Overexpression of Metallothionein in Pancreatic β-Cells Reduces Streptozotocin-Induced DNA Damage and Diabetes

Overexpression of Metallothionein in Pancreatic β-Cells Reduces Streptozotocin-Induced DNA Damage and Diabetes Hainan Chen 1 , Edward C. Carlson 2 , Lori Pellet 3 , Jon T. Moritz 3 and Paul N. Epstein 1 1 Department of Pediatrics, University of Louisville, Louisville, Kentucky 2 Department of Anatom...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2001-09, Vol.50 (9), p.2040-2046
Hauptverfasser:	Chen, H, Carlson, E C, Pellet, L, Moritz, J T, Epstein, P N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Biological and medical sciences Cell death Cell Degranulation - drug effects Cell Degranulation - physiology Cell research Culture Techniques Diabetes Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Diabetes. Impaired glucose tolerance DNA DNA Damage DNA methylation Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzymes Etiopathogenesis. Screening. Investigations. Target tissue resistance Evaluation Gene expression Genetic aspects Hyperglycemia - blood Hyperglycemia - chemically induced Islets of Langerhans - drug effects Islets of Langerhans - pathology Islets of Langerhans - physiopathology Medical sciences Metallothionein Metallothionein - metabolism Metallothionein - physiology Mice Mice, Inbred Strains Mice, Transgenic - genetics Necrosis Pancreas Proteins Streptozocin - antagonists & inhibitors Streptozocin - pharmacology Transgenic animals
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