Chronic Cigarette Smoke Exposure Subdues PP2A Activity by Enhancing Expression of the Oncogene CIP2A

Phosphatase activity of the major serine threonine phosphatase, protein phosphatase 2A (PP2A), is blunted in the airways of individuals with chronic obstructive pulmonary disease (COPD), which results in heightened inflammation and proteolytic responses. The objective of this study was to investigat...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2018-12, Vol.59 (6), p.695-705
Hauptverfasser:	Nath, Sridesh, Ohlmeyer, Michael, Salathe, Matthias A, Poon, Justin, Baumlin, Nathalie, Foronjy, Robert F, Geraghty, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animal models Animals Autoantigens - metabolism Cancer Cell culture Cell growth Cells, Cultured Chronic obstructive pulmonary disease Cigarette smoke Cigarette Smoking - adverse effects Cigarettes Environmental Exposure - adverse effects Fibroblast growth factor 2 Gene Expression Regulation, Neoplastic - drug effects Growth factors Humans Inflammation Intracellular Signaling Peptides and Proteins Kinases Lung diseases Lungs Membrane Proteins - metabolism Mice Mice, Inbred C57BL MicroRNAs Obstructive lung disease Oncogene Proteins - metabolism Oncogenes Phosphatase Phosphoprotein phosphatase Phosphorylation Protein phosphatase Protein Phosphatase 2 - metabolism Protein-serine/threonine phosphatase Proteins Proteolysis Pulmonary Disease, Chronic Obstructive - etiology Pulmonary Disease, Chronic Obstructive - metabolism Pulmonary Disease, Chronic Obstructive - pathology Respiratory function Ribonucleic acid RNA RNA polymerase RNA-mediated interference Serine Smoking Threonine phosphatase Tobacco smoke
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