VCAM-1^sup +^ macrophages guide the homing of HSPCs to a vascular niche

Haematopoietic stem and progenitor cells (HSPCs) give rise to all blood lineages that support the entire lifespan of vertebrates. After HSPCs emerge from endothelial cells within the developing dorsal aorta, homing allows the nascent cells to anchor in their niches for further expansion and differen...

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Veröffentlicht in:	Nature (London) 2018-12, Vol.564 (7734), p.1
Hauptverfasser:	Li, Dantong, Xue, Wenzhi, Li, Mei, Dong, Mei, Wang, Jianwei, Wang, Xianda, Li, Xiyue, Chen, Kai, Zhang, Wenjuan, Wu, Shuang, Zhang, Yingqi, Gao, Lei, Chen, Yujie, Chen, Jianfeng, Zhou, Bo O, Zhou, Yi, Yao, Xuebiao, Li, Lin, Wu, Dianqing, Pan, Weijun
Format:	Artikel
Sprache:	eng
Schlagworte:	Aorta Architecture Blood vessels Capillaries Cell cycle Cells (biology) Cloning Coronary vessels CRISPR Defects Endothelial cells Endothelium Fetuses Gene expression Hematopoietic stem cells Hemopoiesis Homing Labeling Life span Liver Macrophages Mammals Microenvironments Mutation Progenitor cells Proteins Retention Stromal cells Transcription factors Vascular cell adhesion molecule 1 Vertebrates Zebrafish
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