Xenobiotic pregnane X receptor promotes neointimal formation in balloon‐injured rat carotid arteries
Pregnane X receptor (PXR) is a member of nuclear receptor superfamily and responsible for the detoxification of xenobiotics. Recent studies demonstrated that PXR was also expressed in the vasculature and protected the vessels from endogenous and exogenous insults, thus representing a novel gatekeepe...
Gespeichert in:
| Veröffentlicht in: | Journal of cellular physiology 2019-04, Vol.234 (4), p.4342-4351 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4351 |
|---|---|
| container_issue | 4 |
| container_start_page | 4342 |
| container_title | Journal of cellular physiology |
| container_volume | 234 |
| creator | Zhang, Meiqian Zhang, Zihui Xie, Xinya Yao, Qinyu Liu, Jia Lai, Baochang Xiao, Lei Wang, Nanping |
| description | Pregnane X receptor (PXR) is a member of nuclear receptor superfamily and responsible for the detoxification of xenobiotics. Recent studies demonstrated that PXR was also expressed in the vasculature and protected the vessels from endogenous and exogenous insults, thus representing a novel gatekeeper in vascular defense. In this study, we examined the potential function of PXR in the neointimal formation following vascular injury. In the rat carotid artery after balloon injury, overexpression of a constitutively active PXR increased the intima‐to‐media ratio in the injured region. PXR increased cell proliferation and migration in cultured rat aortic smooth muscle cells (SMCs) by inducing the expressions of cyclins (cyclin A, D1, and E) and cyclin‐dependent kinase 2. In addition, PXR increased the phosphorylation and activation of extracellular‐signal‐regulated kinase 1/2 (ERK1/2) and p38 mitogen‐activated protein kinase (MAPK). Inactivation of ERK1/2 and p38 MAPK pathways using selective inhibitors (U0126 and SB203580) abrogated PXR‐induced SMC proliferation and migration. Furthermore, cigarette smoke particles (CSP) activated PXR in SMCs. Knockdown of PXR by small interfering RNA suppressed the cell proliferation, migration, and activation of the MAPK pathways by CSP. These findings suggested a novel role for PXR in promoting SMC proliferation and migration, and neointimal hyperplasia. Therefore, PXR may be a potential therapeutic target for vascular disease related to xenobiotics such as cigarette smoking and other environmental pollutants.
Our findings suggested a novel role for pregnane X receptor (PXR) in promoting smooth muscle cell (SMC) proliferation and migration, and neointimal hyperplasia. In the rat carotid artery after balloon injury, overexpression of a constitutively active PXR increased the intima‐to‐media ratio in the injured region. PXR increased cell proliferation and migration in cultured rat aortic SMCs. Therefore, PXR may be a potential therapeutic target for vascular disease related to xenobiotics such as cigarette smoking and other environmental pollutants. |
| doi_str_mv | 10.1002/jcp.27215 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2162387132</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2162387132</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3535-6cd2feae34d585a84494035cf20168703d5880cdfebaef55651d063f026826e83</originalsourceid><addsrcrecordid>eNp1kEtOwzAQhi0EoqWw4ALIEisWaf2IE2eJKp6qBAuQuoscZ4xcpXZwUqHuOAJn5CQYUtixGmnm0zczP0KnlEwpIWy20u2U5YyKPTSmpMiTNBNsH43jjCaFSOkIHXXdihBSFJwfohEnlDMp0zEyS3C-sr63GrcBXpxygJc4gIa29yH2_Nr30GEH3rrerlWDjQ9r1VvvsHW4Uk3jvft8_7ButQlQ46B6rFWIyhqr0EOw0B2jA6OaDk52dYKer6-e5rfJ4uHmbn65SDQXXCSZrpkBBTythRRKpmmREi60YYRmMic8tiXRtYFKgREiE7QmGTeEZZJlIPkEnQ_eePfrBrq-XPlNcHFlyWjGuMzj45G6GCgdfNcFMGUb4mdhW1JSfidaxkTLn0Qje7Yzbqo11H_kb4QRmA3Am21g-7-pvJ8_DsovgXOBlw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2162387132</pqid></control><display><type>article</type><title>Xenobiotic pregnane X receptor promotes neointimal formation in balloon‐injured rat carotid arteries</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Zhang, Meiqian ; Zhang, Zihui ; Xie, Xinya ; Yao, Qinyu ; Liu, Jia ; Lai, Baochang ; Xiao, Lei ; Wang, Nanping</creator><creatorcontrib>Zhang, Meiqian ; Zhang, Zihui ; Xie, Xinya ; Yao, Qinyu ; Liu, Jia ; Lai, Baochang ; Xiao, Lei ; Wang, Nanping</creatorcontrib><description>Pregnane X receptor (PXR) is a member of nuclear receptor superfamily and responsible for the detoxification of xenobiotics. Recent studies demonstrated that PXR was also expressed in the vasculature and protected the vessels from endogenous and exogenous insults, thus representing a novel gatekeeper in vascular defense. In this study, we examined the potential function of PXR in the neointimal formation following vascular injury. In the rat carotid artery after balloon injury, overexpression of a constitutively active PXR increased the intima‐to‐media ratio in the injured region. PXR increased cell proliferation and migration in cultured rat aortic smooth muscle cells (SMCs) by inducing the expressions of cyclins (cyclin A, D1, and E) and cyclin‐dependent kinase 2. In addition, PXR increased the phosphorylation and activation of extracellular‐signal‐regulated kinase 1/2 (ERK1/2) and p38 mitogen‐activated protein kinase (MAPK). Inactivation of ERK1/2 and p38 MAPK pathways using selective inhibitors (U0126 and SB203580) abrogated PXR‐induced SMC proliferation and migration. Furthermore, cigarette smoke particles (CSP) activated PXR in SMCs. Knockdown of PXR by small interfering RNA suppressed the cell proliferation, migration, and activation of the MAPK pathways by CSP. These findings suggested a novel role for PXR in promoting SMC proliferation and migration, and neointimal hyperplasia. Therefore, PXR may be a potential therapeutic target for vascular disease related to xenobiotics such as cigarette smoking and other environmental pollutants.
Our findings suggested a novel role for pregnane X receptor (PXR) in promoting smooth muscle cell (SMC) proliferation and migration, and neointimal hyperplasia. In the rat carotid artery after balloon injury, overexpression of a constitutively active PXR increased the intima‐to‐media ratio in the injured region. PXR increased cell proliferation and migration in cultured rat aortic SMCs. Therefore, PXR may be a potential therapeutic target for vascular disease related to xenobiotics such as cigarette smoking and other environmental pollutants.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.27215</identifier><identifier>PMID: 30132884</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Angioplasty, Balloon ; Animals ; Aorta ; Arteries ; Blood vessels ; Carotid arteries ; Carotid Arteries - metabolism ; Carotid Arteries - pathology ; Carotid artery ; Carotid Artery Injuries - etiology ; Carotid Artery Injuries - metabolism ; Carotid Artery Injuries - pathology ; Cell activation ; Cell growth ; Cell migration ; Cell Movement ; Cell Proliferation ; Cells, Cultured ; Cigarette smoke ; Cigarette smoking ; Cigarettes ; Cyclin A ; Cyclins - metabolism ; Deactivation ; Detoxification ; Disease Models, Animal ; Extracellular signal-regulated kinase ; Extracellular Signal-Regulated MAP Kinases - metabolism ; Hyperplasia ; Inactivation ; Injuries ; Kinases ; Male ; MAP kinase ; migration ; Muscle, Smooth, Vascular - drug effects ; Muscle, Smooth, Vascular - metabolism ; Muscle, Smooth, Vascular - pathology ; Muscles ; Myocytes, Smooth Muscle - drug effects ; Myocytes, Smooth Muscle - metabolism ; Myocytes, Smooth Muscle - pathology ; Neointima ; neointimal formation ; p38 Mitogen-Activated Protein Kinases - metabolism ; Phosphorylation ; Pollutants ; pregnane X receptor (PXR) ; Pregnane X Receptor - agonists ; Pregnane X Receptor - metabolism ; proliferation ; Protein kinase ; Proteins ; Rats, Sprague-Dawley ; Ribonucleic acid ; RNA ; Rodents ; Signal Transduction ; siRNA ; Smoke ; Smoke - adverse effects ; Smooth muscle ; smooth muscle cell (SMC) ; Therapeutic applications ; Tobacco Products - adverse effects ; Vascular diseases ; Xenobiotics</subject><ispartof>Journal of cellular physiology, 2019-04, Vol.234 (4), p.4342-4351</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3535-6cd2feae34d585a84494035cf20168703d5880cdfebaef55651d063f026826e83</citedby><cites>FETCH-LOGICAL-c3535-6cd2feae34d585a84494035cf20168703d5880cdfebaef55651d063f026826e83</cites><orcidid>0000-0002-8528-8132</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.27215$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.27215$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30132884$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Meiqian</creatorcontrib><creatorcontrib>Zhang, Zihui</creatorcontrib><creatorcontrib>Xie, Xinya</creatorcontrib><creatorcontrib>Yao, Qinyu</creatorcontrib><creatorcontrib>Liu, Jia</creatorcontrib><creatorcontrib>Lai, Baochang</creatorcontrib><creatorcontrib>Xiao, Lei</creatorcontrib><creatorcontrib>Wang, Nanping</creatorcontrib><title>Xenobiotic pregnane X receptor promotes neointimal formation in balloon‐injured rat carotid arteries</title><title>Journal of cellular physiology</title><addtitle>J Cell Physiol</addtitle><description>Pregnane X receptor (PXR) is a member of nuclear receptor superfamily and responsible for the detoxification of xenobiotics. Recent studies demonstrated that PXR was also expressed in the vasculature and protected the vessels from endogenous and exogenous insults, thus representing a novel gatekeeper in vascular defense. In this study, we examined the potential function of PXR in the neointimal formation following vascular injury. In the rat carotid artery after balloon injury, overexpression of a constitutively active PXR increased the intima‐to‐media ratio in the injured region. PXR increased cell proliferation and migration in cultured rat aortic smooth muscle cells (SMCs) by inducing the expressions of cyclins (cyclin A, D1, and E) and cyclin‐dependent kinase 2. In addition, PXR increased the phosphorylation and activation of extracellular‐signal‐regulated kinase 1/2 (ERK1/2) and p38 mitogen‐activated protein kinase (MAPK). Inactivation of ERK1/2 and p38 MAPK pathways using selective inhibitors (U0126 and SB203580) abrogated PXR‐induced SMC proliferation and migration. Furthermore, cigarette smoke particles (CSP) activated PXR in SMCs. Knockdown of PXR by small interfering RNA suppressed the cell proliferation, migration, and activation of the MAPK pathways by CSP. These findings suggested a novel role for PXR in promoting SMC proliferation and migration, and neointimal hyperplasia. Therefore, PXR may be a potential therapeutic target for vascular disease related to xenobiotics such as cigarette smoking and other environmental pollutants.
Our findings suggested a novel role for pregnane X receptor (PXR) in promoting smooth muscle cell (SMC) proliferation and migration, and neointimal hyperplasia. In the rat carotid artery after balloon injury, overexpression of a constitutively active PXR increased the intima‐to‐media ratio in the injured region. PXR increased cell proliferation and migration in cultured rat aortic SMCs. Therefore, PXR may be a potential therapeutic target for vascular disease related to xenobiotics such as cigarette smoking and other environmental pollutants.</description><subject>Angioplasty, Balloon</subject><subject>Animals</subject><subject>Aorta</subject><subject>Arteries</subject><subject>Blood vessels</subject><subject>Carotid arteries</subject><subject>Carotid Arteries - metabolism</subject><subject>Carotid Arteries - pathology</subject><subject>Carotid artery</subject><subject>Carotid Artery Injuries - etiology</subject><subject>Carotid Artery Injuries - metabolism</subject><subject>Carotid Artery Injuries - pathology</subject><subject>Cell activation</subject><subject>Cell growth</subject><subject>Cell migration</subject><subject>Cell Movement</subject><subject>Cell Proliferation</subject><subject>Cells, Cultured</subject><subject>Cigarette smoke</subject><subject>Cigarette smoking</subject><subject>Cigarettes</subject><subject>Cyclin A</subject><subject>Cyclins - metabolism</subject><subject>Deactivation</subject><subject>Detoxification</subject><subject>Disease Models, Animal</subject><subject>Extracellular signal-regulated kinase</subject><subject>Extracellular Signal-Regulated MAP Kinases - metabolism</subject><subject>Hyperplasia</subject><subject>Inactivation</subject><subject>Injuries</subject><subject>Kinases</subject><subject>Male</subject><subject>MAP kinase</subject><subject>migration</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Muscle, Smooth, Vascular - metabolism</subject><subject>Muscle, Smooth, Vascular - pathology</subject><subject>Muscles</subject><subject>Myocytes, Smooth Muscle - drug effects</subject><subject>Myocytes, Smooth Muscle - metabolism</subject><subject>Myocytes, Smooth Muscle - pathology</subject><subject>Neointima</subject><subject>neointimal formation</subject><subject>p38 Mitogen-Activated Protein Kinases - metabolism</subject><subject>Phosphorylation</subject><subject>Pollutants</subject><subject>pregnane X receptor (PXR)</subject><subject>Pregnane X Receptor - agonists</subject><subject>Pregnane X Receptor - metabolism</subject><subject>proliferation</subject><subject>Protein kinase</subject><subject>Proteins</subject><subject>Rats, Sprague-Dawley</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Rodents</subject><subject>Signal Transduction</subject><subject>siRNA</subject><subject>Smoke</subject><subject>Smoke - adverse effects</subject><subject>Smooth muscle</subject><subject>smooth muscle cell (SMC)</subject><subject>Therapeutic applications</subject><subject>Tobacco Products - adverse effects</subject><subject>Vascular diseases</subject><subject>Xenobiotics</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtOwzAQhi0EoqWw4ALIEisWaf2IE2eJKp6qBAuQuoscZ4xcpXZwUqHuOAJn5CQYUtixGmnm0zczP0KnlEwpIWy20u2U5YyKPTSmpMiTNBNsH43jjCaFSOkIHXXdihBSFJwfohEnlDMp0zEyS3C-sr63GrcBXpxygJc4gIa29yH2_Nr30GEH3rrerlWDjQ9r1VvvsHW4Uk3jvft8_7ButQlQ46B6rFWIyhqr0EOw0B2jA6OaDk52dYKer6-e5rfJ4uHmbn65SDQXXCSZrpkBBTythRRKpmmREi60YYRmMic8tiXRtYFKgREiE7QmGTeEZZJlIPkEnQ_eePfrBrq-XPlNcHFlyWjGuMzj45G6GCgdfNcFMGUb4mdhW1JSfidaxkTLn0Qje7Yzbqo11H_kb4QRmA3Am21g-7-pvJ8_DsovgXOBlw</recordid><startdate>201904</startdate><enddate>201904</enddate><creator>Zhang, Meiqian</creator><creator>Zhang, Zihui</creator><creator>Xie, Xinya</creator><creator>Yao, Qinyu</creator><creator>Liu, Jia</creator><creator>Lai, Baochang</creator><creator>Xiao, Lei</creator><creator>Wang, Nanping</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0002-8528-8132</orcidid></search><sort><creationdate>201904</creationdate><title>Xenobiotic pregnane X receptor promotes neointimal formation in balloon‐injured rat carotid arteries</title><author>Zhang, Meiqian ; Zhang, Zihui ; Xie, Xinya ; Yao, Qinyu ; Liu, Jia ; Lai, Baochang ; Xiao, Lei ; Wang, Nanping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3535-6cd2feae34d585a84494035cf20168703d5880cdfebaef55651d063f026826e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Angioplasty, Balloon</topic><topic>Animals</topic><topic>Aorta</topic><topic>Arteries</topic><topic>Blood vessels</topic><topic>Carotid arteries</topic><topic>Carotid Arteries - metabolism</topic><topic>Carotid Arteries - pathology</topic><topic>Carotid artery</topic><topic>Carotid Artery Injuries - etiology</topic><topic>Carotid Artery Injuries - metabolism</topic><topic>Carotid Artery Injuries - pathology</topic><topic>Cell activation</topic><topic>Cell growth</topic><topic>Cell migration</topic><topic>Cell Movement</topic><topic>Cell Proliferation</topic><topic>Cells, Cultured</topic><topic>Cigarette smoke</topic><topic>Cigarette smoking</topic><topic>Cigarettes</topic><topic>Cyclin A</topic><topic>Cyclins - metabolism</topic><topic>Deactivation</topic><topic>Detoxification</topic><topic>Disease Models, Animal</topic><topic>Extracellular signal-regulated kinase</topic><topic>Extracellular Signal-Regulated MAP Kinases - metabolism</topic><topic>Hyperplasia</topic><topic>Inactivation</topic><topic>Injuries</topic><topic>Kinases</topic><topic>Male</topic><topic>MAP kinase</topic><topic>migration</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Muscle, Smooth, Vascular - metabolism</topic><topic>Muscle, Smooth, Vascular - pathology</topic><topic>Muscles</topic><topic>Myocytes, Smooth Muscle - drug effects</topic><topic>Myocytes, Smooth Muscle - metabolism</topic><topic>Myocytes, Smooth Muscle - pathology</topic><topic>Neointima</topic><topic>neointimal formation</topic><topic>p38 Mitogen-Activated Protein Kinases - metabolism</topic><topic>Phosphorylation</topic><topic>Pollutants</topic><topic>pregnane X receptor (PXR)</topic><topic>Pregnane X Receptor - agonists</topic><topic>Pregnane X Receptor - metabolism</topic><topic>proliferation</topic><topic>Protein kinase</topic><topic>Proteins</topic><topic>Rats, Sprague-Dawley</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Rodents</topic><topic>Signal Transduction</topic><topic>siRNA</topic><topic>Smoke</topic><topic>Smoke - adverse effects</topic><topic>Smooth muscle</topic><topic>smooth muscle cell (SMC)</topic><topic>Therapeutic applications</topic><topic>Tobacco Products - adverse effects</topic><topic>Vascular diseases</topic><topic>Xenobiotics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Meiqian</creatorcontrib><creatorcontrib>Zhang, Zihui</creatorcontrib><creatorcontrib>Xie, Xinya</creatorcontrib><creatorcontrib>Yao, Qinyu</creatorcontrib><creatorcontrib>Liu, Jia</creatorcontrib><creatorcontrib>Lai, Baochang</creatorcontrib><creatorcontrib>Xiao, Lei</creatorcontrib><creatorcontrib>Wang, Nanping</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Meiqian</au><au>Zhang, Zihui</au><au>Xie, Xinya</au><au>Yao, Qinyu</au><au>Liu, Jia</au><au>Lai, Baochang</au><au>Xiao, Lei</au><au>Wang, Nanping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Xenobiotic pregnane X receptor promotes neointimal formation in balloon‐injured rat carotid arteries</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J Cell Physiol</addtitle><date>2019-04</date><risdate>2019</risdate><volume>234</volume><issue>4</issue><spage>4342</spage><epage>4351</epage><pages>4342-4351</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><abstract>Pregnane X receptor (PXR) is a member of nuclear receptor superfamily and responsible for the detoxification of xenobiotics. Recent studies demonstrated that PXR was also expressed in the vasculature and protected the vessels from endogenous and exogenous insults, thus representing a novel gatekeeper in vascular defense. In this study, we examined the potential function of PXR in the neointimal formation following vascular injury. In the rat carotid artery after balloon injury, overexpression of a constitutively active PXR increased the intima‐to‐media ratio in the injured region. PXR increased cell proliferation and migration in cultured rat aortic smooth muscle cells (SMCs) by inducing the expressions of cyclins (cyclin A, D1, and E) and cyclin‐dependent kinase 2. In addition, PXR increased the phosphorylation and activation of extracellular‐signal‐regulated kinase 1/2 (ERK1/2) and p38 mitogen‐activated protein kinase (MAPK). Inactivation of ERK1/2 and p38 MAPK pathways using selective inhibitors (U0126 and SB203580) abrogated PXR‐induced SMC proliferation and migration. Furthermore, cigarette smoke particles (CSP) activated PXR in SMCs. Knockdown of PXR by small interfering RNA suppressed the cell proliferation, migration, and activation of the MAPK pathways by CSP. These findings suggested a novel role for PXR in promoting SMC proliferation and migration, and neointimal hyperplasia. Therefore, PXR may be a potential therapeutic target for vascular disease related to xenobiotics such as cigarette smoking and other environmental pollutants.
Our findings suggested a novel role for pregnane X receptor (PXR) in promoting smooth muscle cell (SMC) proliferation and migration, and neointimal hyperplasia. In the rat carotid artery after balloon injury, overexpression of a constitutively active PXR increased the intima‐to‐media ratio in the injured region. PXR increased cell proliferation and migration in cultured rat aortic SMCs. Therefore, PXR may be a potential therapeutic target for vascular disease related to xenobiotics such as cigarette smoking and other environmental pollutants.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30132884</pmid><doi>10.1002/jcp.27215</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-8528-8132</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-9541 |
| ispartof | Journal of cellular physiology, 2019-04, Vol.234 (4), p.4342-4351 |
| issn | 0021-9541 1097-4652 |
| language | eng |
| recordid | cdi_proquest_journals_2162387132 |
| source | MEDLINE; Wiley Journals |
| subjects | Angioplasty, Balloon Animals Aorta Arteries Blood vessels Carotid arteries Carotid Arteries - metabolism Carotid Arteries - pathology Carotid artery Carotid Artery Injuries - etiology Carotid Artery Injuries - metabolism Carotid Artery Injuries - pathology Cell activation Cell growth Cell migration Cell Movement Cell Proliferation Cells, Cultured Cigarette smoke Cigarette smoking Cigarettes Cyclin A Cyclins - metabolism Deactivation Detoxification Disease Models, Animal Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism Hyperplasia Inactivation Injuries Kinases Male MAP kinase migration Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Muscles Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Neointima neointimal formation p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Pollutants pregnane X receptor (PXR) Pregnane X Receptor - agonists Pregnane X Receptor - metabolism proliferation Protein kinase Proteins Rats, Sprague-Dawley Ribonucleic acid RNA Rodents Signal Transduction siRNA Smoke Smoke - adverse effects Smooth muscle smooth muscle cell (SMC) Therapeutic applications Tobacco Products - adverse effects Vascular diseases Xenobiotics |
| title | Xenobiotic pregnane X receptor promotes neointimal formation in balloon‐injured rat carotid arteries |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T05%3A47%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Xenobiotic%20pregnane%20X%20receptor%20promotes%20neointimal%20formation%20in%20balloon%E2%80%90injured%20rat%20carotid%20arteries&rft.jtitle=Journal%20of%20cellular%20physiology&rft.au=Zhang,%20Meiqian&rft.date=2019-04&rft.volume=234&rft.issue=4&rft.spage=4342&rft.epage=4351&rft.pages=4342-4351&rft.issn=0021-9541&rft.eissn=1097-4652&rft_id=info:doi/10.1002/jcp.27215&rft_dat=%3Cproquest_cross%3E2162387132%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2162387132&rft_id=info:pmid/30132884&rfr_iscdi=true |