Diet supplemented with phytochemical epigallocatechin gallate and probiotic Lactobacillus fermentum confers second generation synbiotic effects by modulating cellular immune responses and antioxidant capacity in aging mice

Purpose In the present study, we systematically identified and evaluated a synbiotic combination of phytochemical epigallocatechin gallate (EGCG) and probiotic bacteria in amelioration of immunosenescence and oxidative stress in aged mice. Methods Inhibitory effects of EGCG against different bacteri...

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Veröffentlicht in:	European journal of nutrition 2019-10, Vol.58 (7), p.2943-2957
Hauptverfasser:	Sharma, Rohit, Kumari, Madhu, Kumari, Amita, Sharma, Anamika, Gulati, Ashu, Gupta, Mahesh, Padwad, Yogendra
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - drug effects Animals Antioxidants Antioxidants - administration & dosage Antioxidants - pharmacology Bacteria Catechin - administration & dosage Catechin - analogs & derivatives Catechin - pharmacology CD3 antigen Cell activation Cell death Chemistry Chemistry and Materials Science Cytokines Diet Diet - methods Dietary supplements Disease Models, Animal Epigallocatechin gallate Epigallocatechin-3-gallate GA-binding protein Immune response Immune response (cell-mediated) Immunity, Cellular - drug effects Immunosenescence Immunosenescence - drug effects Inflammation Lactobacillus fermentum Liver Lymphocytes T Male Mice Nutrition Original Contribution Oxidative stress Oxidative Stress - drug effects Phytochemicals Prebiotics Probiotics Probiotics - administration & dosage Probiotics - pharmacology Rodents Spleen Synbiotics - administration & dosage Yogurt
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