Long-term follow-up after combined fissurectomy and Botox injection for chronic anal fissures
Chronic anal fissures are difficult to treat. The aim of this retrospective study was to determine the outcome of combined fissurectomy and injection of botulinum toxin Type A (BT). Between January 2001 and August 2004, 40 patients (21 women), median age 37 years (range 18 to 57), underwent fissurec...
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| Veröffentlicht in: | International journal of colorectal disease 2007-09, Vol.22 (9), p.1077-1081 |
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| container_title | International journal of colorectal disease |
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| creator | SCHOLZ, Th HETZER, F. H DINDO, D DEMARTINES, N CLAVIEN, P. A HAHNLOSER, D |
| description | Chronic anal fissures are difficult to treat. The aim of this retrospective study was to determine the outcome of combined fissurectomy and injection of botulinum toxin Type A (BT).
Between January 2001 and August 2004, 40 patients (21 women), median age 37 years (range 18 to 57), underwent fissurectomy and BT injection. Fissurectomy was performed followed by injection of 10 U of BT into the internal anal sphincter on both sides of the fissure. All patients were clinically checked 6 weeks after the operation. At 1 year, patients were sent a detailed questionnaire regarding symptoms, recurrence and further treatment for evaluation of long-term results.
At 6 weeks, 38 patients (95%) were free of symptoms. No adverse effects were detected. The response rate of questionnaires was 93%; the median follow-up was 1 year (range 0.9 to 1.6). In the long-term, a recurrence was found in four patients. These patients were treated successfully with repeated fissurectomy and BT injections and salvage procedures, respectively. Overall, the success rate of combined fissurectomy and BT injection was 79%.
Combined fissurectomy and Botox injection for chronic anal fissure is an excellent and safe procedure with low morbidity and a high healing rate. |
| doi_str_mv | 10.1007/s00384-006-0261-z |
| format | Article |
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Between January 2001 and August 2004, 40 patients (21 women), median age 37 years (range 18 to 57), underwent fissurectomy and BT injection. Fissurectomy was performed followed by injection of 10 U of BT into the internal anal sphincter on both sides of the fissure. All patients were clinically checked 6 weeks after the operation. At 1 year, patients were sent a detailed questionnaire regarding symptoms, recurrence and further treatment for evaluation of long-term results.
At 6 weeks, 38 patients (95%) were free of symptoms. No adverse effects were detected. The response rate of questionnaires was 93%; the median follow-up was 1 year (range 0.9 to 1.6). In the long-term, a recurrence was found in four patients. These patients were treated successfully with repeated fissurectomy and BT injections and salvage procedures, respectively. Overall, the success rate of combined fissurectomy and BT injection was 79%.
Combined fissurectomy and Botox injection for chronic anal fissure is an excellent and safe procedure with low morbidity and a high healing rate.</description><identifier>ISSN: 0179-1958</identifier><identifier>EISSN: 1432-1262</identifier><identifier>DOI: 10.1007/s00384-006-0261-z</identifier><identifier>PMID: 17262202</identifier><identifier>CODEN: IJCDE6</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Botulinum Toxins, Type A - adverse effects ; Botulinum Toxins, Type A - therapeutic use ; Chronic Disease ; Drug Therapy, Combination ; Female ; Fissure in Ano - drug therapy ; Fissure in Ano - surgery ; Follow-Up Studies ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Male ; Medical sciences ; Middle Aged ; Neuromuscular Agents - therapeutic use ; Other diseases. Semiology ; Retrospective Studies ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Treatment Outcome ; Wound Healing - drug effects</subject><ispartof>International journal of colorectal disease, 2007-09, Vol.22 (9), p.1077-1081</ispartof><rights>2007 INIST-CNRS</rights><rights>Springer-Verlag 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-c73967ba138010a4e866d9466d78769e1b55df1196985b6888b78ea1aeae60183</citedby><cites>FETCH-LOGICAL-c399t-c73967ba138010a4e866d9466d78769e1b55df1196985b6888b78ea1aeae60183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18941007$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17262202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SCHOLZ, Th</creatorcontrib><creatorcontrib>HETZER, F. H</creatorcontrib><creatorcontrib>DINDO, D</creatorcontrib><creatorcontrib>DEMARTINES, N</creatorcontrib><creatorcontrib>CLAVIEN, P. A</creatorcontrib><creatorcontrib>HAHNLOSER, D</creatorcontrib><title>Long-term follow-up after combined fissurectomy and Botox injection for chronic anal fissures</title><title>International journal of colorectal disease</title><addtitle>Int J Colorectal Dis</addtitle><description>Chronic anal fissures are difficult to treat. The aim of this retrospective study was to determine the outcome of combined fissurectomy and injection of botulinum toxin Type A (BT).
Between January 2001 and August 2004, 40 patients (21 women), median age 37 years (range 18 to 57), underwent fissurectomy and BT injection. Fissurectomy was performed followed by injection of 10 U of BT into the internal anal sphincter on both sides of the fissure. All patients were clinically checked 6 weeks after the operation. At 1 year, patients were sent a detailed questionnaire regarding symptoms, recurrence and further treatment for evaluation of long-term results.
At 6 weeks, 38 patients (95%) were free of symptoms. No adverse effects were detected. The response rate of questionnaires was 93%; the median follow-up was 1 year (range 0.9 to 1.6). In the long-term, a recurrence was found in four patients. These patients were treated successfully with repeated fissurectomy and BT injections and salvage procedures, respectively. Overall, the success rate of combined fissurectomy and BT injection was 79%.
Combined fissurectomy and Botox injection for chronic anal fissure is an excellent and safe procedure with low morbidity and a high healing rate.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Botulinum Toxins, Type A - adverse effects</subject><subject>Botulinum Toxins, Type A - therapeutic use</subject><subject>Chronic Disease</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Fissure in Ano - drug therapy</subject><subject>Fissure in Ano - surgery</subject><subject>Follow-Up Studies</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuromuscular Agents - therapeutic use</subject><subject>Other diseases. Semiology</subject><subject>Retrospective Studies</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Treatment Outcome</subject><subject>Wound Healing - drug effects</subject><issn>0179-1958</issn><issn>1432-1262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpFkMtKAzEUhoMotlYfwI0MgsvoOXPJZanFGxTc6FJCJpPRKTOTmsyg7dOb0oqbhJx8_0_yEXKOcI0A_CYAZCKnAIxCypBuDsgU8yylmLL0kEwBuaQoCzEhJyEsIZ4Zz4_JBHkEUkin5H3h-g86WN8ltWtb903HVaLrOEiM68qmt1VSNyGM3prBdetE91Vy5wb3kzT9Ms4a18dkpD-96xsT73X7lwin5KjWbbBn-31G3h7uX-dPdPHy-Dy_XVCTSTlQwzPJeKkxE4CgcysYq2QeFy44kxbLoqhqRMmkKEomhCi5sBq11ZYBimxGLne9K---RhsGtXSjjy8JKkVWxM8KiBDuIONdCN7WauWbTvu1QlBbn2rnU0WfautTbWLmYl88lp2t_hN7gRG42gM6GN3WXvemCf-ckPm2OvsF_cl9kQ</recordid><startdate>20070901</startdate><enddate>20070901</enddate><creator>SCHOLZ, Th</creator><creator>HETZER, F. 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H ; DINDO, D ; DEMARTINES, N ; CLAVIEN, P. A ; HAHNLOSER, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-c73967ba138010a4e866d9466d78769e1b55df1196985b6888b78ea1aeae60183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Botulinum Toxins, Type A - adverse effects</topic><topic>Botulinum Toxins, Type A - therapeutic use</topic><topic>Chronic Disease</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Fissure in Ano - drug therapy</topic><topic>Fissure in Ano - surgery</topic><topic>Follow-Up Studies</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neuromuscular Agents - therapeutic use</topic><topic>Other diseases. Semiology</topic><topic>Retrospective Studies</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Treatment Outcome</topic><topic>Wound Healing - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SCHOLZ, Th</creatorcontrib><creatorcontrib>HETZER, F. H</creatorcontrib><creatorcontrib>DINDO, D</creatorcontrib><creatorcontrib>DEMARTINES, N</creatorcontrib><creatorcontrib>CLAVIEN, P. 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H</au><au>DINDO, D</au><au>DEMARTINES, N</au><au>CLAVIEN, P. A</au><au>HAHNLOSER, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term follow-up after combined fissurectomy and Botox injection for chronic anal fissures</atitle><jtitle>International journal of colorectal disease</jtitle><addtitle>Int J Colorectal Dis</addtitle><date>2007-09-01</date><risdate>2007</risdate><volume>22</volume><issue>9</issue><spage>1077</spage><epage>1081</epage><pages>1077-1081</pages><issn>0179-1958</issn><eissn>1432-1262</eissn><coden>IJCDE6</coden><abstract>Chronic anal fissures are difficult to treat. The aim of this retrospective study was to determine the outcome of combined fissurectomy and injection of botulinum toxin Type A (BT).
Between January 2001 and August 2004, 40 patients (21 women), median age 37 years (range 18 to 57), underwent fissurectomy and BT injection. Fissurectomy was performed followed by injection of 10 U of BT into the internal anal sphincter on both sides of the fissure. All patients were clinically checked 6 weeks after the operation. At 1 year, patients were sent a detailed questionnaire regarding symptoms, recurrence and further treatment for evaluation of long-term results.
At 6 weeks, 38 patients (95%) were free of symptoms. No adverse effects were detected. The response rate of questionnaires was 93%; the median follow-up was 1 year (range 0.9 to 1.6). In the long-term, a recurrence was found in four patients. These patients were treated successfully with repeated fissurectomy and BT injections and salvage procedures, respectively. Overall, the success rate of combined fissurectomy and BT injection was 79%.
Combined fissurectomy and Botox injection for chronic anal fissure is an excellent and safe procedure with low morbidity and a high healing rate.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>17262202</pmid><doi>10.1007/s00384-006-0261-z</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of colorectal disease, 2007-09, Vol.22 (9), p.1077-1081 |
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| subjects | Adolescent Adult Biological and medical sciences Botulinum Toxins, Type A - adverse effects Botulinum Toxins, Type A - therapeutic use Chronic Disease Drug Therapy, Combination Female Fissure in Ano - drug therapy Fissure in Ano - surgery Follow-Up Studies Gastroenterology. Liver. Pancreas. Abdomen Humans Male Medical sciences Middle Aged Neuromuscular Agents - therapeutic use Other diseases. Semiology Retrospective Studies Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Treatment Outcome Wound Healing - drug effects |
| title | Long-term follow-up after combined fissurectomy and Botox injection for chronic anal fissures |
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