Patients' perceptions of isotretinoin, depression and suicide

Isotretinoin is an effective acne medication. The evidence for it causing depression and suicide, although widely publicised, remains uncertain. Twenty-six semi-structured interviews with patients with acne were coded and subjected to thematic analysis. Isotretinoin was perceived to be effective but dangerous. The most well known adverse effects were depression and suicide. The overemphasis of serious psychological adverse events in patients might discourage the use of isotretinoin by those who might benefit from it.