LKB1 and AMPK Family Signaling: The Intimate Link Between Cell Polarity and Energy Metabolism

Hubrecht Institute, Developmental Biology and Stem Cell Research, and Department of Pathology, University Medical Centre, Utrecht; and Department of Pathology, Academic Medical Centre, Amsterdam, The Netherlands Research on the LKB1 tumor suppressor protein mutated in cancer-prone Peutz-Jeghers pati...

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Veröffentlicht in:	Physiological reviews 2009-07, Vol.89 (3), p.777-798
Hauptverfasser:	Jansen, Marnix, ten Klooster, Jean Paul, Offerhaus, G. Johan, Clevers, Hans
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - physiology Animals Biochemistry Cancer Cell Polarity - physiology Cells Disease Models, Animal Energy Metabolism - physiology Humans Medical research Metabolism Mice Patients Peutz-Jeghers Syndrome - genetics Peutz-Jeghers Syndrome - physiopathology Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - physiology Proteins Signal Transduction - physiology Tumors
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