tsalie, E., Vasilakos, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - administration & dosage Amides - toxicity Anesthetics, Local - administration & dosage Anesthetics, Local - toxicity Animals Aqueous solutions Clinical medicine Dose-Response Relationship, Drug Hindlimb Histology Injections Injections, Intramuscular Laboratory animals Male Microscopy, Electron, Transmission Muscle, Skeletal - drug effects Muscle, Skeletal - pathology Muscle, Skeletal - ultrastructure Muscular system Necrosis Original Article Rats Rats, Wistar Rodents Studies Tissues
Online-Zugang:	Volltext
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