A comparative study of the effects of medical versus surgical androgen deprivation therapy on health-related quality of life in patients with metastatic carcinoma prostate
INTRODUCTION: Androgen deprivation therapy (ADT) is known to adversely affect the quality of life (QoL). One may choose between surgical and medical forms depending on his economic status, education status, and taboos. The aim of this study was to assess the impact of medical versus surgical ADT on...
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| Veröffentlicht in: | Indian journal of cancer 2018-04, Vol.55 (2), p.148-153 |
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| creator | Singh, Prabhjot Agrawal, Tapan Yadav, Siddharth Nayak, Brusabhanu Seth, Amlesh Dogra, Prem |
| description | INTRODUCTION: Androgen deprivation therapy (ADT) is known to adversely affect the quality of life (QoL). One may choose between surgical and medical forms depending on his economic status, education status, and taboos. The aim of this study was to assess the impact of medical versus surgical ADT on health-related quality of life (HRQoL) in patients with metastatic cancer prostate in Indian population. MATERIALS AND METHODS: From July 2012 to December 2014, 50 patients (10 medical castration and 40 surgical castration) of hormone-naïve metastatic prostate cancer who were started on combined ADT were included in this study. Before starting therapy, baseline data and QoL score (short form [SF-36] scale) were noted and all patients were followed up at 3 months, 6 months, and 1 year. Baseline data and HRQoL at all time intervals between surgical and medical castration groups were compared. RESULTS: All patients, except two, completed the 1-year follow-up period. Patients who opted for medical castration were more educated and belonged to higher socioeconomic status. For all the domains of SF-36 QoL questionnaire, a similar improvement in the score was noted at first 3-month follow-up which deteriorated in the next follow-up at 6 months and then further at 1 year. There was no difference in HRQoL after medical or surgical castration. CONCLUSIONS: In patients with metastatic cancer, prostate initiation of ADT, irrespective of method, causes an initial improvement in HRQoL followed later by a more gradual decline below the baseline. |
| doi_str_mv | 10.4103/ijc.ijc_531_17 |
| format | Article |
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One may choose between surgical and medical forms depending on his economic status, education status, and taboos. The aim of this study was to assess the impact of medical versus surgical ADT on health-related quality of life (HRQoL) in patients with metastatic cancer prostate in Indian population. MATERIALS AND METHODS: From July 2012 to December 2014, 50 patients (10 medical castration and 40 surgical castration) of hormone-naïve metastatic prostate cancer who were started on combined ADT were included in this study. Before starting therapy, baseline data and QoL score (short form [SF-36] scale) were noted and all patients were followed up at 3 months, 6 months, and 1 year. Baseline data and HRQoL at all time intervals between surgical and medical castration groups were compared. RESULTS: All patients, except two, completed the 1-year follow-up period. Patients who opted for medical castration were more educated and belonged to higher socioeconomic status. For all the domains of SF-36 QoL questionnaire, a similar improvement in the score was noted at first 3-month follow-up which deteriorated in the next follow-up at 6 months and then further at 1 year. There was no difference in HRQoL after medical or surgical castration. CONCLUSIONS: In patients with metastatic cancer, prostate initiation of ADT, irrespective of method, causes an initial improvement in HRQoL followed later by a more gradual decline below the baseline.</description><identifier>ISSN: 0019-509X</identifier><identifier>EISSN: 1998-4774</identifier><identifier>DOI: 10.4103/ijc.ijc_531_17</identifier><identifier>PMID: 30604726</identifier><language>eng</language><publisher>India: Wolters Kluwer India Pvt. Ltd</publisher><subject>Aged ; Analysis ; Androgen Antagonists - pharmacology ; Androgen Antagonists - therapeutic use ; Androgen suppression therapy ; Androgens ; Anemia ; Cancer therapies ; Diagnosis ; Health aspects ; Humans ; Male ; Mental health ; Metastasis ; Middle Aged ; Mortality ; Neoplasm Metastasis ; Osteoporosis ; Pain ; Patients ; Prostate cancer ; Prostatic Neoplasms ; Quality of life ; Quality of Life - psychology ; Questionnaires ; Socioeconomic factors ; Studies ; Treatment Outcome</subject><ispartof>Indian journal of cancer, 2018-04, Vol.55 (2), p.148-153</ispartof><rights>COPYRIGHT 2018 Medknow Publications and Media Pvt. Ltd.</rights><rights>2018. This work is published under https://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-d4d7a4fa56dfe5e7ef0637436fbf7208cf50e655b4ea0a7741db3cf0ac60ae653</citedby><cites>FETCH-LOGICAL-c518t-d4d7a4fa56dfe5e7ef0637436fbf7208cf50e655b4ea0a7741db3cf0ac60ae653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27458,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30604726$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singh, Prabhjot</creatorcontrib><creatorcontrib>Agrawal, Tapan</creatorcontrib><creatorcontrib>Yadav, Siddharth</creatorcontrib><creatorcontrib>Nayak, Brusabhanu</creatorcontrib><creatorcontrib>Seth, Amlesh</creatorcontrib><creatorcontrib>Dogra, Prem</creatorcontrib><title>A comparative study of the effects of medical versus surgical androgen deprivation therapy on health-related quality of life in patients with metastatic carcinoma prostate</title><title>Indian journal of cancer</title><addtitle>Indian J Cancer</addtitle><description>INTRODUCTION: Androgen deprivation therapy (ADT) is known to adversely affect the quality of life (QoL). One may choose between surgical and medical forms depending on his economic status, education status, and taboos. The aim of this study was to assess the impact of medical versus surgical ADT on health-related quality of life (HRQoL) in patients with metastatic cancer prostate in Indian population. MATERIALS AND METHODS: From July 2012 to December 2014, 50 patients (10 medical castration and 40 surgical castration) of hormone-naïve metastatic prostate cancer who were started on combined ADT were included in this study. Before starting therapy, baseline data and QoL score (short form [SF-36] scale) were noted and all patients were followed up at 3 months, 6 months, and 1 year. Baseline data and HRQoL at all time intervals between surgical and medical castration groups were compared. RESULTS: All patients, except two, completed the 1-year follow-up period. Patients who opted for medical castration were more educated and belonged to higher socioeconomic status. For all the domains of SF-36 QoL questionnaire, a similar improvement in the score was noted at first 3-month follow-up which deteriorated in the next follow-up at 6 months and then further at 1 year. There was no difference in HRQoL after medical or surgical castration. CONCLUSIONS: In patients with metastatic cancer, prostate initiation of ADT, irrespective of method, causes an initial improvement in HRQoL followed later by a more gradual decline below the baseline.</description><subject>Aged</subject><subject>Analysis</subject><subject>Androgen Antagonists - pharmacology</subject><subject>Androgen Antagonists - therapeutic use</subject><subject>Androgen suppression therapy</subject><subject>Androgens</subject><subject>Anemia</subject><subject>Cancer therapies</subject><subject>Diagnosis</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Male</subject><subject>Mental health</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Neoplasm Metastasis</subject><subject>Osteoporosis</subject><subject>Pain</subject><subject>Patients</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms</subject><subject>Quality of life</subject><subject>Quality of Life - psychology</subject><subject>Questionnaires</subject><subject>Socioeconomic factors</subject><subject>Studies</subject><subject>Treatment Outcome</subject><issn>0019-509X</issn><issn>1998-4774</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1UluLEzEUHkRx6-qrjxIQfJuazH0ea1l1ZcEXBd9Cmpy06WaSbpJp2d_kn_TMtusFKkMYcvJd4Dtflr1mdF4xWr43WznHw-uScdY-yWas77u8atvqaTajlPV5TfsfF9mLGLeUFmVRdc-zi5I2tGqLZpb9XBDph50IIpk9kJhGdU-8JmkDBLQGmeJ0HUAZKSzZQ4hjJHEM64e7cCr4NTiiYBfMHkW8m7hB7FDGkQ0ImzZ5ACsSKHI3CmvSg4E1GohxZIcccOhyMGmDPknEhCNJpAjSOD8Isgt-msHL7JkWNsKr0_8y-_7x6tvyc37z9dP1cnGTy5p1KVeVakWlRd0oDTW0oGlTtlXZ6JVuC9pJXVNo6npVgaACk2JqVUpNhWyowIfyMnt71EXjuxFi4ls_BoeWvGBN0TeUdd0f1FpY4MZpn4KQg4mSL-qmK2hfdwxR-RkUJoYRWe9AGxz_g5-fweOnYDDyLOHdX4Rj3tHbcdpEPKssMc4YQHPc2CDCPWeUT13iU4-uvyxPXULCm1MM4wr3_xv-WB4EfDgCDt4mLMatHQ8QOGJvnT_8R5azquML_li68hcgUN99</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Singh, Prabhjot</creator><creator>Agrawal, Tapan</creator><creator>Yadav, Siddharth</creator><creator>Nayak, Brusabhanu</creator><creator>Seth, Amlesh</creator><creator>Dogra, Prem</creator><general>Wolters Kluwer India Pvt. 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Nayak, Brusabhanu ; Seth, Amlesh ; Dogra, Prem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c518t-d4d7a4fa56dfe5e7ef0637436fbf7208cf50e655b4ea0a7741db3cf0ac60ae653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Analysis</topic><topic>Androgen Antagonists - pharmacology</topic><topic>Androgen Antagonists - therapeutic use</topic><topic>Androgen suppression therapy</topic><topic>Androgens</topic><topic>Anemia</topic><topic>Cancer therapies</topic><topic>Diagnosis</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Male</topic><topic>Mental health</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Neoplasm Metastasis</topic><topic>Osteoporosis</topic><topic>Pain</topic><topic>Patients</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms</topic><topic>Quality of life</topic><topic>Quality of Life - psychology</topic><topic>Questionnaires</topic><topic>Socioeconomic factors</topic><topic>Studies</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singh, Prabhjot</creatorcontrib><creatorcontrib>Agrawal, Tapan</creatorcontrib><creatorcontrib>Yadav, Siddharth</creatorcontrib><creatorcontrib>Nayak, Brusabhanu</creatorcontrib><creatorcontrib>Seth, Amlesh</creatorcontrib><creatorcontrib>Dogra, Prem</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Indian journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, Prabhjot</au><au>Agrawal, Tapan</au><au>Yadav, Siddharth</au><au>Nayak, Brusabhanu</au><au>Seth, Amlesh</au><au>Dogra, Prem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparative study of the effects of medical versus surgical androgen deprivation therapy on health-related quality of life in patients with metastatic carcinoma prostate</atitle><jtitle>Indian journal of cancer</jtitle><addtitle>Indian J Cancer</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>55</volume><issue>2</issue><spage>148</spage><epage>153</epage><pages>148-153</pages><issn>0019-509X</issn><eissn>1998-4774</eissn><abstract>INTRODUCTION: Androgen deprivation therapy (ADT) is known to adversely affect the quality of life (QoL). One may choose between surgical and medical forms depending on his economic status, education status, and taboos. The aim of this study was to assess the impact of medical versus surgical ADT on health-related quality of life (HRQoL) in patients with metastatic cancer prostate in Indian population. MATERIALS AND METHODS: From July 2012 to December 2014, 50 patients (10 medical castration and 40 surgical castration) of hormone-naïve metastatic prostate cancer who were started on combined ADT were included in this study. Before starting therapy, baseline data and QoL score (short form [SF-36] scale) were noted and all patients were followed up at 3 months, 6 months, and 1 year. Baseline data and HRQoL at all time intervals between surgical and medical castration groups were compared. RESULTS: All patients, except two, completed the 1-year follow-up period. Patients who opted for medical castration were more educated and belonged to higher socioeconomic status. For all the domains of SF-36 QoL questionnaire, a similar improvement in the score was noted at first 3-month follow-up which deteriorated in the next follow-up at 6 months and then further at 1 year. There was no difference in HRQoL after medical or surgical castration. CONCLUSIONS: In patients with metastatic cancer, prostate initiation of ADT, irrespective of method, causes an initial improvement in HRQoL followed later by a more gradual decline below the baseline.</abstract><cop>India</cop><pub>Wolters Kluwer India Pvt. Ltd</pub><pmid>30604726</pmid><doi>10.4103/ijc.ijc_531_17</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Indian journal of cancer, 2018-04, Vol.55 (2), p.148-153 |
| issn | 0019-509X 1998-4774 |
| language | eng |
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| subjects | Aged Analysis Androgen Antagonists - pharmacology Androgen Antagonists - therapeutic use Androgen suppression therapy Androgens Anemia Cancer therapies Diagnosis Health aspects Humans Male Mental health Metastasis Middle Aged Mortality Neoplasm Metastasis Osteoporosis Pain Patients Prostate cancer Prostatic Neoplasms Quality of life Quality of Life - psychology Questionnaires Socioeconomic factors Studies Treatment Outcome |
| title | A comparative study of the effects of medical versus surgical androgen deprivation therapy on health-related quality of life in patients with metastatic carcinoma prostate |
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