A phase II study of 9-nitro-camptothecin in patients with previously treated metastatic breast cancer

This Phase II study was conducted to determine the efficacy and toxicity of 9-nitro-camptothecin (9-NC) in patients with previously treated metastatic breast cancer. Pharmacokinetic samples were obtained to investigate the correlation of plasma 9-NC exposure with clinical response and toxicity. Elig...

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Veröffentlicht in:	Investigational new drugs 2004-01, Vol.22 (1), p.69-73
Hauptverfasser:	Miller, Kathy D, Soule, Sharon E, Haney, LaTrice G, Guiney, Patricia, Murry, Darryl J, Lenaz, Luigi, Sun, Show-Li, Sledge, Jr, George W
Format:	Artikel
Sprache:	eng
Schlagworte:	Alopecia Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - therapeutic use Area Under Curve Baldness Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - pathology Camptothecin - analogs & derivatives Camptothecin - pharmacokinetics Camptothecin - therapeutic use Cancer therapies Chemotherapy Diarrhea Drug dosages Enrollments Female Humans Hypotheses Metabolic Clearance Rate Metastasis Middle Aged Nausea Neoplasm Metastasis Patients Pharmacokinetics Plasma Response rates Toxicity Vomiting Womens health
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