Life-threatening hyperkalaemia following therapeutic barbiturate coma
To report the occurrence of life-threatening hyperkalaemia following treatment with therapeutic thiopentone coma. The neurosurgical intensive care units of Royal North Shore Hospital and Liverpool Hospital, Sydney, Australia. Three patients treated with theraputic thiopentone coma. One patient with...
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| Veröffentlicht in: | Intensive care medicine 2002-09, Vol.28 (9), p.1357-1360 |
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| container_title | Intensive care medicine |
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| creator | CAIRNS, Christopher J. S THOMAS, Benjamin FLETCHER, Stephen PARR, Michael J. A FINFER, Simon R |
| description | To report the occurrence of life-threatening hyperkalaemia following treatment with therapeutic thiopentone coma.
The neurosurgical intensive care units of Royal North Shore Hospital and Liverpool Hospital, Sydney, Australia.
Three patients treated with theraputic thiopentone coma. One patient with raised intracranial pressure secondary to a severe traumatic brain injury and two patients with refractory vasospasm secondary to subarachnoid haemorrhage. Two of the three patients developed hypokalaemia on starting thiopentone, which was resistant to potassium supplementation. All three patients developed severe hyperkalaemia during the recovery phase of coma. This was life-threatening in all three patients and fatal in one.
Severe hypokalaemia refractory to potassium therapy may occur during therapeutic thiopentone coma. Severe rebound hyperkalaemia may occur after cessation of thiopentone infusion. Protocols for the management of patients with therapeutic barbiturate coma should recognise this potentially serious complication. |
| doi_str_mv | 10.1007/s00134-002-1399-y |
| format | Article |
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The neurosurgical intensive care units of Royal North Shore Hospital and Liverpool Hospital, Sydney, Australia.
Three patients treated with theraputic thiopentone coma. One patient with raised intracranial pressure secondary to a severe traumatic brain injury and two patients with refractory vasospasm secondary to subarachnoid haemorrhage. Two of the three patients developed hypokalaemia on starting thiopentone, which was resistant to potassium supplementation. All three patients developed severe hyperkalaemia during the recovery phase of coma. This was life-threatening in all three patients and fatal in one.
Severe hypokalaemia refractory to potassium therapy may occur during therapeutic thiopentone coma. Severe rebound hyperkalaemia may occur after cessation of thiopentone infusion. Protocols for the management of patients with therapeutic barbiturate coma should recognise this potentially serious complication.</description><identifier>ISSN: 0342-4642</identifier><identifier>EISSN: 1432-1238</identifier><identifier>DOI: 10.1007/s00134-002-1399-y</identifier><identifier>PMID: 12209290</identifier><identifier>CODEN: ICMED9</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adult ; Australia ; Biological and medical sciences ; Brain Injuries - therapy ; Coma - chemically induced ; Critical Illness ; Drug toxicity and drugs side effects treatment ; Female ; Glasgow Coma Scale ; Humans ; Hyperkalemia - chemically induced ; Hyperkalemia - pathology ; Hypnotics and Sedatives - adverse effects ; Male ; Medical sciences ; Middle Aged ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Pharmacology. Drug treatments ; Subarachnoid Hemorrhage - therapy ; Thiopental - adverse effects ; Treatment Outcome ; Tropical medicine</subject><ispartof>Intensive care medicine, 2002-09, Vol.28 (9), p.1357-1360</ispartof><rights>2002 INIST-CNRS</rights><rights>Springer-Verlag 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-32368913a3c0d553630206b7f4060b41ff12cf388cefa16bcd5731fe56feeccf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27915,27916</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13919746$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12209290$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CAIRNS, Christopher J. S</creatorcontrib><creatorcontrib>THOMAS, Benjamin</creatorcontrib><creatorcontrib>FLETCHER, Stephen</creatorcontrib><creatorcontrib>PARR, Michael J. A</creatorcontrib><creatorcontrib>FINFER, Simon R</creatorcontrib><title>Life-threatening hyperkalaemia following therapeutic barbiturate coma</title><title>Intensive care medicine</title><addtitle>Intensive Care Med</addtitle><description>To report the occurrence of life-threatening hyperkalaemia following treatment with therapeutic thiopentone coma.
The neurosurgical intensive care units of Royal North Shore Hospital and Liverpool Hospital, Sydney, Australia.
Three patients treated with theraputic thiopentone coma. One patient with raised intracranial pressure secondary to a severe traumatic brain injury and two patients with refractory vasospasm secondary to subarachnoid haemorrhage. Two of the three patients developed hypokalaemia on starting thiopentone, which was resistant to potassium supplementation. All three patients developed severe hyperkalaemia during the recovery phase of coma. This was life-threatening in all three patients and fatal in one.
Severe hypokalaemia refractory to potassium therapy may occur during therapeutic thiopentone coma. Severe rebound hyperkalaemia may occur after cessation of thiopentone infusion. Protocols for the management of patients with therapeutic barbiturate coma should recognise this potentially serious complication.</description><subject>Adult</subject><subject>Australia</subject><subject>Biological and medical sciences</subject><subject>Brain Injuries - therapy</subject><subject>Coma - chemically induced</subject><subject>Critical Illness</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Glasgow Coma Scale</subject><subject>Humans</subject><subject>Hyperkalemia - chemically induced</subject><subject>Hyperkalemia - pathology</subject><subject>Hypnotics and Sedatives - adverse effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Pharmacology. Drug treatments</subject><subject>Subarachnoid Hemorrhage - therapy</subject><subject>Thiopental - adverse effects</subject><subject>Treatment Outcome</subject><subject>Tropical medicine</subject><issn>0342-4642</issn><issn>1432-1238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpFkE1LAzEQhoMotlZ_gBdZBI-rM0k2uzlKqR9Q8KLnkE0Tu3W_THaR_femtNDTMDPPOwMPIbcIjwiQPwUAZDwFoCkyKdPpjMyRs9hRVpyTOTBOUy44nZGrEHaRzkWGl2SGlIKkEuZkta6cTYett3qwbdV-J9upt_5H19o2lU5cV9fd334-bK3XvR2HyiSl9mU1jD5mEtM1-ppcOF0He3OsC_L1svpcvqXrj9f35fM6NSzjQ8ooE4VEppmBTZYxwYCCKHPHQUDJ0TmkxrGiMNZpFKXZZDlDZzPhrDVxsyD3h7u9735HGwa160bfxpeKokCZFQVGCA-Q8V0I3jrV-6rRflIIau9NHbyp6E3tvakpZu6Oh8eysZtT4igqAg9HQAeja-d1a6pw4phEmXPB_gGgvHYT</recordid><startdate>20020901</startdate><enddate>20020901</enddate><creator>CAIRNS, Christopher J. 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Drug treatments</topic><topic>Subarachnoid Hemorrhage - therapy</topic><topic>Thiopental - adverse effects</topic><topic>Treatment Outcome</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CAIRNS, Christopher J. S</creatorcontrib><creatorcontrib>THOMAS, Benjamin</creatorcontrib><creatorcontrib>FLETCHER, Stephen</creatorcontrib><creatorcontrib>PARR, Michael J. 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S</au><au>THOMAS, Benjamin</au><au>FLETCHER, Stephen</au><au>PARR, Michael J. A</au><au>FINFER, Simon R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Life-threatening hyperkalaemia following therapeutic barbiturate coma</atitle><jtitle>Intensive care medicine</jtitle><addtitle>Intensive Care Med</addtitle><date>2002-09-01</date><risdate>2002</risdate><volume>28</volume><issue>9</issue><spage>1357</spage><epage>1360</epage><pages>1357-1360</pages><issn>0342-4642</issn><eissn>1432-1238</eissn><coden>ICMED9</coden><abstract>To report the occurrence of life-threatening hyperkalaemia following treatment with therapeutic thiopentone coma.
The neurosurgical intensive care units of Royal North Shore Hospital and Liverpool Hospital, Sydney, Australia.
Three patients treated with theraputic thiopentone coma. One patient with raised intracranial pressure secondary to a severe traumatic brain injury and two patients with refractory vasospasm secondary to subarachnoid haemorrhage. Two of the three patients developed hypokalaemia on starting thiopentone, which was resistant to potassium supplementation. All three patients developed severe hyperkalaemia during the recovery phase of coma. This was life-threatening in all three patients and fatal in one.
Severe hypokalaemia refractory to potassium therapy may occur during therapeutic thiopentone coma. Severe rebound hyperkalaemia may occur after cessation of thiopentone infusion. Protocols for the management of patients with therapeutic barbiturate coma should recognise this potentially serious complication.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>12209290</pmid><doi>10.1007/s00134-002-1399-y</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Australia Biological and medical sciences Brain Injuries - therapy Coma - chemically induced Critical Illness Drug toxicity and drugs side effects treatment Female Glasgow Coma Scale Humans Hyperkalemia - chemically induced Hyperkalemia - pathology Hypnotics and Sedatives - adverse effects Male Medical sciences Middle Aged Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Subarachnoid Hemorrhage - therapy Thiopental - adverse effects Treatment Outcome Tropical medicine |
| title | Life-threatening hyperkalaemia following therapeutic barbiturate coma |
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