Loss-of-Function Mutation in Myostatin Reduces Tumor Necrosis Factor [alpha] Production and Protects Liver Against Obesity-Induced Insulin Resistance

Insulin resistance develops in tandem with obesity. Ablating myostatin (Mstn) prevents obesity, so we investigated if Mstn deficiency could improve insulin sensitivity. A loss-of-function mutation (Mstn(Ln)) in either one or both alleles of the Mstn gene shows how Mstn deficiency protects whole-body...

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Veröffentlicht in:Diabetes (New York, N.Y.) N.Y.), 2009-05, Vol.58 (5), p.1133
Hauptverfasser: Wilkes, Jason J, Lloyd, David J, Gekakis, Nick
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Sprache:eng
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