Preparation of Liquid Crystalline Molecularly Imprinted Polymer Coated Metal Organic Framework for Capecitabine Delivery
A novel molecularly imprinted polymer (MIP) coated metal organic framework (MOF) containing a liquid crystalline (LC) monomer is successfully synthesized for use in drug delivery systems. In this study, [Cu3(BTC)2(H2O)3] n (HKUST‐1) is chosen as the MOF support owing to its large pore volume, good d...
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| Veröffentlicht in: | Particle & particle systems characterization 2019-01, Vol.36 (1), p.n/a |
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| creator | Zhang, Li‐Ping Mo, Chun‐E Huang, Yan‐Ping Liu, Zhao‐Sheng |
| description | A novel molecularly imprinted polymer (MIP) coated metal organic framework (MOF) containing a liquid crystalline (LC) monomer is successfully synthesized for use in drug delivery systems. In this study, [Cu3(BTC)2(H2O)3]
n
(HKUST‐1) is chosen as the MOF support owing to its large pore volume, good diffusion, and thermostability. 4‐Methyl phenyl dicyclohexyl ethylene (MPDE) is used as a LC monomer to increase the solvent‐responsive floating of the composite. The preparation conditions of HKUST‐1@LC‐MIP with capecitabine (CAPE) as a template, including the types of functional monomer, the ratio between template and functional monomer, as well as the content of MPDE, are investigated. Characterizations of the HKUST‐1@LC‐MIP are explored using scanning electron microscopy and transmission electron microscope images, Fourier transform infrared spectroscopy, thermal gravimetric analysis, X‐ray diffraction, and nitrogen adsorption. Compared to the HKUST‐1, the HKUST‐1@LC‐MIP shows better stability in aqueous solution. In vitro release studies of CAPE of HKUST‐1@LC‐MIP show zero‐order release of profiles at the loaded concentration of 500 µg mL−1. From in vivo pharmacokinetic studies, the HKUST‐1@LC‐MIP displays higher relative bioavailability. It turns out that the HKUST‐1@LC‐MIP possesses the properties of controlled release and has the potentials for oral administration.
A novel molecularly imprinted polymer (MIP) coated with metal organic framework containing liquid crystalline (LC) monomer is synthesized for use in drug delivery systems. Compared to HKUST‐1, the HKUST‐1@LC‐MIP shows better stability in aqueous solution. In vitro and in vivo pharmacokinetic studies demonstrate that the HKUST‐1@LC‐MIP possesses the properties of controlled release and has the potentials for oral administration. |
| doi_str_mv | 10.1002/ppsc.201800355 |
| format | Article |
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n
(HKUST‐1) is chosen as the MOF support owing to its large pore volume, good diffusion, and thermostability. 4‐Methyl phenyl dicyclohexyl ethylene (MPDE) is used as a LC monomer to increase the solvent‐responsive floating of the composite. The preparation conditions of HKUST‐1@LC‐MIP with capecitabine (CAPE) as a template, including the types of functional monomer, the ratio between template and functional monomer, as well as the content of MPDE, are investigated. Characterizations of the HKUST‐1@LC‐MIP are explored using scanning electron microscopy and transmission electron microscope images, Fourier transform infrared spectroscopy, thermal gravimetric analysis, X‐ray diffraction, and nitrogen adsorption. Compared to the HKUST‐1, the HKUST‐1@LC‐MIP shows better stability in aqueous solution. In vitro release studies of CAPE of HKUST‐1@LC‐MIP show zero‐order release of profiles at the loaded concentration of 500 µg mL−1. From in vivo pharmacokinetic studies, the HKUST‐1@LC‐MIP displays higher relative bioavailability. It turns out that the HKUST‐1@LC‐MIP possesses the properties of controlled release and has the potentials for oral administration.
A novel molecularly imprinted polymer (MIP) coated with metal organic framework containing liquid crystalline (LC) monomer is synthesized for use in drug delivery systems. Compared to HKUST‐1, the HKUST‐1@LC‐MIP shows better stability in aqueous solution. In vitro and in vivo pharmacokinetic studies demonstrate that the HKUST‐1@LC‐MIP possesses the properties of controlled release and has the potentials for oral administration.</description><identifier>ISSN: 0934-0866</identifier><identifier>EISSN: 1521-4117</identifier><identifier>DOI: 10.1002/ppsc.201800355</identifier><language>eng</language><publisher>Weinheim: Wiley Subscription Services, Inc</publisher><subject>Aqueous solutions ; Bioavailability ; capecitabine ; Controlled release ; Crystal structure ; Crystallinity ; drug delivery ; Drug delivery systems ; Electron microscopes ; Fourier transforms ; Gravimetric analysis ; HKUST‐1 ; Image transmission ; In vivo methods and tests ; Infrared analysis ; Infrared imagery ; liquid crystal monomer ; Liquid crystals ; Metal-organic frameworks ; molecularly imprinted polymer ; Monomers ; Pharmacology ; Polymer coatings ; Polymers ; Scanning electron microscopy ; Thermal stability ; X-ray diffraction</subject><ispartof>Particle & particle systems characterization, 2019-01, Vol.36 (1), p.n/a</ispartof><rights>2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3945-e6c4a4a35b689b8e4990f92d165343f3a4bf6f4b0a1f3d04a798f94e7fbd48643</citedby><cites>FETCH-LOGICAL-c3945-e6c4a4a35b689b8e4990f92d165343f3a4bf6f4b0a1f3d04a798f94e7fbd48643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fppsc.201800355$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fppsc.201800355$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids></links><search><creatorcontrib>Zhang, Li‐Ping</creatorcontrib><creatorcontrib>Mo, Chun‐E</creatorcontrib><creatorcontrib>Huang, Yan‐Ping</creatorcontrib><creatorcontrib>Liu, Zhao‐Sheng</creatorcontrib><title>Preparation of Liquid Crystalline Molecularly Imprinted Polymer Coated Metal Organic Framework for Capecitabine Delivery</title><title>Particle & particle systems characterization</title><description>A novel molecularly imprinted polymer (MIP) coated metal organic framework (MOF) containing a liquid crystalline (LC) monomer is successfully synthesized for use in drug delivery systems. In this study, [Cu3(BTC)2(H2O)3]
n
(HKUST‐1) is chosen as the MOF support owing to its large pore volume, good diffusion, and thermostability. 4‐Methyl phenyl dicyclohexyl ethylene (MPDE) is used as a LC monomer to increase the solvent‐responsive floating of the composite. The preparation conditions of HKUST‐1@LC‐MIP with capecitabine (CAPE) as a template, including the types of functional monomer, the ratio between template and functional monomer, as well as the content of MPDE, are investigated. Characterizations of the HKUST‐1@LC‐MIP are explored using scanning electron microscopy and transmission electron microscope images, Fourier transform infrared spectroscopy, thermal gravimetric analysis, X‐ray diffraction, and nitrogen adsorption. Compared to the HKUST‐1, the HKUST‐1@LC‐MIP shows better stability in aqueous solution. In vitro release studies of CAPE of HKUST‐1@LC‐MIP show zero‐order release of profiles at the loaded concentration of 500 µg mL−1. From in vivo pharmacokinetic studies, the HKUST‐1@LC‐MIP displays higher relative bioavailability. It turns out that the HKUST‐1@LC‐MIP possesses the properties of controlled release and has the potentials for oral administration.
A novel molecularly imprinted polymer (MIP) coated with metal organic framework containing liquid crystalline (LC) monomer is synthesized for use in drug delivery systems. Compared to HKUST‐1, the HKUST‐1@LC‐MIP shows better stability in aqueous solution. In vitro and in vivo pharmacokinetic studies demonstrate that the HKUST‐1@LC‐MIP possesses the properties of controlled release and has the potentials for oral administration.</description><subject>Aqueous solutions</subject><subject>Bioavailability</subject><subject>capecitabine</subject><subject>Controlled release</subject><subject>Crystal structure</subject><subject>Crystallinity</subject><subject>drug delivery</subject><subject>Drug delivery systems</subject><subject>Electron microscopes</subject><subject>Fourier transforms</subject><subject>Gravimetric analysis</subject><subject>HKUST‐1</subject><subject>Image transmission</subject><subject>In vivo methods and tests</subject><subject>Infrared analysis</subject><subject>Infrared imagery</subject><subject>liquid crystal monomer</subject><subject>Liquid crystals</subject><subject>Metal-organic frameworks</subject><subject>molecularly imprinted polymer</subject><subject>Monomers</subject><subject>Pharmacology</subject><subject>Polymer coatings</subject><subject>Polymers</subject><subject>Scanning electron microscopy</subject><subject>Thermal stability</subject><subject>X-ray diffraction</subject><issn>0934-0866</issn><issn>1521-4117</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkMFLwzAUh4MoOKdXzwHPnUmTZs1RqtPBZAX1XNL2RTLTpktbZ_97WyZ69PR48H2_x_shdE3JghIS3jZNWyxCQmNCWBSdoBmNQhpwSpenaEYk4wGJhThHF227I4SIiIoZ-ko9NMqrzrgaO403Zt-bEid-aDtlrakBPzsLRW-VtwNeV403dQclTp0dKvA4cWpan2HE8da_q9oUeOVVBQfnP7B2I6IaKEyn8intHqz5BD9cojOtbAtXP3OO3lYPr8lTsNk-rpO7TVAwyaMARMEVVyzKRSzzGLiURMuwpCJinGmmeK6F5jlRVLOScLWUsZYcljoveSw4m6ObY27j3b6Htst2rvf1eDILqZjiQjJRiyNVeNe2HnQ2_lkpP2SUZFO72dRu9tvuKMijcDAWhn_oLE1fkj_3G22AgHA</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Zhang, Li‐Ping</creator><creator>Mo, Chun‐E</creator><creator>Huang, Yan‐Ping</creator><creator>Liu, Zhao‐Sheng</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>201901</creationdate><title>Preparation of Liquid Crystalline Molecularly Imprinted Polymer Coated Metal Organic Framework for Capecitabine Delivery</title><author>Zhang, Li‐Ping ; Mo, Chun‐E ; Huang, Yan‐Ping ; Liu, Zhao‐Sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3945-e6c4a4a35b689b8e4990f92d165343f3a4bf6f4b0a1f3d04a798f94e7fbd48643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aqueous solutions</topic><topic>Bioavailability</topic><topic>capecitabine</topic><topic>Controlled release</topic><topic>Crystal structure</topic><topic>Crystallinity</topic><topic>drug delivery</topic><topic>Drug delivery systems</topic><topic>Electron microscopes</topic><topic>Fourier transforms</topic><topic>Gravimetric analysis</topic><topic>HKUST‐1</topic><topic>Image transmission</topic><topic>In vivo methods and tests</topic><topic>Infrared analysis</topic><topic>Infrared imagery</topic><topic>liquid crystal monomer</topic><topic>Liquid crystals</topic><topic>Metal-organic frameworks</topic><topic>molecularly imprinted polymer</topic><topic>Monomers</topic><topic>Pharmacology</topic><topic>Polymer coatings</topic><topic>Polymers</topic><topic>Scanning electron microscopy</topic><topic>Thermal stability</topic><topic>X-ray diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Li‐Ping</creatorcontrib><creatorcontrib>Mo, Chun‐E</creatorcontrib><creatorcontrib>Huang, Yan‐Ping</creatorcontrib><creatorcontrib>Liu, Zhao‐Sheng</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Particle & particle systems characterization</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Li‐Ping</au><au>Mo, Chun‐E</au><au>Huang, Yan‐Ping</au><au>Liu, Zhao‐Sheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation of Liquid Crystalline Molecularly Imprinted Polymer Coated Metal Organic Framework for Capecitabine Delivery</atitle><jtitle>Particle & particle systems characterization</jtitle><date>2019-01</date><risdate>2019</risdate><volume>36</volume><issue>1</issue><epage>n/a</epage><issn>0934-0866</issn><eissn>1521-4117</eissn><abstract>A novel molecularly imprinted polymer (MIP) coated metal organic framework (MOF) containing a liquid crystalline (LC) monomer is successfully synthesized for use in drug delivery systems. In this study, [Cu3(BTC)2(H2O)3]
n
(HKUST‐1) is chosen as the MOF support owing to its large pore volume, good diffusion, and thermostability. 4‐Methyl phenyl dicyclohexyl ethylene (MPDE) is used as a LC monomer to increase the solvent‐responsive floating of the composite. The preparation conditions of HKUST‐1@LC‐MIP with capecitabine (CAPE) as a template, including the types of functional monomer, the ratio between template and functional monomer, as well as the content of MPDE, are investigated. Characterizations of the HKUST‐1@LC‐MIP are explored using scanning electron microscopy and transmission electron microscope images, Fourier transform infrared spectroscopy, thermal gravimetric analysis, X‐ray diffraction, and nitrogen adsorption. Compared to the HKUST‐1, the HKUST‐1@LC‐MIP shows better stability in aqueous solution. In vitro release studies of CAPE of HKUST‐1@LC‐MIP show zero‐order release of profiles at the loaded concentration of 500 µg mL−1. From in vivo pharmacokinetic studies, the HKUST‐1@LC‐MIP displays higher relative bioavailability. It turns out that the HKUST‐1@LC‐MIP possesses the properties of controlled release and has the potentials for oral administration.
A novel molecularly imprinted polymer (MIP) coated with metal organic framework containing liquid crystalline (LC) monomer is synthesized for use in drug delivery systems. Compared to HKUST‐1, the HKUST‐1@LC‐MIP shows better stability in aqueous solution. In vitro and in vivo pharmacokinetic studies demonstrate that the HKUST‐1@LC‐MIP possesses the properties of controlled release and has the potentials for oral administration.</abstract><cop>Weinheim</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/ppsc.201800355</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aqueous solutions Bioavailability capecitabine Controlled release Crystal structure Crystallinity drug delivery Drug delivery systems Electron microscopes Fourier transforms Gravimetric analysis HKUST‐1 Image transmission In vivo methods and tests Infrared analysis Infrared imagery liquid crystal monomer Liquid crystals Metal-organic frameworks molecularly imprinted polymer Monomers Pharmacology Polymer coatings Polymers Scanning electron microscopy Thermal stability X-ray diffraction |
| title | Preparation of Liquid Crystalline Molecularly Imprinted Polymer Coated Metal Organic Framework for Capecitabine Delivery |
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