Design of oligonucleotide-capped mesoporous silica nanoparticles for the detection of miRNA-145 by duplex and triplex formation

•A new biosensor for the detection of miRNA-145 has been developed.•The system consists on a gated material capped with several oligonucleotide probes.•The system has shown high sensitivity, selectivity and rapidity.•The method was successfully applied in competitive serum samples. The development o...

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Veröffentlicht in:	Sensors and actuators. B, Chemical Chemical, 2018-12, Vol.277, p.598-603
Hauptverfasser:	Ribes, Àngela, Santiago-Felipe, Sara, Aviñó, Anna, Candela-Noguera, Vicente, Eritja, Ramón, Sancenón, Félix, Martínez-Máñez, Ramón, Aznar, Elena
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical materials Biosensor Biosensors Deoxyribonucleic acid Diagnostic systems DNA Fluorescence Mesoporous silica materials miRNA-145 Molecular gates Nanoparticles Oligonucleotides Rhodamine Ribonucleic acid RNA Silica Silicon dioxide triplex
Online-Zugang:	Volltext
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