Flux through the hexosamine pathway is a determinant of nuclear factor (kappa)beta-dependent promoter activation

The hexosamine pathway may mediate some of the toxic effects of glucose. We hypothesized that flux through this pathway might regulate the activity of nuclear factor kappaB (NF-kappaB)-dependent genes in mesangial cells (MCs). In MCs, RT-PCR revealed that high glucose (30 mmol/l) and glucosamine (1...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2002-04, Vol.51 (4), p.1146
Hauptverfasser:	James, Leighton R, Tang, Damu, Ingram, Alistair, Ly, Hao, Thai, Kerri
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell adhesion & migration Cytokines Diabetes Enzymes Glucose Growth factors Kidney diseases Kinases Proteins Tumor necrosis factor-TNF
Online-Zugang:	Volltext
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