Preclinical antitumor activity of XK469 (NSC 656889)

XK469 (NSC 656889) is a water-soluble member of the novel quinoxaline family of antitumor agents. In vitro, XK469 demonstrated selective cytotoxicity for several murine solid tumors including colorectal and mammary adenocarcinoma cell lines, when compared to both leukemia and normal epithelial cells...

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Veröffentlicht in:	Investigational new drugs 1998, Vol.16 (4), p.287-296
Hauptverfasser:	LORUSSO, P. M, PARCHMENT, R, DEMCHIK, L, KNIGHT, J, POLIN, L, DZUBOW, J, BEHRENS, C, HARRISON, B, TRAINOR, G, CORBETT, T. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - pharmacology Antineoplastic Agents - toxicity Biological and medical sciences Bone marrow Bone Marrow Cells - drug effects Cancer Cancer therapies Cell Division - drug effects Chemotherapy Cytotoxicity Drug dosages Drug Screening Assays, Antitumor Females Granulocytes Humans Leukemia Medical sciences Mice Mice, SCID Neutrophils Pharmacology. Drug treatments Quinoxalines - pharmacology Quinoxalines - toxicity Toxicity Tumor Cells, Cultured Tumors
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