Enhanced Circulating Half-Life and Antitumor Activity of a Site-Specific Pegylated Interferon-[alpha] Protein Therapeutic

Recombinant interferon alpha-2 (IFN-α2) has proven useful for treating a variety of human cancers and viral diseases. IFN-α2 has a short circulating half-life in vivo, which necessitates daily or thrice weekly administration to patients. It is possible to extend the circulating half-life of IFN-α2 b...

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Veröffentlicht in:	Bioconjugate chemistry 2008-01, Vol.19 (1), p.299
Hauptverfasser:	Bell, Stacie J, Fam, Christine M, Chlipala, Elizabeth A, Carlson, Sharon J, Lee, Ji I, Rosendahl, Mary S, Doherty, Daniel H, Cox, George N
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Interferon Polyethylene glycol Proteins Tumors
Online-Zugang:	Volltext
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