Atorvastatin attenuates paraquat poisoning-induced epithelial-mesenchymal transition via downregulating hypoxia-inducible factor-1 alpha

This study investigated the effects of atorvastatin (ATS) on the paraquat (PQ)-induced epithelial-mesenchymal transition (EMT) and the potential mechanism through hypoxia-inducible factor-1 alpha (HIF-1α). Sprague–Dawley (SD) rats were randomly divided into a control group (n = 5), PQ group (n = 20)...

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Veröffentlicht in:	Life sciences (1973) 2018-11, Vol.213, p.126-133
Hauptverfasser:	Du, Jiang, Zhu, Yong, Meng, Xiaoxiao, Xie, Hui, Wang, Jinfeng, Zhou, Zhigang, Wang, Ruilan
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Animals Atorvastatin Atorvastatin - metabolism Atorvastatin - pharmacology Attenuation Cadherins - metabolism Catenin Cell culture Cell Line Cell lines Chemical compounds E-cadherin Epithelial-mesenchymal transition Epithelial-Mesenchymal Transition - drug effects Fibrosis Gene expression Humans Hypoxia Hypoxia-inducible factor Hypoxia-inducible factor 1 Hypoxia-Inducible Factor 1 - drug effects Hypoxia-Inducible Factor 1 - metabolism Hypoxia-Inducible Factor 1, alpha Subunit - drug effects Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-inducible factor 1a Hypoxia-inducible factors Lung - metabolism Lung diseases Lung Injury - drug therapy Lung Injury - metabolism Male Markers Mesenchyme Paraquat Paraquat - adverse effects Pharmacology Poisoning Pulmonary fibrosis Pulmonary Fibrosis - drug therapy Pulmonary Fibrosis - metabolism Rats Rats, Sprague-Dawley Signal Transduction - drug effects Statins Toxicity Vimentin Zonula occludens-1 protein Zonula Occludens-1 Protein - metabolism
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