Antiinflammatory peptides: current knowledge and promising prospects

Background Inflammation is part of the regular host reaction to injury or infection caused by toxic factors, pathogens, damaged cells, irritants, and allergens. Antiinflammatory peptides (AIPs) are present in all living organisms, and many peptides from herbal, mammalian, bacterial, and marine origi...

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Veröffentlicht in:Inflammation research 2019-02, Vol.68 (2), p.125-145
Hauptverfasser: Dadar, Maryam, Shahali, Youcef, Chakraborty, Sandip, Prasad, Minakshi, Tahoori, Fatemeh, Tiwari, Ruchi, Dhama, Kuldeep
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container_end_page 145
container_issue 2
container_start_page 125
container_title Inflammation research
container_volume 68
creator Dadar, Maryam
Shahali, Youcef
Chakraborty, Sandip
Prasad, Minakshi
Tahoori, Fatemeh
Tiwari, Ruchi
Dhama, Kuldeep
description Background Inflammation is part of the regular host reaction to injury or infection caused by toxic factors, pathogens, damaged cells, irritants, and allergens. Antiinflammatory peptides (AIPs) are present in all living organisms, and many peptides from herbal, mammalian, bacterial, and marine origins have been shown to have antimicrobial and/or antiinflammatory properties. Methods In this study, we investigated the effects of antiinflammatory peptides on inflammation, and highlighted the underlying mechanisms responsible for these effects. Results In multicellular organisms, including humans, AIPs constitute an essential part of their immune system. In addition, numerous natural and synthetic AIPs are effective immunomodulators and can interfere with signal transduction pathways involved in inflammatory cytokine expression. Among them, some peptides such as antiflammin, N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP), and those derived from velvet antler proteins, bee venom, horse fly salivary gland, and bovine β-casein have received considerable attention over the past few years. Conclusion This article presents an overview on the major properties and mechanisms of action associated with AIPs as immunomodulatory, chemotactic, antioxidant, and antimicrobial agents. In addition, the results of various studies dealing with effects of AIPs on numerous classical models of inflammation are reviewed and discussed.
doi_str_mv 10.1007/s00011-018-1208-x
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Antiinflammatory peptides (AIPs) are present in all living organisms, and many peptides from herbal, mammalian, bacterial, and marine origins have been shown to have antimicrobial and/or antiinflammatory properties. Methods In this study, we investigated the effects of antiinflammatory peptides on inflammation, and highlighted the underlying mechanisms responsible for these effects. Results In multicellular organisms, including humans, AIPs constitute an essential part of their immune system. In addition, numerous natural and synthetic AIPs are effective immunomodulators and can interfere with signal transduction pathways involved in inflammatory cytokine expression. Among them, some peptides such as antiflammin, N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP), and those derived from velvet antler proteins, bee venom, horse fly salivary gland, and bovine β-casein have received considerable attention over the past few years. Conclusion This article presents an overview on the major properties and mechanisms of action associated with AIPs as immunomodulatory, chemotactic, antioxidant, and antimicrobial agents. In addition, the results of various studies dealing with effects of AIPs on numerous classical models of inflammation are reviewed and discussed.</description><identifier>ISSN: 1023-3830</identifier><identifier>EISSN: 1420-908X</identifier><identifier>DOI: 10.1007/s00011-018-1208-x</identifier><identifier>PMID: 30560372</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Allergens ; Allergology ; Antiinfectives and antibacterials ; Antimicrobial agents ; Antioxidants ; Biomedical and Life Sciences ; Biomedicine ; Casein ; Dermatology ; Immune system ; Immunology ; Immunomodulation ; Immunomodulators ; Inflammation ; Neurology ; Peptides ; Pharmacology/Toxicology ; Proline ; Proteins ; Reagents ; Review ; Rheumatology ; Salivary gland ; Salivary glands ; Signal transduction ; Venom</subject><ispartof>Inflammation research, 2019-02, Vol.68 (2), p.125-145</ispartof><rights>Springer Nature Switzerland AG 2018</rights><rights>Inflammation Research is a copyright of Springer, (2018). 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Among them, some peptides such as antiflammin, N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP), and those derived from velvet antler proteins, bee venom, horse fly salivary gland, and bovine β-casein have received considerable attention over the past few years. Conclusion This article presents an overview on the major properties and mechanisms of action associated with AIPs as immunomodulatory, chemotactic, antioxidant, and antimicrobial agents. 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In addition, numerous natural and synthetic AIPs are effective immunomodulators and can interfere with signal transduction pathways involved in inflammatory cytokine expression. Among them, some peptides such as antiflammin, N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP), and those derived from velvet antler proteins, bee venom, horse fly salivary gland, and bovine β-casein have received considerable attention over the past few years. Conclusion This article presents an overview on the major properties and mechanisms of action associated with AIPs as immunomodulatory, chemotactic, antioxidant, and antimicrobial agents. In addition, the results of various studies dealing with effects of AIPs on numerous classical models of inflammation are reviewed and discussed.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>30560372</pmid><doi>10.1007/s00011-018-1208-x</doi><tpages>21</tpages></addata></record>
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subjects Allergens
Allergology
Antiinfectives and antibacterials
Antimicrobial agents
Antioxidants
Biomedical and Life Sciences
Biomedicine
Casein
Dermatology
Immune system
Immunology
Immunomodulation
Immunomodulators
Inflammation
Neurology
Peptides
Pharmacology/Toxicology
Proline
Proteins
Reagents
Review
Rheumatology
Salivary gland
Salivary glands
Signal transduction
Venom
title Antiinflammatory peptides: current knowledge and promising prospects
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