Activation of vascular protein kinase C-[beta] inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance

Activation of protein kinase C (PKC) in vascular tissue is associated with endothelial dysfunction and insulin resistance. However, the effect of vascular PKC activation on insulin-stimulated endothelial nitric oxide (NO) synthase (eNOS) regulation has not been characterized in obesity-associated in...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2006-03, Vol.55 (3), p.691
Hauptverfasser:	Naruse, Keiko, Rask-Madsen, Christian, Takahara, Noriko, Ha, Sung-woo, Suzuma, Kiyoshi, Way, Kerrie J, Jacobs, Judith R.C, Clermont, Allen C, Ueki, Kohjiro, Ohshiro, Yuzuru, Zhang, Junqing, Goldfine, Allison B, King, George L
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioavailability Cell culture Coronary vessels Diabetes Diabetes research Endothelial growth factors Endothelium Gene expression Hyperglycemia Insulin resistance Kinases Laboratories Nitric oxide Obesity Phosphorylation Physiology Protein kinases Proteins Transgenic animals Vascular endothelial growth factor
Online-Zugang:	Volltext
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