Gemcitabine plus dose-escalated epirubicin in advanced breast cancer : results of a phase I study

Gemcitabine has shown single-agent activity in metastatic breast cancer. Epirubicin is also widely used for the adjuvant and treatment of metastatic breast cancer. The toxicity profiles and modes of action are different which provides a good rationale for studying both drugs in combination. In a pha...

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Veröffentlicht in:	Investigational new drugs 1998-01, Vol.16 (2), p.141-146
Hauptverfasser:	LÜFTNER, D, FLATH, B, AKRIVAKIS, C, MERGENTHALER, H.-G, OHNMACHT, U, ARNING, M, POSSINGER, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Adult Aged Alopecia Antimetabolites, Antineoplastic - therapeutic use Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - therapeutic use Baldness Biological and medical sciences Blood Cells - drug effects Breast cancer Breast Neoplasms - drug therapy Cancer therapies Chemotherapy Deoxycytidine - administration & dosage Deoxycytidine - adverse effects Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use Dose-Response Relationship, Drug Drug dosages Epirubicin - administration & dosage Epirubicin - therapeutic use Female Hematology Humans Injections, Intravenous Medical sciences Metastasis Middle Aged Nausea Neoplasm Staging Neutropenia Patients Pharmacology. Drug treatments Radiation Response rates Thrombocytopenia Toxicity Vomiting
Online-Zugang:	Volltext
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