A newborn with positive antiglobulin test whose mother took methyldopa in pregnancy
Methyldopa is known to cause the production of autoantibodies against red blood cells (RBCs), leading to a positive direct antiglobulin test (DAT) and hemolytic anemia. In about 20% of patients taking methyldopa, IgG autoantibodies develop against RBCs. However, most of the patients do not have hemo...
Gespeichert in:
| Veröffentlicht in: | Turkish journal of pediatrics 2008-11, Vol.50 (6), p.592 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 6 |
| container_start_page | 592 |
| container_title | Turkish journal of pediatrics |
| container_volume | 50 |
| creator | Ozdemir, Ozmert M A Ergin, Hacer Ince, Tülay |
| description | Methyldopa is known to cause the production of autoantibodies against red blood cells (RBCs), leading to a positive direct antiglobulin test (DAT) and hemolytic anemia. In about 20% of patients taking methyldopa, IgG autoantibodies develop against RBCs. However, most of the patients do not have hemolysis. A small percentage of such DAT-positive patients, about 2% of those taking methyldopa, develop an autoimmune hemolytic anemia (AIHA). The fact that the DAT is positive in the newborn with unconjugated hyperbilirubinemia is considered as an isoimmune hemolytic disease caused by blood group incompatibility. In this article, a newborn with jaundice and positive DAT without hemolysis is reported. Her mother had the history of taking methyldopa in her pregnancy. Thus, when newborns are detected with positive DAT and jaundice, without blood group incompatibility, mothers should be questioned regarding drugs used in their pregnancy. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_journals_216300057</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1644845771</sourcerecordid><originalsourceid>FETCH-LOGICAL-p236t-151f81c50ccc36b3e6c78530db893259f982f52a6b0cc2042224aa8e042e6ea03</originalsourceid><addsrcrecordid>eNo1kMtOwzAURL0A0VL4BWSxj3R9HeexrCpeUiUWwDqyk5smJbGD4xD174nUsppZHM2M5oqtAWIRxRLEit2O4xEAU8jTG7YSOWIaY7pmH1tuaTbOWz63oeGDG9vQ_hLXNrSHzpmpay0PNAY-N24k3rvQkOfBuW_eU2hOXeUGzRdo8HSw2panO3Zd626k-4tu2Nfz0-fuNdq_v7zttvtoQJmESChRZ6JUUJalTIykpEwzJaEyWS5R5XWeYa1QJ2YhEGJEjLXOaHGUkAa5YY_n3MG7n2mZWBzd5O1SWaBIJACodIEeLtBkeqqKwbe99qfi_wL5B_DwVwI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>216300057</pqid></control><display><type>article</type><title>A newborn with positive antiglobulin test whose mother took methyldopa in pregnancy</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Ozdemir, Ozmert M A ; Ergin, Hacer ; Ince, Tülay</creator><creatorcontrib>Ozdemir, Ozmert M A ; Ergin, Hacer ; Ince, Tülay</creatorcontrib><description>Methyldopa is known to cause the production of autoantibodies against red blood cells (RBCs), leading to a positive direct antiglobulin test (DAT) and hemolytic anemia. In about 20% of patients taking methyldopa, IgG autoantibodies develop against RBCs. However, most of the patients do not have hemolysis. A small percentage of such DAT-positive patients, about 2% of those taking methyldopa, develop an autoimmune hemolytic anemia (AIHA). The fact that the DAT is positive in the newborn with unconjugated hyperbilirubinemia is considered as an isoimmune hemolytic disease caused by blood group incompatibility. In this article, a newborn with jaundice and positive DAT without hemolysis is reported. Her mother had the history of taking methyldopa in her pregnancy. Thus, when newborns are detected with positive DAT and jaundice, without blood group incompatibility, mothers should be questioned regarding drugs used in their pregnancy.</description><identifier>ISSN: 0041-4301</identifier><identifier>PMID: 19227427</identifier><language>eng</language><publisher>Turkey: Hacettepe University Faculty of Medicine</publisher><subject>Antihypertensive Agents - administration & dosage ; Antihypertensive Agents - adverse effects ; Coombs Test ; Diagnosis, Differential ; Female ; Humans ; Hyperbilirubinemia - diagnosis ; Immunoglobulin G - blood ; Infant, Newborn ; Maternal-Fetal Exchange ; Methyldopa - administration & dosage ; Methyldopa - adverse effects ; Pregnancy</subject><ispartof>Turkish journal of pediatrics, 2008-11, Vol.50 (6), p.592</ispartof><rights>Copyright Hacettepe University Faculty of Medicine Nov/Dec 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19227427$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ozdemir, Ozmert M A</creatorcontrib><creatorcontrib>Ergin, Hacer</creatorcontrib><creatorcontrib>Ince, Tülay</creatorcontrib><title>A newborn with positive antiglobulin test whose mother took methyldopa in pregnancy</title><title>Turkish journal of pediatrics</title><addtitle>Turk J Pediatr</addtitle><description>Methyldopa is known to cause the production of autoantibodies against red blood cells (RBCs), leading to a positive direct antiglobulin test (DAT) and hemolytic anemia. In about 20% of patients taking methyldopa, IgG autoantibodies develop against RBCs. However, most of the patients do not have hemolysis. A small percentage of such DAT-positive patients, about 2% of those taking methyldopa, develop an autoimmune hemolytic anemia (AIHA). The fact that the DAT is positive in the newborn with unconjugated hyperbilirubinemia is considered as an isoimmune hemolytic disease caused by blood group incompatibility. In this article, a newborn with jaundice and positive DAT without hemolysis is reported. Her mother had the history of taking methyldopa in her pregnancy. Thus, when newborns are detected with positive DAT and jaundice, without blood group incompatibility, mothers should be questioned regarding drugs used in their pregnancy.</description><subject>Antihypertensive Agents - administration & dosage</subject><subject>Antihypertensive Agents - adverse effects</subject><subject>Coombs Test</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperbilirubinemia - diagnosis</subject><subject>Immunoglobulin G - blood</subject><subject>Infant, Newborn</subject><subject>Maternal-Fetal Exchange</subject><subject>Methyldopa - administration & dosage</subject><subject>Methyldopa - adverse effects</subject><subject>Pregnancy</subject><issn>0041-4301</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNo1kMtOwzAURL0A0VL4BWSxj3R9HeexrCpeUiUWwDqyk5smJbGD4xD174nUsppZHM2M5oqtAWIRxRLEit2O4xEAU8jTG7YSOWIaY7pmH1tuaTbOWz63oeGDG9vQ_hLXNrSHzpmpay0PNAY-N24k3rvQkOfBuW_eU2hOXeUGzRdo8HSw2panO3Zd626k-4tu2Nfz0-fuNdq_v7zttvtoQJmESChRZ6JUUJalTIykpEwzJaEyWS5R5XWeYa1QJ2YhEGJEjLXOaHGUkAa5YY_n3MG7n2mZWBzd5O1SWaBIJACodIEeLtBkeqqKwbe99qfi_wL5B_DwVwI</recordid><startdate>20081101</startdate><enddate>20081101</enddate><creator>Ozdemir, Ozmert M A</creator><creator>Ergin, Hacer</creator><creator>Ince, Tülay</creator><general>Hacettepe University Faculty of Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EDSIH</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20081101</creationdate><title>A newborn with positive antiglobulin test whose mother took methyldopa in pregnancy</title><author>Ozdemir, Ozmert M A ; Ergin, Hacer ; Ince, Tülay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p236t-151f81c50ccc36b3e6c78530db893259f982f52a6b0cc2042224aa8e042e6ea03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Antihypertensive Agents - administration & dosage</topic><topic>Antihypertensive Agents - adverse effects</topic><topic>Coombs Test</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperbilirubinemia - diagnosis</topic><topic>Immunoglobulin G - blood</topic><topic>Infant, Newborn</topic><topic>Maternal-Fetal Exchange</topic><topic>Methyldopa - administration & dosage</topic><topic>Methyldopa - adverse effects</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ozdemir, Ozmert M A</creatorcontrib><creatorcontrib>Ergin, Hacer</creatorcontrib><creatorcontrib>Ince, Tülay</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Turkey Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Turkish journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozdemir, Ozmert M A</au><au>Ergin, Hacer</au><au>Ince, Tülay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A newborn with positive antiglobulin test whose mother took methyldopa in pregnancy</atitle><jtitle>Turkish journal of pediatrics</jtitle><addtitle>Turk J Pediatr</addtitle><date>2008-11-01</date><risdate>2008</risdate><volume>50</volume><issue>6</issue><spage>592</spage><pages>592-</pages><issn>0041-4301</issn><abstract>Methyldopa is known to cause the production of autoantibodies against red blood cells (RBCs), leading to a positive direct antiglobulin test (DAT) and hemolytic anemia. In about 20% of patients taking methyldopa, IgG autoantibodies develop against RBCs. However, most of the patients do not have hemolysis. A small percentage of such DAT-positive patients, about 2% of those taking methyldopa, develop an autoimmune hemolytic anemia (AIHA). The fact that the DAT is positive in the newborn with unconjugated hyperbilirubinemia is considered as an isoimmune hemolytic disease caused by blood group incompatibility. In this article, a newborn with jaundice and positive DAT without hemolysis is reported. Her mother had the history of taking methyldopa in her pregnancy. Thus, when newborns are detected with positive DAT and jaundice, without blood group incompatibility, mothers should be questioned regarding drugs used in their pregnancy.</abstract><cop>Turkey</cop><pub>Hacettepe University Faculty of Medicine</pub><pmid>19227427</pmid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-4301 |
| ispartof | Turkish journal of pediatrics, 2008-11, Vol.50 (6), p.592 |
| issn | 0041-4301 |
| language | eng |
| recordid | cdi_proquest_journals_216300057 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Antihypertensive Agents - administration & dosage Antihypertensive Agents - adverse effects Coombs Test Diagnosis, Differential Female Humans Hyperbilirubinemia - diagnosis Immunoglobulin G - blood Infant, Newborn Maternal-Fetal Exchange Methyldopa - administration & dosage Methyldopa - adverse effects Pregnancy |
| title | A newborn with positive antiglobulin test whose mother took methyldopa in pregnancy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T19%3A32%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20newborn%20with%20positive%20antiglobulin%20test%20whose%20mother%20took%20methyldopa%20in%20pregnancy&rft.jtitle=Turkish%20journal%20of%20pediatrics&rft.au=Ozdemir,%20Ozmert%20M%20A&rft.date=2008-11-01&rft.volume=50&rft.issue=6&rft.spage=592&rft.pages=592-&rft.issn=0041-4301&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E1644845771%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=216300057&rft_id=info:pmid/19227427&rfr_iscdi=true |