Natural killer cell function predicts severe infection in kidney transplant recipients

The aim of this study was to determine if natural killer cell number (CD3−/CD16±/CD56±) and cytotoxic killing function predicts severity and frequency of infection in kidney transplant recipients. A cohort of 168 kidney transplant recipients with stable graft function underwent assessment of natural...

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Veröffentlicht in:	American journal of transplantation 2019-01, Vol.19 (1), p.166-177
Hauptverfasser:	Dendle, Claire, Gan, Poh‐Yi, Polkinghorne, Kevan R., Ngui, James, Stuart, Rhonda L., Kanellis, John, Thursky, Karin, Mulley, William R., Holdsworth, Stephen
Format:	Artikel
Sprache:	eng
Schlagworte:	Area Under Curve CD16 antigen CD3 antigen CD56 antigen Cell number clinical research/practice Cytomegalovirus Cytomegalovirus (CMV) Cytomegalovirus Infections - blood Cytomegalovirus Infections - complications Cytotoxicity Female Health risk assessment Humans immunosuppression/immune modulation Immunosuppressive Agents - pharmacology Incidence infection and infectious agents infection and infectious agents – bacterial infection and infectious agents – viral Infections infectious disease kidney (allograft) function/dysfunction Kidney Failure, Chronic - complications Kidney Failure, Chronic - surgery Kidney transplantation Kidney Transplantation - adverse effects kidney transplantation/nephrology Kidney transplants Killer Cells, Natural - cytology Male Middle Aged Mycophenolic acid natural killer (NK) cells/NK receptors Natural killer cells Postoperative Complications Prospective Studies Regression Analysis Risk ROC Curve translational research/science Transplant Recipients
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