Oxygen tension regulates pancreatic [beta]-cell differentiation through hypoxia-inducible factor 1[alpha].(ORIGINAL ARTICLE)

OBJECTIVE--Recent evidence indicates that low oxygen tension (p[O.sub.2]) or hypoxia controls the differentiation of several cell types during development. Variations of p[O.sub.2] are mediated through the hypoxia-inducible factor (HIF), a crucial mediator of the adaptative response of cells to hypo...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2010-03, Vol.59 (3), p.662
Hauptverfasser:	Heinis, Mylene, Simon, Marie-Therese, Ilc, Karine, Mazure, Nathalie M, Pouyssegur, Jacques, Scharfmann, Raphael, Duvillie, Bertrand
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell differentiation Collagen Genetic aspects Hypoxia Oxidative stress Pancreas Pancreatic beta cells Physiological aspects Stem cells Transcription factors
Online-Zugang:	Volltext
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