VCAM-1^sup +^ macrophages guide the homing of HSPCs to a vascular niche
Haematopoietic stem and progenitor cells (HSPCs) give rise to all blood lineages that support the entire lifespan of vertebrates. After HSPCs emerge from endothelial cells within the developing dorsal aorta, homing allows the nascent cells to anchor in their niches for further expansion and differen...
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| Veröffentlicht in: | Nature (London) 2018-12, Vol.564 (7734), p.1 |
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| creator | Li, Dantong Xue, Wenzhi Li, Mei Dong, Mei Wang, Jianwei Wang, Xianda Li, Xiyue Chen, Kai Zhang, Wenjuan Wu, Shuang Zhang, Yingqi Gao, Lei Chen, Yujie Chen, Jianfeng Zhou, Bo O Zhou, Yi Yao, Xuebiao Li, Lin Wu, Dianqing Pan, Weijun |
| description | Haematopoietic stem and progenitor cells (HSPCs) give rise to all blood lineages that support the entire lifespan of vertebrates. After HSPCs emerge from endothelial cells within the developing dorsal aorta, homing allows the nascent cells to anchor in their niches for further expansion and differentiation. Unique niche microenvironments, composed of various blood vessels as units of microcirculation and other niche components such as stromal cells, regulate this process. However, the detailed architecture of the microenvironment and the mechanism for the regulation of HSPC homing remain unclear. Here, using advanced live imaging and a cell-labelling system, we perform high-resolution analyses of the HSPC homing in caudal haematopoietic tissue of zebrafish (equivalent to the fetal liver in mammals), and reveal the role of the vascular architecture in the regulation of HSPC retention. We identify a VCAM-1+ macrophage-like niche cell population that patrols the inner surface of the venous plexus, interacts with HSPCs in an ITGA4-dependent manner, and directs HSPC retention. These cells, named 'usher cells', together with caudal venous capillaries and plexus, define retention hotspots within the homing microenvironment. Thus, the study provides insights into the mechanism of HSPC homing and reveals the essential role of a VCAM-1+ macrophage population with patrolling behaviour in HSPC retention. |
| doi_str_mv | 10.1038/s41586-018-0709-7 |
| format | Article |
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After HSPCs emerge from endothelial cells within the developing dorsal aorta, homing allows the nascent cells to anchor in their niches for further expansion and differentiation. Unique niche microenvironments, composed of various blood vessels as units of microcirculation and other niche components such as stromal cells, regulate this process. However, the detailed architecture of the microenvironment and the mechanism for the regulation of HSPC homing remain unclear. Here, using advanced live imaging and a cell-labelling system, we perform high-resolution analyses of the HSPC homing in caudal haematopoietic tissue of zebrafish (equivalent to the fetal liver in mammals), and reveal the role of the vascular architecture in the regulation of HSPC retention. We identify a VCAM-1+ macrophage-like niche cell population that patrols the inner surface of the venous plexus, interacts with HSPCs in an ITGA4-dependent manner, and directs HSPC retention. These cells, named 'usher cells', together with caudal venous capillaries and plexus, define retention hotspots within the homing microenvironment. Thus, the study provides insights into the mechanism of HSPC homing and reveals the essential role of a VCAM-1+ macrophage population with patrolling behaviour in HSPC retention.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/s41586-018-0709-7</identifier><language>eng</language><publisher>London: Nature Publishing Group</publisher><subject>Aorta ; Architecture ; Blood vessels ; Capillaries ; Cell cycle ; Cells (biology) ; Cloning ; Coronary vessels ; CRISPR ; Defects ; Endothelial cells ; Endothelium ; Fetuses ; Gene expression ; Hematopoietic stem cells ; Hemopoiesis ; Homing ; Labeling ; Life span ; Liver ; Macrophages ; Mammals ; Microenvironments ; Mutation ; Progenitor cells ; Proteins ; Retention ; Stromal cells ; Transcription factors ; Vascular cell adhesion molecule 1 ; Vertebrates ; Zebrafish</subject><ispartof>Nature (London), 2018-12, Vol.564 (7734), p.1</ispartof><rights>Copyright Nature Publishing Group Dec 6, 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids></links><search><creatorcontrib>Li, Dantong</creatorcontrib><creatorcontrib>Xue, Wenzhi</creatorcontrib><creatorcontrib>Li, Mei</creatorcontrib><creatorcontrib>Dong, Mei</creatorcontrib><creatorcontrib>Wang, Jianwei</creatorcontrib><creatorcontrib>Wang, Xianda</creatorcontrib><creatorcontrib>Li, Xiyue</creatorcontrib><creatorcontrib>Chen, Kai</creatorcontrib><creatorcontrib>Zhang, Wenjuan</creatorcontrib><creatorcontrib>Wu, Shuang</creatorcontrib><creatorcontrib>Zhang, Yingqi</creatorcontrib><creatorcontrib>Gao, Lei</creatorcontrib><creatorcontrib>Chen, Yujie</creatorcontrib><creatorcontrib>Chen, Jianfeng</creatorcontrib><creatorcontrib>Zhou, Bo O</creatorcontrib><creatorcontrib>Zhou, Yi</creatorcontrib><creatorcontrib>Yao, Xuebiao</creatorcontrib><creatorcontrib>Li, Lin</creatorcontrib><creatorcontrib>Wu, Dianqing</creatorcontrib><creatorcontrib>Pan, Weijun</creatorcontrib><title>VCAM-1^sup +^ macrophages guide the homing of HSPCs to a vascular niche</title><title>Nature (London)</title><description>Haematopoietic stem and progenitor cells (HSPCs) give rise to all blood lineages that support the entire lifespan of vertebrates. After HSPCs emerge from endothelial cells within the developing dorsal aorta, homing allows the nascent cells to anchor in their niches for further expansion and differentiation. Unique niche microenvironments, composed of various blood vessels as units of microcirculation and other niche components such as stromal cells, regulate this process. However, the detailed architecture of the microenvironment and the mechanism for the regulation of HSPC homing remain unclear. Here, using advanced live imaging and a cell-labelling system, we perform high-resolution analyses of the HSPC homing in caudal haematopoietic tissue of zebrafish (equivalent to the fetal liver in mammals), and reveal the role of the vascular architecture in the regulation of HSPC retention. We identify a VCAM-1+ macrophage-like niche cell population that patrols the inner surface of the venous plexus, interacts with HSPCs in an ITGA4-dependent manner, and directs HSPC retention. These cells, named 'usher cells', together with caudal venous capillaries and plexus, define retention hotspots within the homing microenvironment. Thus, the study provides insights into the mechanism of HSPC homing and reveals the essential role of a VCAM-1+ macrophage population with patrolling behaviour in HSPC retention.</description><subject>Aorta</subject><subject>Architecture</subject><subject>Blood vessels</subject><subject>Capillaries</subject><subject>Cell cycle</subject><subject>Cells (biology)</subject><subject>Cloning</subject><subject>Coronary vessels</subject><subject>CRISPR</subject><subject>Defects</subject><subject>Endothelial cells</subject><subject>Endothelium</subject><subject>Fetuses</subject><subject>Gene expression</subject><subject>Hematopoietic stem cells</subject><subject>Hemopoiesis</subject><subject>Homing</subject><subject>Labeling</subject><subject>Life span</subject><subject>Liver</subject><subject>Macrophages</subject><subject>Mammals</subject><subject>Microenvironments</subject><subject>Mutation</subject><subject>Progenitor cells</subject><subject>Proteins</subject><subject>Retention</subject><subject>Stromal cells</subject><subject>Transcription factors</subject><subject>Vascular cell adhesion molecule 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Jianfeng</au><au>Zhou, Bo O</au><au>Zhou, Yi</au><au>Yao, Xuebiao</au><au>Li, Lin</au><au>Wu, Dianqing</au><au>Pan, Weijun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>VCAM-1^sup +^ macrophages guide the homing of HSPCs to a vascular niche</atitle><jtitle>Nature (London)</jtitle><date>2018-12-06</date><risdate>2018</risdate><volume>564</volume><issue>7734</issue><spage>1</spage><pages>1-</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>Haematopoietic stem and progenitor cells (HSPCs) give rise to all blood lineages that support the entire lifespan of vertebrates. After HSPCs emerge from endothelial cells within the developing dorsal aorta, homing allows the nascent cells to anchor in their niches for further expansion and differentiation. Unique niche microenvironments, composed of various blood vessels as units of microcirculation and other niche components such as stromal cells, regulate this process. However, the detailed architecture of the microenvironment and the mechanism for the regulation of HSPC homing remain unclear. Here, using advanced live imaging and a cell-labelling system, we perform high-resolution analyses of the HSPC homing in caudal haematopoietic tissue of zebrafish (equivalent to the fetal liver in mammals), and reveal the role of the vascular architecture in the regulation of HSPC retention. We identify a VCAM-1+ macrophage-like niche cell population that patrols the inner surface of the venous plexus, interacts with HSPCs in an ITGA4-dependent manner, and directs HSPC retention. These cells, named 'usher cells', together with caudal venous capillaries and plexus, define retention hotspots within the homing microenvironment. Thus, the study provides insights into the mechanism of HSPC homing and reveals the essential role of a VCAM-1+ macrophage population with patrolling behaviour in HSPC retention.</abstract><cop>London</cop><pub>Nature Publishing Group</pub><doi>10.1038/s41586-018-0709-7</doi></addata></record> |
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| source | Nature; Alma/SFX Local Collection |
| subjects | Aorta Architecture Blood vessels Capillaries Cell cycle Cells (biology) Cloning Coronary vessels CRISPR Defects Endothelial cells Endothelium Fetuses Gene expression Hematopoietic stem cells Hemopoiesis Homing Labeling Life span Liver Macrophages Mammals Microenvironments Mutation Progenitor cells Proteins Retention Stromal cells Transcription factors Vascular cell adhesion molecule 1 Vertebrates Zebrafish |
| title | VCAM-1^sup +^ macrophages guide the homing of HSPCs to a vascular niche |
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