Detection of galectin-3 in patients with inflammatory bowel diseases: new serum marker of active forms of IBD?
Objective It is an open question whether multifunctional galectin-3 can be a serum marker in inflammatory bowel disease. Methods Western blots and commercial ELISA detected and quantitated the lectin immunocytochemistry using double labeling localized it in tissue sections. Results Serum concentrati...
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| Veröffentlicht in: | Inflammation research 2009-08, Vol.58 (8), p.503-512 |
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| creator | Frol’ová, Lenka Smetana, Karel Borovská, Dana Kitanovičová, Andrea Klimešová, Klára Janatková, Ivana Malíčková, Karin Lukáš, Milan Drastich, Pavel Beneš, Zdeněk Tučková, Ludmila Manning, Joachim C. André, Sabine Gabius, Hans-Joachim Tlaskalová-Hogenová, Helena |
| description | Objective
It is an open question whether multifunctional galectin-3 can be a serum marker in inflammatory bowel disease.
Methods
Western blots and commercial ELISA detected and quantitated the lectin immunocytochemistry using double labeling localized it in tissue sections.
Results
Serum concentrations were significantly increased in specimen of patients with active and remission-stage ulcerative colitis and Crohn’s disease, associated with emerging positivity of CD14
+
cells.
Conclusion
Enhanced concentration of galectin-3 in serum reflects presence of disease and points to its involvement in the pathogenesis. |
| doi_str_mv | 10.1007/s00011-009-0016-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_216243777</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1791731781</sourcerecordid><originalsourceid>FETCH-LOGICAL-c369t-4626b4bc07fcd0293c94ac0e1192a0f5923434b2b7f66013b6a244dd16efb7ec3</originalsourceid><addsrcrecordid>eNp1kE1PwzAMhiMEYmPwA7igiHvB-VjackGw8TFpEheQuEVp64yOtR1Jy7R_T6pN2olD5Nh-_dp6CLlkcMMA4lsPAIxFAGl4TEXJERkyySFKIfk8Dn_gIhKJgAE5834Z1AlP-CkZsJTHjI1hSOoptpi3ZVPTxtKFWfVJHQla1nRt2hLr1tNN2X6Fgl2ZqjJt47Y0aza4okXp0Xj0d7TGDfXouopWxn2j681McPpFahtX-T6fPU7vz8mJNSuPF_s4Ih_PT--T12j-9jKbPMyjXKi0jaTiKpNZDrHNC-CpyFNpckAWDjdgxykXUsiMZ7FVCpjIlOFSFgVTaLMYczEi1zvftWt-OvStXjadq8NKzZniUsRxHERsJ8pd471Dq9euDPdvNQPdA9Y7wDoA1j1gnYSZq71xl1VYHCb2RIOA7wQ-tOoFusPm_13_AEirhaM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>216243777</pqid></control><display><type>article</type><title>Detection of galectin-3 in patients with inflammatory bowel diseases: new serum marker of active forms of IBD?</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Frol’ová, Lenka ; Smetana, Karel ; Borovská, Dana ; Kitanovičová, Andrea ; Klimešová, Klára ; Janatková, Ivana ; Malíčková, Karin ; Lukáš, Milan ; Drastich, Pavel ; Beneš, Zdeněk ; Tučková, Ludmila ; Manning, Joachim C. ; André, Sabine ; Gabius, Hans-Joachim ; Tlaskalová-Hogenová, Helena</creator><creatorcontrib>Frol’ová, Lenka ; Smetana, Karel ; Borovská, Dana ; Kitanovičová, Andrea ; Klimešová, Klára ; Janatková, Ivana ; Malíčková, Karin ; Lukáš, Milan ; Drastich, Pavel ; Beneš, Zdeněk ; Tučková, Ludmila ; Manning, Joachim C. ; André, Sabine ; Gabius, Hans-Joachim ; Tlaskalová-Hogenová, Helena</creatorcontrib><description>Objective
It is an open question whether multifunctional galectin-3 can be a serum marker in inflammatory bowel disease.
Methods
Western blots and commercial ELISA detected and quantitated the lectin immunocytochemistry using double labeling localized it in tissue sections.
Results
Serum concentrations were significantly increased in specimen of patients with active and remission-stage ulcerative colitis and Crohn’s disease, associated with emerging positivity of CD14
+
cells.
Conclusion
Enhanced concentration of galectin-3 in serum reflects presence of disease and points to its involvement in the pathogenesis.</description><identifier>ISSN: 1023-3830</identifier><identifier>EISSN: 1420-908X</identifier><identifier>DOI: 10.1007/s00011-009-0016-8</identifier><identifier>PMID: 19271150</identifier><language>eng</language><publisher>Basel: SP Birkhäuser Verlag Basel</publisher><subject>Allergology ; Animals ; Biomarkers ; Biomedical and Life Sciences ; Biomedicine ; Blotting, Western ; Colitis - chemically induced ; Colitis, Ulcerative - blood ; Colon - metabolism ; Crohn Disease - blood ; Dermatology ; Dextran Sulfate ; Electrophoresis, Polyacrylamide Gel ; Escherichia coli - metabolism ; Female ; Fluorescein-5-isothiocyanate ; Fluorescent Dyes ; Galectin 3 - blood ; Humans ; Immunohistochemistry ; Immunology ; Inflammatory Bowel Diseases - blood ; Inflammatory Bowel Diseases - chemically induced ; Inflammatory Bowel Diseases - diagnosis ; Lectins - metabolism ; Lipopolysaccharide Receptors - analysis ; Lipopolysaccharide Receptors - metabolism ; Mice ; Mice, Inbred BALB C ; Neurology ; Original Research Paper ; Pharmacology/Toxicology ; Rheumatology</subject><ispartof>Inflammation research, 2009-08, Vol.58 (8), p.503-512</ispartof><rights>Birkhäuser Verlag, Basel/Switzerland 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-4626b4bc07fcd0293c94ac0e1192a0f5923434b2b7f66013b6a244dd16efb7ec3</citedby><cites>FETCH-LOGICAL-c369t-4626b4bc07fcd0293c94ac0e1192a0f5923434b2b7f66013b6a244dd16efb7ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00011-009-0016-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00011-009-0016-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19271150$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Frol’ová, Lenka</creatorcontrib><creatorcontrib>Smetana, Karel</creatorcontrib><creatorcontrib>Borovská, Dana</creatorcontrib><creatorcontrib>Kitanovičová, Andrea</creatorcontrib><creatorcontrib>Klimešová, Klára</creatorcontrib><creatorcontrib>Janatková, Ivana</creatorcontrib><creatorcontrib>Malíčková, Karin</creatorcontrib><creatorcontrib>Lukáš, Milan</creatorcontrib><creatorcontrib>Drastich, Pavel</creatorcontrib><creatorcontrib>Beneš, Zdeněk</creatorcontrib><creatorcontrib>Tučková, Ludmila</creatorcontrib><creatorcontrib>Manning, Joachim C.</creatorcontrib><creatorcontrib>André, Sabine</creatorcontrib><creatorcontrib>Gabius, Hans-Joachim</creatorcontrib><creatorcontrib>Tlaskalová-Hogenová, Helena</creatorcontrib><title>Detection of galectin-3 in patients with inflammatory bowel diseases: new serum marker of active forms of IBD?</title><title>Inflammation research</title><addtitle>Inflamm. Res</addtitle><addtitle>Inflamm Res</addtitle><description>Objective
It is an open question whether multifunctional galectin-3 can be a serum marker in inflammatory bowel disease.
Methods
Western blots and commercial ELISA detected and quantitated the lectin immunocytochemistry using double labeling localized it in tissue sections.
Results
Serum concentrations were significantly increased in specimen of patients with active and remission-stage ulcerative colitis and Crohn’s disease, associated with emerging positivity of CD14
+
cells.
Conclusion
Enhanced concentration of galectin-3 in serum reflects presence of disease and points to its involvement in the pathogenesis.</description><subject>Allergology</subject><subject>Animals</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blotting, Western</subject><subject>Colitis - chemically induced</subject><subject>Colitis, Ulcerative - blood</subject><subject>Colon - metabolism</subject><subject>Crohn Disease - blood</subject><subject>Dermatology</subject><subject>Dextran Sulfate</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Escherichia coli - metabolism</subject><subject>Female</subject><subject>Fluorescein-5-isothiocyanate</subject><subject>Fluorescent Dyes</subject><subject>Galectin 3 - blood</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Immunology</subject><subject>Inflammatory Bowel Diseases - blood</subject><subject>Inflammatory Bowel Diseases - chemically induced</subject><subject>Inflammatory Bowel Diseases - diagnosis</subject><subject>Lectins - metabolism</subject><subject>Lipopolysaccharide Receptors - analysis</subject><subject>Lipopolysaccharide Receptors - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Neurology</subject><subject>Original Research Paper</subject><subject>Pharmacology/Toxicology</subject><subject>Rheumatology</subject><issn>1023-3830</issn><issn>1420-908X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE1PwzAMhiMEYmPwA7igiHvB-VjackGw8TFpEheQuEVp64yOtR1Jy7R_T6pN2olD5Nh-_dp6CLlkcMMA4lsPAIxFAGl4TEXJERkyySFKIfk8Dn_gIhKJgAE5834Z1AlP-CkZsJTHjI1hSOoptpi3ZVPTxtKFWfVJHQla1nRt2hLr1tNN2X6Fgl2ZqjJt47Y0aza4okXp0Xj0d7TGDfXouopWxn2j681McPpFahtX-T6fPU7vz8mJNSuPF_s4Ih_PT--T12j-9jKbPMyjXKi0jaTiKpNZDrHNC-CpyFNpckAWDjdgxykXUsiMZ7FVCpjIlOFSFgVTaLMYczEi1zvftWt-OvStXjadq8NKzZniUsRxHERsJ8pd471Dq9euDPdvNQPdA9Y7wDoA1j1gnYSZq71xl1VYHCb2RIOA7wQ-tOoFusPm_13_AEirhaM</recordid><startdate>20090801</startdate><enddate>20090801</enddate><creator>Frol’ová, Lenka</creator><creator>Smetana, Karel</creator><creator>Borovská, Dana</creator><creator>Kitanovičová, Andrea</creator><creator>Klimešová, Klára</creator><creator>Janatková, Ivana</creator><creator>Malíčková, Karin</creator><creator>Lukáš, Milan</creator><creator>Drastich, Pavel</creator><creator>Beneš, Zdeněk</creator><creator>Tučková, Ludmila</creator><creator>Manning, Joachim C.</creator><creator>André, Sabine</creator><creator>Gabius, Hans-Joachim</creator><creator>Tlaskalová-Hogenová, Helena</creator><general>SP Birkhäuser Verlag Basel</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20090801</creationdate><title>Detection of galectin-3 in patients with inflammatory bowel diseases: new serum marker of active forms of IBD?</title><author>Frol’ová, Lenka ; Smetana, Karel ; Borovská, Dana ; Kitanovičová, Andrea ; Klimešová, Klára ; Janatková, Ivana ; Malíčková, Karin ; Lukáš, Milan ; Drastich, Pavel ; Beneš, Zdeněk ; Tučková, Ludmila ; Manning, Joachim C. ; André, Sabine ; Gabius, Hans-Joachim ; Tlaskalová-Hogenová, Helena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-4626b4bc07fcd0293c94ac0e1192a0f5923434b2b7f66013b6a244dd16efb7ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Allergology</topic><topic>Animals</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blotting, Western</topic><topic>Colitis - chemically induced</topic><topic>Colitis, Ulcerative - blood</topic><topic>Colon - metabolism</topic><topic>Crohn Disease - blood</topic><topic>Dermatology</topic><topic>Dextran Sulfate</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Escherichia coli - metabolism</topic><topic>Female</topic><topic>Fluorescein-5-isothiocyanate</topic><topic>Fluorescent Dyes</topic><topic>Galectin 3 - blood</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Immunology</topic><topic>Inflammatory Bowel Diseases - blood</topic><topic>Inflammatory Bowel Diseases - chemically induced</topic><topic>Inflammatory Bowel Diseases - diagnosis</topic><topic>Lectins - metabolism</topic><topic>Lipopolysaccharide Receptors - analysis</topic><topic>Lipopolysaccharide Receptors - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Neurology</topic><topic>Original Research Paper</topic><topic>Pharmacology/Toxicology</topic><topic>Rheumatology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Frol’ová, Lenka</creatorcontrib><creatorcontrib>Smetana, Karel</creatorcontrib><creatorcontrib>Borovská, Dana</creatorcontrib><creatorcontrib>Kitanovičová, Andrea</creatorcontrib><creatorcontrib>Klimešová, Klára</creatorcontrib><creatorcontrib>Janatková, Ivana</creatorcontrib><creatorcontrib>Malíčková, Karin</creatorcontrib><creatorcontrib>Lukáš, Milan</creatorcontrib><creatorcontrib>Drastich, Pavel</creatorcontrib><creatorcontrib>Beneš, Zdeněk</creatorcontrib><creatorcontrib>Tučková, Ludmila</creatorcontrib><creatorcontrib>Manning, Joachim C.</creatorcontrib><creatorcontrib>André, Sabine</creatorcontrib><creatorcontrib>Gabius, Hans-Joachim</creatorcontrib><creatorcontrib>Tlaskalová-Hogenová, Helena</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Inflammation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Frol’ová, Lenka</au><au>Smetana, Karel</au><au>Borovská, Dana</au><au>Kitanovičová, Andrea</au><au>Klimešová, Klára</au><au>Janatková, Ivana</au><au>Malíčková, Karin</au><au>Lukáš, Milan</au><au>Drastich, Pavel</au><au>Beneš, Zdeněk</au><au>Tučková, Ludmila</au><au>Manning, Joachim C.</au><au>André, Sabine</au><au>Gabius, Hans-Joachim</au><au>Tlaskalová-Hogenová, Helena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of galectin-3 in patients with inflammatory bowel diseases: new serum marker of active forms of IBD?</atitle><jtitle>Inflammation research</jtitle><stitle>Inflamm. Res</stitle><addtitle>Inflamm Res</addtitle><date>2009-08-01</date><risdate>2009</risdate><volume>58</volume><issue>8</issue><spage>503</spage><epage>512</epage><pages>503-512</pages><issn>1023-3830</issn><eissn>1420-908X</eissn><abstract>Objective
It is an open question whether multifunctional galectin-3 can be a serum marker in inflammatory bowel disease.
Methods
Western blots and commercial ELISA detected and quantitated the lectin immunocytochemistry using double labeling localized it in tissue sections.
Results
Serum concentrations were significantly increased in specimen of patients with active and remission-stage ulcerative colitis and Crohn’s disease, associated with emerging positivity of CD14
+
cells.
Conclusion
Enhanced concentration of galectin-3 in serum reflects presence of disease and points to its involvement in the pathogenesis.</abstract><cop>Basel</cop><pub>SP Birkhäuser Verlag Basel</pub><pmid>19271150</pmid><doi>10.1007/s00011-009-0016-8</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1023-3830 |
| ispartof | Inflammation research, 2009-08, Vol.58 (8), p.503-512 |
| issn | 1023-3830 1420-908X |
| language | eng |
| recordid | cdi_proquest_journals_216243777 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Allergology Animals Biomarkers Biomedical and Life Sciences Biomedicine Blotting, Western Colitis - chemically induced Colitis, Ulcerative - blood Colon - metabolism Crohn Disease - blood Dermatology Dextran Sulfate Electrophoresis, Polyacrylamide Gel Escherichia coli - metabolism Female Fluorescein-5-isothiocyanate Fluorescent Dyes Galectin 3 - blood Humans Immunohistochemistry Immunology Inflammatory Bowel Diseases - blood Inflammatory Bowel Diseases - chemically induced Inflammatory Bowel Diseases - diagnosis Lectins - metabolism Lipopolysaccharide Receptors - analysis Lipopolysaccharide Receptors - metabolism Mice Mice, Inbred BALB C Neurology Original Research Paper Pharmacology/Toxicology Rheumatology |
| title | Detection of galectin-3 in patients with inflammatory bowel diseases: new serum marker of active forms of IBD? |
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