Activity of weekly irinotecan (CPT-11) in patients with advanced non-small cell lung cancer pretreated with platinum and taxanes

Irinotecan (CPT-11), a semisynthetic derivative of camptothecin, is active in the treatment of non-small cell lung cancer (NSCLC). In this report we describe our experience with this drug when used as a single agent in patients with advanced NSCLC refractory to chemotherapy with platinum and taxanes...

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Veröffentlicht in:	Investigational new drugs 2003-11, Vol.21 (4), p.459-463
Hauptverfasser:	SANCHEZ, Rosa, ESTEBAN, Emilio, MAREQUE, Beatriz, ESTRADA, Enrique, BUESA, Jose M, LACAVE, Angel J, PALACIO, Isabel, FERNANDEZ, Yolanda, MUNIZ, Isabel, VIEITEZ, Jose M, FRA, Joaquin, BLAY, Pilar, VILLANUEVA, Noemi, UNA, Esther
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic agents Biological and medical sciences Camptothecin - administration & dosage Camptothecin - adverse effects Camptothecin - analogs & derivatives Cancer therapies Carcinoma, Non-Small-Cell Lung - blood Carcinoma, Non-Small-Cell Lung - drug therapy Chemotherapy Confidence Intervals Cytotoxicity Diarrhea Drug Administration Schedule Drug dosages Drug withdrawal Female Granulocytes Hematologic Diseases - blood Hematologic Diseases - chemically induced Hematology Humans Karnofsky Performance Status - statistics & numerical data Lung cancer Lung diseases Lung Neoplasms - blood Lung Neoplasms - drug therapy Male Medical sciences Middle Aged Neutropenia Patients Pharmacology. Drug treatments Platinum - therapeutic use Prospective Studies Response rates Squamous cell carcinoma Taxoids - therapeutic use Thrombocytopenia Toxicity
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