Anti-biofouling therapeutic nanoparticles with removable shell and highly efficient internalization by cancer cells

Cationic gelatin nanoparticles ((+)nGNPs) were prepared by in situ polymerization upon the surfaces of monodispersed gelatin nanoparticles (GNPs) using N-(3-Aminopropyl)methacrylamide (APm) as monomer, which were then decorated with doxorubicin terminated poly(2-methylacryloyloxyethyl phosphorylchol...

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Veröffentlicht in:	Biomaterials science 2019-01, Vol.7 (1), p.336-346
Hauptverfasser:	Chen, Dong, Jiang, Huangyong, Guo, Dongbo, Yasen, Wumaier, Ao, Junping, Su, Yue, Pan, Dongsheng, Jin, Xin, Zhu, Xinyuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biofouling Cancer Cancer therapies Cationic polymerization Conjugation Doxorubicin Drug delivery systems Electropositivity Gelatin Hydrazones Methacrylamide Nanoparticles Phosphorylcholine Protein adsorption Proteins Therapy Toxicity
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