Accuracy of urine dipsticks, 2-h and 12-h urine collections for protein measurement as compared with the 24-h collection
Summary The presence of protein in hypertensive disorders of pregnancy is a sign of a worsening condition and thus requires early intervention to prevent adverse consequences. Accurate assessment of proteinuria in patients with pre-eclampsia will ensure prompt and timely intervention to reduce or pr...
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Veröffentlicht in: | Journal of obstetrics and gynaecology 2008-07, Vol.28 (5), p.496-500 |
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creator | Abebe, J. Eigbefoh, J. Isabu, P. Okogbenin, S. Eifediyi, R. Okusanya, B. |
description | Summary
The presence of protein in hypertensive disorders of pregnancy is a sign of a worsening condition and thus requires early intervention to prevent adverse consequences. Accurate assessment of proteinuria in patients with pre-eclampsia will ensure prompt and timely intervention to reduce or prevent the maternal and perinatal morbidity and mortality associated with pre-eclampsia. This study compared the reliability and validity of the more rapid diagnostic tests, such as the dipstick, 2-h and 12-h protein estimations with the 24-h protein. The result of the dipstick, 2-h and 12-h urine were also compared with the 24-h urine results using confidence interval (CI) for proportions with a value of p < 0.05 considered significant (CI 95%). When compared with the gold standard, there was a high degree of correlation between the 2-h (p = 0.244, CI 95%) and 12-h (p < 0.0255, CI 95%) with the 24-h sample in the quantification of proteinuria in women with pre-eclampsia. The most sensitive and specific test was the 12-h protein estimation, (89%) and (93%), respectively. The least sensitive and specific test was the dipstick test; (81%) and (47%), respectively. The 12-h protein estimation test had the highest positive predictive value (84%). The 12-h protein test also had the lowest false positive rate (12%) and false negative rates (11%), respectively. The most accurate test was the 12-h protein estimation (88%). The dipstick tests were however much cheaper and the results were faster. It is recommended that routine rapid quantisation of proteinuria in patients with pre-eclampsia be done using either the 2-h or 12-h urine sample. |
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The presence of protein in hypertensive disorders of pregnancy is a sign of a worsening condition and thus requires early intervention to prevent adverse consequences. Accurate assessment of proteinuria in patients with pre-eclampsia will ensure prompt and timely intervention to reduce or prevent the maternal and perinatal morbidity and mortality associated with pre-eclampsia. This study compared the reliability and validity of the more rapid diagnostic tests, such as the dipstick, 2-h and 12-h protein estimations with the 24-h protein. The result of the dipstick, 2-h and 12-h urine were also compared with the 24-h urine results using confidence interval (CI) for proportions with a value of p < 0.05 considered significant (CI 95%). When compared with the gold standard, there was a high degree of correlation between the 2-h (p = 0.244, CI 95%) and 12-h (p < 0.0255, CI 95%) with the 24-h sample in the quantification of proteinuria in women with pre-eclampsia. The most sensitive and specific test was the 12-h protein estimation, (89%) and (93%), respectively. The least sensitive and specific test was the dipstick test; (81%) and (47%), respectively. The 12-h protein estimation test had the highest positive predictive value (84%). The 12-h protein test also had the lowest false positive rate (12%) and false negative rates (11%), respectively. The most accurate test was the 12-h protein estimation (88%). The dipstick tests were however much cheaper and the results were faster. It is recommended that routine rapid quantisation of proteinuria in patients with pre-eclampsia be done using either the 2-h or 12-h urine sample.</description><identifier>ISSN: 0144-3615</identifier><identifier>EISSN: 1364-6893</identifier><identifier>DOI: 10.1080/01443610802196880</identifier><identifier>PMID: 18850422</identifier><identifier>CODEN: JOGYDW</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>24-h urine ; Adult ; diagnosis ; Female ; Humans ; Medical disorders ; Medical procedures ; Obstetrics ; Pre-eclampsia ; Pre-Eclampsia - diagnosis ; Pre-Eclampsia - urine ; Pregnancy ; Proteins ; proteinuria ; Proteinuria - urine ; Reagent Strips ; Reproducibility of Results ; Sensitivity and Specificity ; Time Factors ; Urinalysis ; Urine ; urine dipstick</subject><ispartof>Journal of obstetrics and gynaecology, 2008-07, Vol.28 (5), p.496-500</ispartof><rights>2008 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2008</rights><rights>Copyright Taylor & Francis Ltd. Jul 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-d88b04b43f9c9c44e1cbfa38112140cd6854b772514e620768bca2d59c0f08823</citedby><cites>FETCH-LOGICAL-c431t-d88b04b43f9c9c44e1cbfa38112140cd6854b772514e620768bca2d59c0f08823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/01443610802196880$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/01443610802196880$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,59647,60436,61221,61402</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18850422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abebe, J.</creatorcontrib><creatorcontrib>Eigbefoh, J.</creatorcontrib><creatorcontrib>Isabu, P.</creatorcontrib><creatorcontrib>Okogbenin, S.</creatorcontrib><creatorcontrib>Eifediyi, R.</creatorcontrib><creatorcontrib>Okusanya, B.</creatorcontrib><title>Accuracy of urine dipsticks, 2-h and 12-h urine collections for protein measurement as compared with the 24-h collection</title><title>Journal of obstetrics and gynaecology</title><addtitle>J Obstet Gynaecol</addtitle><description>Summary
The presence of protein in hypertensive disorders of pregnancy is a sign of a worsening condition and thus requires early intervention to prevent adverse consequences. Accurate assessment of proteinuria in patients with pre-eclampsia will ensure prompt and timely intervention to reduce or prevent the maternal and perinatal morbidity and mortality associated with pre-eclampsia. This study compared the reliability and validity of the more rapid diagnostic tests, such as the dipstick, 2-h and 12-h protein estimations with the 24-h protein. The result of the dipstick, 2-h and 12-h urine were also compared with the 24-h urine results using confidence interval (CI) for proportions with a value of p < 0.05 considered significant (CI 95%). When compared with the gold standard, there was a high degree of correlation between the 2-h (p = 0.244, CI 95%) and 12-h (p < 0.0255, CI 95%) with the 24-h sample in the quantification of proteinuria in women with pre-eclampsia. The most sensitive and specific test was the 12-h protein estimation, (89%) and (93%), respectively. The least sensitive and specific test was the dipstick test; (81%) and (47%), respectively. The 12-h protein estimation test had the highest positive predictive value (84%). The 12-h protein test also had the lowest false positive rate (12%) and false negative rates (11%), respectively. The most accurate test was the 12-h protein estimation (88%). The dipstick tests were however much cheaper and the results were faster. It is recommended that routine rapid quantisation of proteinuria in patients with pre-eclampsia be done using either the 2-h or 12-h urine sample.</description><subject>24-h urine</subject><subject>Adult</subject><subject>diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>Medical disorders</subject><subject>Medical procedures</subject><subject>Obstetrics</subject><subject>Pre-eclampsia</subject><subject>Pre-Eclampsia - diagnosis</subject><subject>Pre-Eclampsia - urine</subject><subject>Pregnancy</subject><subject>Proteins</subject><subject>proteinuria</subject><subject>Proteinuria - urine</subject><subject>Reagent Strips</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Time Factors</subject><subject>Urinalysis</subject><subject>Urine</subject><subject>urine dipstick</subject><issn>0144-3615</issn><issn>1364-6893</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhoMo7rj6A7xI8ODJ1lS-Oo17WRa_YMGLnkM6naazdidjkmadf2-aGRhU9FQF9bwvVfUi9BzIGyCKvCXAOZNbS6GTSpEHaAdM8kaqjj1Eu23eVEBcoCc53xFCgAj-GF2AUoJwSnfo57W1azL2gOOI1-SDw4Pf5-Lt9_wa02bCJgwYtuY4tXGenS0-hozHmPA-xeJ8wIszeU1ucaFgkyu27E1yA773ZcJlcpjy6nFWP0WPRjNn9-xUL9G3D--_3nxqbr98_HxzfdtYzqA0g1I94T1nY2c7y7kD24-GKQAKnNhBKsH7tqUCuJOUtFL11tBBdJaMRCnKLtGro29d9MfqctGLz9bNswkurlnLTgoQsq3gyz_Au7imUHfTFERLWddtbnCEbIo5JzfqffKLSQcNRG9B6L8yqZoXJ-O1X9xwVpxCqMDVEfChfnQx9zHNgy7mMMc0JhOsz5r9z__db_LJmblMtn7_fMG_1b8AgjiqjA</recordid><startdate>200807</startdate><enddate>200807</enddate><creator>Abebe, J.</creator><creator>Eigbefoh, J.</creator><creator>Isabu, P.</creator><creator>Okogbenin, S.</creator><creator>Eifediyi, R.</creator><creator>Okusanya, B.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200807</creationdate><title>Accuracy of urine dipsticks, 2-h and 12-h urine collections for protein measurement as compared with the 24-h collection</title><author>Abebe, J. ; Eigbefoh, J. ; Isabu, P. ; Okogbenin, S. ; Eifediyi, R. ; Okusanya, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-d88b04b43f9c9c44e1cbfa38112140cd6854b772514e620768bca2d59c0f08823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>24-h urine</topic><topic>Adult</topic><topic>diagnosis</topic><topic>Female</topic><topic>Humans</topic><topic>Medical disorders</topic><topic>Medical procedures</topic><topic>Obstetrics</topic><topic>Pre-eclampsia</topic><topic>Pre-Eclampsia - diagnosis</topic><topic>Pre-Eclampsia - urine</topic><topic>Pregnancy</topic><topic>Proteins</topic><topic>proteinuria</topic><topic>Proteinuria - urine</topic><topic>Reagent Strips</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Time Factors</topic><topic>Urinalysis</topic><topic>Urine</topic><topic>urine dipstick</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abebe, J.</creatorcontrib><creatorcontrib>Eigbefoh, J.</creatorcontrib><creatorcontrib>Isabu, P.</creatorcontrib><creatorcontrib>Okogbenin, S.</creatorcontrib><creatorcontrib>Eifediyi, R.</creatorcontrib><creatorcontrib>Okusanya, B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abebe, J.</au><au>Eigbefoh, J.</au><au>Isabu, P.</au><au>Okogbenin, S.</au><au>Eifediyi, R.</au><au>Okusanya, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Accuracy of urine dipsticks, 2-h and 12-h urine collections for protein measurement as compared with the 24-h collection</atitle><jtitle>Journal of obstetrics and gynaecology</jtitle><addtitle>J Obstet Gynaecol</addtitle><date>2008-07</date><risdate>2008</risdate><volume>28</volume><issue>5</issue><spage>496</spage><epage>500</epage><pages>496-500</pages><issn>0144-3615</issn><eissn>1364-6893</eissn><coden>JOGYDW</coden><abstract>Summary
The presence of protein in hypertensive disorders of pregnancy is a sign of a worsening condition and thus requires early intervention to prevent adverse consequences. Accurate assessment of proteinuria in patients with pre-eclampsia will ensure prompt and timely intervention to reduce or prevent the maternal and perinatal morbidity and mortality associated with pre-eclampsia. This study compared the reliability and validity of the more rapid diagnostic tests, such as the dipstick, 2-h and 12-h protein estimations with the 24-h protein. The result of the dipstick, 2-h and 12-h urine were also compared with the 24-h urine results using confidence interval (CI) for proportions with a value of p < 0.05 considered significant (CI 95%). When compared with the gold standard, there was a high degree of correlation between the 2-h (p = 0.244, CI 95%) and 12-h (p < 0.0255, CI 95%) with the 24-h sample in the quantification of proteinuria in women with pre-eclampsia. The most sensitive and specific test was the 12-h protein estimation, (89%) and (93%), respectively. The least sensitive and specific test was the dipstick test; (81%) and (47%), respectively. The 12-h protein estimation test had the highest positive predictive value (84%). The 12-h protein test also had the lowest false positive rate (12%) and false negative rates (11%), respectively. The most accurate test was the 12-h protein estimation (88%). The dipstick tests were however much cheaper and the results were faster. It is recommended that routine rapid quantisation of proteinuria in patients with pre-eclampsia be done using either the 2-h or 12-h urine sample.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>18850422</pmid><doi>10.1080/01443610802196880</doi><tpages>5</tpages></addata></record> |
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subjects | 24-h urine Adult diagnosis Female Humans Medical disorders Medical procedures Obstetrics Pre-eclampsia Pre-Eclampsia - diagnosis Pre-Eclampsia - urine Pregnancy Proteins proteinuria Proteinuria - urine Reagent Strips Reproducibility of Results Sensitivity and Specificity Time Factors Urinalysis Urine urine dipstick |
title | Accuracy of urine dipsticks, 2-h and 12-h urine collections for protein measurement as compared with the 24-h collection |
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